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Symbol
Name
ID 		Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
Sparse scalp hair
Aplasia of the maxilla
Short face
Eclabion
Abnormal dental morphology
Short dental root
Taurodontia
Peg-shaped maxillary lateral incisors
Abnormal primary molar morphology
Microdontia
Agenesis of central incisor
Agenesis of lateral incisor
Agenesis of maxillary lateral incisor
Agenesis of permanent teeth
Tooth agenesis
Anodontia
Hypodontia
Oligodontia
Oligodontia of primary teeth
Selective tooth agenesis
Agenesis of molar
Agenesis of permanent molar
Agenesis of first permanent molar tooth
Agenesis of premolar
Agenesis of mandibular premolar
Abnormality of canine
Delayed eruption of teeth
Delayed eruption of permanent teeth
Enamel hypoplasia
Hypoplasia of teeth
Abnormality of primary teeth
Dental malocclusion
Widely spaced teeth
Orofacial cleft
Impaired mastication
Sparse eyebrow
Short eyelashes
Disease(s) Associated with LRP6
tooth agenesis

Mouse Phenotypes
abnormal cranium morphology
small cranium
abnormal frontal bone morphology
thin neurocranium
small lower incisors
long upper incisors
short incisors
abnormal molar cusp morphology
decreased molar number
small molars
abnormal tooth development
abnormal tooth eruption
growth retardation of molars
cleft upper lip
cleft palate
protruding tongue
abnormal nose morphology
abnormal head shape
abnormal outer ear morphology
Availability Mouse Genotype
Lrp6Cd/Lrp6Cd
Lrp6tm1.2Cjz/Lrp6tm1.2Cjz
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory