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Lrp6
Gene Detail
Symbol

Name
ID
Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218
Synonyms
Cd, Gw, ska26, skam26Jus, skax26
Feature Type
protein coding gene
Genetic Map
Chromosome 6
65.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:134446476-134566965 bp, - strand
From VEGA annotation of GRCm38

  120490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRP6
Protein SuperFamily: low density lipoprotein receptor-related protein, 5/6 types
Gene Tree: Lrp6

Human
homologs
LRP6, low density lipoprotein receptor-related protein 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4040
neXtProt AC: NX_O75581

Human Synonyms: ADCAD2

Human Chr (Location): 12p13.2; chr12:12116025-12267007 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LRP6

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Chemically induced (ENU)(3) Gene trapped(18) Spontaneous(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae.
 
Human Diseases Modeled in Mice Using Lrp6 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Lrp6 interacts with 402 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (168 annotations)
Process anterior/posterior pattern specification, axis elongation, ...
Component caveola, cell, ...
Function apolipoprotein binding, coreceptor activity involved in Wnt signaling pathway, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (268)    Tissues (160)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 190
Northern blot 3
Western blot 13
RT-PCR 56
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lrp6 ; ZFIN lrp6    NEW 
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(15) Primer pair(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021240 (Evidence)
Ensembl Gene Model ENSMUSG00000030201 (Evidence)
Entrez Gene 16974 (Evidence)
Consensus CDS Project CCDS39678.1
International Mouse Phenotyping Consortium Status Lrp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021240 VEGA Gene Model | MGI Sequence Detail 120490 C57BL/6J ±  kb
transcript OTTMUST00000050309 VEGA | MGI Sequence Detail 9368 Not Applicable 
polypeptide OTTMUSP00000023469 VEGA | MGI Sequence Detail 1613 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(1482 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 EGF-like domain
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR017049 Low density lipoprotein receptor-related protein, 5/6
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009927 low-density lipoprotein receptor-related protein 6
References
(Earliest) J:13045 Morgan WC, A new crooked tail mutation involving distinctive pleiotropism. J Genet. 1954;52:354-373
(Latest) J:221356 Snowball J, et al., Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015 May 15;401(2):264-75
All references(143)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1829, MGI:3043025, MGI:3577498, MGI:88317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory