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Gene Ontology Browser
Term Detail
GO term:chemical synaptic transmission
Synonym: neurotransmission
Synonym: signal transmission across a synapse
Synonym: synaptic transmission
GO id:GO:0007268
Definition:The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        is-acell-cell signaling
                                                is-asynaptic signaling
                                                        is-atrans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling
                                                                        is-aanterograde trans-synaptic signaling by nitric oxide
                                                                        is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                        is-achemical synaptic transmission [GO:0007268] (537 genes, 1053 annotations)
                                                                                part-ofcalcium ion-regulated exocytosis of neurotransmitter +
                                                                                part-ofchemical synaptic transmission, postsynaptic +
                                                                                is-aexcitatory chemical synaptic transmission
                                                                                part-ofinduction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
                                                                                is-ainhibitory chemical synaptic transmission
                                                                                regulatesmodification of synaptic structure, modulating synaptic transmission
                                                                                regulatesmodulation of synaptic transmission +
                                                                                negatively-regulatesnegative regulation of synaptic transmission +
                                                                                is-aneuromuscular synaptic transmission +
                                                                                is-aneuron-neuron synaptic transmission +
                                                                                part-ofneurotransmitter secretion +
                                                                                part-ofphenylethylamine biosynthetic process involved in synaptic transmission
                                                                                part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                                is-apositive regulation of synapse maturation by synaptic transmission
                                                                                positively-regulatespositive regulation of synaptic transmission +
                                                                                part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                                regulatesprotein catabolic process, modulating synaptic transmission
                                                                                regulatesregulation of modification of synapse structure, modulating synaptic transmission
                                                                                regulatesregulation of protein catabolic process at postsynapse, modulating synaptic transmission
                                                                                regulatesregulation of protein catabolic process at presynapse, modulating synaptic transmission
                                                                                regulatesregulation of protein catabolic process at synapse, modulating synaptic transmission +
                                                                                regulatesregulation of translation at postsynapse, modulating synaptic transmission
                                                                                regulatesregulation of translation at presynapse, modulating synaptic transmission
                                                                                regulatesregulation of translation at synapse, modulating synaptic transmission +
                                                                                regulatesretrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
                                                                                is-aspontaneous synaptic transmission +
                                                                                is-asynaptic transmission, cholinergic +
                                                                                regulatestrans-synaptic signaling by carbon monoxide, modulating synaptic transmission
                                                                                regulatestrans-synaptic signaling by endocannabinoid, modulating synaptic transmission
                                                                                regulatestrans-synaptic signaling by lipid, modulating synaptic transmission +
                                                                                regulatestrans-synaptic signaling by neuropeptide, modulating synaptic transmission
                                                                                regulatestrans-synaptic signaling by nitric oxide, modulating synaptic transmission +
                                                                                regulatestrans-synaptic signaling by soluble gas, modulating synaptic transmission +
                                                                                regulatestrans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
                                                                                regulatestrans-synaptic signalling, modulating synaptic transmission +


obsolete Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (537 genes, 1053 annotations)
                                                                        part-ofcalcium ion-regulated exocytosis of neurotransmitter +
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        part-ofinduction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodification of synaptic structure, modulating synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofneurotransmitter secretion +
                                                                        part-ofphenylethylamine biosynthetic process involved in synaptic transmission
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        regulatesprotein catabolic process, modulating synaptic transmission
                                                                        regulatesregulation of modification of synapse structure, modulating synaptic transmission
                                                                        regulatesregulation of protein catabolic process at postsynapse, modulating synaptic transmission
                                                                        regulatesregulation of protein catabolic process at presynapse, modulating synaptic transmission
                                                                        regulatesregulation of protein catabolic process at synapse, modulating synaptic transmission +
                                                                        regulatesregulation of translation at postsynapse, modulating synaptic transmission
                                                                        regulatesregulation of translation at presynapse, modulating synaptic transmission
                                                                        regulatesregulation of translation at synapse, modulating synaptic transmission +
                                                                        regulatesretrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +
                                                                        regulatestrans-synaptic signaling by carbon monoxide, modulating synaptic transmission
                                                                        regulatestrans-synaptic signaling by endocannabinoid, modulating synaptic transmission
                                                                        regulatestrans-synaptic signaling by lipid, modulating synaptic transmission +
                                                                        regulatestrans-synaptic signaling by neuropeptide, modulating synaptic transmission
                                                                        regulatestrans-synaptic signaling by nitric oxide, modulating synaptic transmission +
                                                                        regulatestrans-synaptic signaling by soluble gas, modulating synaptic transmission +
                                                                        regulatestrans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
                                                                        regulatestrans-synaptic signalling, modulating synaptic transmission +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                is-acell-cell signaling
                                        is-asynaptic signaling
                                                is-atrans-synaptic signaling
                                                        is-aanterograde trans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling by nitric oxide
                                                                is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                is-achemical synaptic transmission [GO:0007268] (537 genes, 1053 annotations)
                                                                        part-ofcalcium ion-regulated exocytosis of neurotransmitter +
                                                                        part-ofchemical synaptic transmission, postsynaptic +
                                                                        is-aexcitatory chemical synaptic transmission
                                                                        part-ofinduction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
                                                                        is-ainhibitory chemical synaptic transmission
                                                                        regulatesmodification of synaptic structure, modulating synaptic transmission
                                                                        regulatesmodulation of synaptic transmission +
                                                                        negatively-regulatesnegative regulation of synaptic transmission +
                                                                        is-aneuromuscular synaptic transmission +
                                                                        is-aneuron-neuron synaptic transmission +
                                                                        part-ofneurotransmitter secretion +
                                                                        part-ofphenylethylamine biosynthetic process involved in synaptic transmission
                                                                        part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                        is-apositive regulation of synapse maturation by synaptic transmission
                                                                        positively-regulatespositive regulation of synaptic transmission +
                                                                        part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                        regulatesprotein catabolic process, modulating synaptic transmission
                                                                        regulatesregulation of modification of synapse structure, modulating synaptic transmission
                                                                        regulatesregulation of protein catabolic process at postsynapse, modulating synaptic transmission
                                                                        regulatesregulation of protein catabolic process at presynapse, modulating synaptic transmission
                                                                        regulatesregulation of protein catabolic process at synapse, modulating synaptic transmission +
                                                                        regulatesregulation of translation at postsynapse, modulating synaptic transmission
                                                                        regulatesregulation of translation at presynapse, modulating synaptic transmission
                                                                        regulatesregulation of translation at synapse, modulating synaptic transmission +
                                                                        regulatesretrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
                                                                        is-aspontaneous synaptic transmission +
                                                                        is-asynaptic transmission, cholinergic +
                                                                        regulatestrans-synaptic signaling by carbon monoxide, modulating synaptic transmission
                                                                        regulatestrans-synaptic signaling by endocannabinoid, modulating synaptic transmission
                                                                        regulatestrans-synaptic signaling by lipid, modulating synaptic transmission +
                                                                        regulatestrans-synaptic signaling by neuropeptide, modulating synaptic transmission
                                                                        regulatestrans-synaptic signaling by nitric oxide, modulating synaptic transmission +
                                                                        regulatestrans-synaptic signaling by soluble gas, modulating synaptic transmission +
                                                                        regulatestrans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
                                                                        regulatestrans-synaptic signalling, modulating synaptic transmission +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        is-acell-cell signaling
                                                is-asynaptic signaling
                                                        is-atrans-synaptic signaling
                                                                is-aanterograde trans-synaptic signaling
                                                                        is-aanterograde trans-synaptic signaling by nitric oxide
                                                                        is-aanterograde trans-synaptic signaling by trans-synaptic protein complex
                                                                        is-achemical synaptic transmission [GO:0007268] (537 genes, 1053 annotations)
                                                                                part-ofcalcium ion-regulated exocytosis of neurotransmitter +
                                                                                part-ofchemical synaptic transmission, postsynaptic +
                                                                                is-aexcitatory chemical synaptic transmission
                                                                                part-ofinduction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
                                                                                is-ainhibitory chemical synaptic transmission
                                                                                regulatesmodification of synaptic structure, modulating synaptic transmission
                                                                                regulatesmodulation of synaptic transmission +
                                                                                negatively-regulatesnegative regulation of synaptic transmission +
                                                                                is-aneuromuscular synaptic transmission +
                                                                                is-aneuron-neuron synaptic transmission +
                                                                                part-ofneurotransmitter secretion +
                                                                                part-ofphenylethylamine biosynthetic process involved in synaptic transmission
                                                                                part-ofphenylethylamine metabolic process involved in synaptic transmission +
                                                                                is-apositive regulation of synapse maturation by synaptic transmission
                                                                                positively-regulatespositive regulation of synaptic transmission +
                                                                                part-ofpresynaptic process involved in chemical synaptic transmission +
                                                                                regulatesprotein catabolic process, modulating synaptic transmission
                                                                                regulatesregulation of modification of synapse structure, modulating synaptic transmission
                                                                                regulatesregulation of protein catabolic process at postsynapse, modulating synaptic transmission
                                                                                regulatesregulation of protein catabolic process at presynapse, modulating synaptic transmission
                                                                                regulatesregulation of protein catabolic process at synapse, modulating synaptic transmission +
                                                                                regulatesregulation of translation at postsynapse, modulating synaptic transmission
                                                                                regulatesregulation of translation at presynapse, modulating synaptic transmission
                                                                                regulatesregulation of translation at synapse, modulating synaptic transmission +
                                                                                regulatesretrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
                                                                                is-aspontaneous synaptic transmission +
                                                                                is-asynaptic transmission, cholinergic +
                                                                                regulatestrans-synaptic signaling by carbon monoxide, modulating synaptic transmission
                                                                                regulatestrans-synaptic signaling by endocannabinoid, modulating synaptic transmission
                                                                                regulatestrans-synaptic signaling by lipid, modulating synaptic transmission +
                                                                                regulatestrans-synaptic signaling by neuropeptide, modulating synaptic transmission
                                                                                regulatestrans-synaptic signaling by nitric oxide, modulating synaptic transmission +
                                                                                regulatestrans-synaptic signaling by soluble gas, modulating synaptic transmission +
                                                                                regulatestrans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
                                                                                regulatestrans-synaptic signalling, modulating synaptic transmission +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory