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Gene Ontology Browser
Term Detail
GO term:chemical synaptic transmission
Synonym: neurotransmission
Synonym: signal transmission across a synapse
Synonym: synaptic transmission
GO id:GO:0007268
Definition:The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acell communication
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (716 genes, 1304 annotations)
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (716 genes, 1304 annotations)
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (716 genes, 1304 annotations)
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (716 genes, 1304 annotations)
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (716 genes, 1304 annotations)
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +


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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory