125 phenotypes from 11 alleles in 22 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lrp6Cd/Lrp6+ A-Lrp6Cd	abnormal caudal vertebrae morphology	J:13045
	abnormal lumbar vertebrae morphology	J:13045
	abnormal sacral vertebrae morphology	J:13045
	abnormal vertebrae morphology	J:13045
	kinked tail	J:13045, J:58433
	small caudal vertebrae	J:13045
	vertebral fusion	J:13045
Lrp6Cd/Lrp6+ involves: A * 129/Sv	kinked tail	J:58433
Lrp6Cd/Lrp6+ involves: A * C57BL/6	kinked tail	J:58433
Lrp6Cd/Lrp6+ involves: A * DBA	kinked tail	J:58433
Lrp6Cd/Lrp6Cd A-Lrp6Cd	abnormal caudal vertebrae morphology	J:13045, J:101423
	abnormal coat appearance	J:13045
	abnormal cranium morphology	J:13045
	abnormal frontal bone morphology	J:13045
	abnormal head movements	J:13045
	abnormal head shape	J:13045
	abnormal lumbar vertebrae morphology	J:13045, J:101423
	abnormal molar cusp morphology	J:12999
	abnormal nose morphology	J:13045
	abnormal outer ear morphology	J:13045
	abnormal sacral vertebrae morphology	J:13045
	abnormal somite development	J:101423
	abnormal tail ring morphology	J:12999, J:13045
	abnormal tooth development	J:12998
	abnormal tooth eruption	J:12999, J:13045
	abnormal vertebrae morphology	J:13045
	anophthalmia	J:13045
	caudal vertebral fusion	J:13045, J:101423
	decreased birth body size	J:12998
	decreased body size	J:13045, J:58433
	decreased molar number	J:12998, J:12999
	decreased somite size	J:101423
	delayed bone ossification	J:13045
	delayed cranial suture closure	J:13045
	embryonic lethality before implantation, incomplete penetrance	J:13045, J:58433
	exencephaly	J:13045, J:58433, J:101423
	growth retardation of molars	J:12998
	hemivertebra	J:101423
	kinked tail	J:13045
	long upper incisors	J:13045
	microphthalmia	J:12999, J:13045
	neonatal lethality, incomplete penetrance	J:13045, J:58433
	postnatal growth retardation	J:13045
	prenatal lethality, incomplete penetrance	J:13045
	short incisors	J:12998
	small caudal vertebrae	J:13045
	small cranium	J:13045
	small lower incisors	J:12999
	small molars	J:12998, J:12999
	sparse hair	J:12999, J:13045
	thin neurocranium	J:13045
Lrp6Cd/Lrp6Gt(Ex187)Byg involves: 129P2/OlaHsd * A	abnormal vertebrae development	J:101423
	exencephaly	J:101423
	kinked tail	J:101423
	prenatal lethality	J:101423
	vertebral fusion	J:101423
Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	decreased bone mineral density	J:111359
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129P2/OlaHsd	abnormal external female genitalia morphology	J:155250
	abnormal external male genitalia morphology	J:155250
	incomplete somite formation	J:93008
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal cerebellum morphology	J:64989
	abnormal digit morphology	J:64989
	abnormal midbrain morphology	J:64989
	abnormal midbrain-hindbrain boundary morphology	J:64989
	abnormal tail bud morphology	J:64989
	absent apical ectodermal ridge	J:64989
	absent inferior colliculus	J:64989
	absent paraxial mesoderm	J:64989
	absent vertebrae	J:64989
	exencephaly	J:64989
	forelimb oligodactyly	J:64989
	incomplete somite formation	J:64989
	perinatal lethality, complete penetrance	J:64989
	sirenomelia	J:64989
	small tail bud	J:64989
	spina bifida	J:64989
Lrp6Gt(LST067)Byg/Lrp6+ B6.Cg-Lrp6Gt(LST067)Byg	abnormal brown adipose tissue morphology	J:182772
	abnormal liver morphology	J:182772
	abnormal liver physiology	J:182772
	decreased body weight	J:182772
	decreased circulating glucose level	J:182772
	decreased liver triglyceride level	J:182772
	decreased susceptibility to diet-induced obesity	J:182772
	decreased susceptibility to induced hypothermia	J:182772
	improved glucose tolerance	J:182772
	increased brown fat cell number	J:182772
	increased circulating adiponectin level	J:182772
	increased insulin sensitivity	J:182772
Lrp6Gt(LST067)Byg/Lrp6+ involves: 129P2/OlaHsd	abnormal lipid homeostasis	J:155275
Lrp6Gw/Lrp6+ involves: 101/H * BALB/c * C3H/HeH	abnormal forebrain morphology	J:170646
	abnormal head morphology	J:170646
	kinked tail	J:170646
Lrp6Gw/Lrp6+ involves: 101/H * BALB/cOlaHsd * C3H/HeH	kinked tail	J:93195
Lrp6Gw/Lrp6Gw involves: 101/H * BALB/c * C3H/HeH	abnormal head morphology	J:170646
	abnormal telencephalon morphology	J:170646
	forebrain hypoplasia	J:170646
	kinked tail	J:170646
Lrp6Gw/Lrp6Gw involves: 101/H * BALB/cOlaHsd * C3H/HeH	abnormal forebrain development	J:93195
	decreased embryo size	J:93195
	exencephaly	J:93195
Lrp6m10Bei/Lrp6m10Bei involves: A/J * C57BL/6	abnormal neural tube closure	J:199782
	craniorachischisis	J:199782
	exencephaly	J:199782
	spina bifida	J:199782
Lrp6rs/Lrp6Gt(Ex187)Byg involves: 129P2/OlaHsd * BALB/c	incomplete somite formation	J:93008
Lrp6rs/Lrp6rs involves: BALB/c	abnormal dorsal-ventral polarity of the somites	J:93008
	abnormal paraxial mesoderm morphology	J:93008
	abnormal vertebrae morphology	J:93008
	abnormal vertebral arch morphology	J:93008
	curly tail	J:93008
	delayed bone ossification	J:93008
	fused dorsal root ganglion	J:93008
	incomplete somite formation	J:93008
	oligodactyly	J:93008
	osteoporosis	J:93008
	postnatal lethality, incomplete penetrance	J:93008
	rib fusion	J:93008
	short tail	J:93008
	spina bifida cystica	J:93008
	spina bifida occulta	J:93008
Lrp6rs/Lrp6rs involves: BALB/c * C57BL/6	curly tail	J:93008
	short tail	J:93008
Lrp6skax26/Lrp6+ involves: 129S6/SvEvTac * C57BL/6J	curly tail	J:206979
	kinked tail	J:206979
Lrp6skax26/Lrp6skax26 involves: 129S6/SvEvTac * C57BL/6J	abnormal orientation of outer hair cell stereociliary bundles	J:206979
	curly tail	J:206979
	kinked tail	J:206979
Lrp6skax26/Lrp6skax26 involves: C57BL/6J	curly tail	J:89098
	kinked tail	J:89098
Lrp6tm1.1Vari/Lrp6tm1.1Vari involves: 129S1/Sv	no abnormal phenotype detected	J:178499
Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	delayed bone ossification	J:178499
	normal skeleton phenotype	J:178499
Lrp6tm1.1Vari/Lrp6tm1.2Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	delayed bone ossification	J:178499
	normal skeleton phenotype	J:178499
Lrp6tm1.2Cjz/Lrp6Gt(Ex187)Byg involves: 129P2/OlaHsd * C57BL/6J * CD-1 * SJL	abnormal external female genitalia morphology	J:155250
	abnormal external male genitalia morphology	J:155250
	abnormal eye development	J:155250
	abnormal limb morphology	J:155250
	exencephaly	J:155250
	failure of eyelid fusion	J:155250
	microphthalmia	J:155250
	retina coloboma	J:155250
	short tail	J:155250
	spina bifida	J:155250
Lrp6tm1.2Cjz/Lrp6tm1.2Cjz involves: C57BL/6J * CD-1 * SJL	abnormal digit morphology	J:155250
	abnormal external female genitalia morphology	J:155250
	abnormal external male genitalia morphology	J:155250
	abnormal eye development	J:155250
	abnormal forelimb morphology	J:155250
	abnormal hindlimb morphology	J:155250
	abnormal limb morphology	J:155250
	cleft palate	J:155250
	cleft upper lip	J:155250
	exencephaly	J:155250
	failure of eyelid fusion	J:155250
	forelimb oligodactyly	J:155250
	microphthalmia	J:155250
	polydactyly	J:155250
	protruding tongue	J:155250
	retina coloboma	J:155250
	short limbs	J:155250
	short tail	J:155250
	sirenomelia	J:155250
	spina bifida	J:155250
Lrp6tm1.2Vari/Lrp6tm1.2Vari involves: 129S1/Sv	neonatal lethality, complete penetrance	J:178499
Lrp6tm1Arma/Lrp6+ C57BL/6-Lrp6tm1Arma	increased cholesterol level	J:210538
	increased circulating LDL cholesterol level	J:210538
	increased circulating triglyceride level	J:210538
Lrp6tm1Arma/Lrp6tm1Arma C57BL/6-Lrp6tm1Arma	abnormal fatty acids level	J:210538
	abnormal lipid homeostasis	J:210538
	abnormal liver morphology	J:225450
	enlarged liver	J:210538
	hepatic steatosis	J:210538, J:225450
	hyperlipidemia	J:210538
	increased cholesterol level	J:210538
	increased circulating aspartate transaminase level	J:210538
	increased circulating bilirubin level	J:210538
	increased circulating LDL cholesterol level	J:210538
	increased circulating triglyceride level	J:210538
	increased circulating VLDL triglyceride level	J:210538
	increased liver cholesterol level	J:210538, J:225450
	increased liver triglyceride level	J:210538
	insulin resistance	J:210538
	liver fibrosis	J:225450
	liver inflammation	J:225450