Symbol
Name
ID

Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Heat intolerance
Disease(s) Associated with LRP6	Heat intolerance
tooth agenesis

Mouse Phenotypes

decreased susceptibility to diet-induced obesity

decreased susceptibility to induced hypothermia

increased circulating bilirubin level

decreased circulating glucose level

increased circulating LDL cholesterol level

increased circulating triglyceride level

increased circulating VLDL triglyceride level

hyperlipidemia

increased circulating aspartate transaminase level

improved glucose tolerance

increased insulin sensitivity

insulin resistance

increased circulating adiponectin level

abnormal lipid homeostasis

increased liver cholesterol level

increased cholesterol level

abnormal fatty acids level

decreased liver triglyceride level

increased liver triglyceride level

Availability

Mouse Genotype

Lrp6^tm1Arma/Lrp6^tm1Arma

Lrp6^{Gt(LST067)Byg}/Lrp6⁺

Lrp6^tm1Arma/Lrp6⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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