64 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ahi1tm1Jgg/Ahi1+ Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal renal tubule morphology	J:154321
	dilated renal tubule	J:154321
	increased circulating creatinine level	J:154321
	kidney cyst	J:154321
	small kidney	J:154321
Ctnnb1Bfc/Ctnnb1+ Dkk1tm1Lmgd/Dkk1+ Lrp6Gw/Lrp6+ either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)	abnormal head size	J:170646
	caudal body truncation	J:170646
Ctnnb1Bfc/Ctnnb1+ Lrp6Gw/Lrp6+ either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)	abnormal head size	J:170646
Dkk1tm1Lmgd/Dkk1+ Lrp6Gw/Lrp6+ involves: 101/H * 129 * BALB/c * C3H	abnormal head morphology	J:170646
	kinked tail	J:170646
Dkk1tm1Lmgd/Dkk1+ Lrp6Gw/Lrp6Gw involves: 101/H * 129 * BALB/c * C3H	abnormal head morphology	J:170646
Lrp5tm1.1Vari/Lrp5tm1.1Vari Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:178499
	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal cranium morphology	J:178499
	abnormal epiphyseal plate morphology	J:178499
	abnormal limb morphology	J:178499
	abnormal skeleton morphology	J:178499
	abnormal trabecular bone morphology	J:178499
	decreased body size	J:178499
	ectopic cartilage	J:178499
	neonatal lethality, complete penetrance	J:178499
	split sternum	J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:178499
	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal cranium morphology	J:178499
	abnormal epiphyseal plate morphology	J:178499
	abnormal joint morphology	J:178499
	abnormal limb morphology	J:178499
	abnormal osteoblast differentiation	J:178499
	abnormal skeleton morphology	J:178499
	abnormal trabecular bone morphology	J:178499
	decreased body size	J:178499
	decreased width of hypertrophic chondrocyte zone	J:178499
	ectopic cartilage	J:178499
	failure of bone ossification	J:178499
	neonatal lethality, complete penetrance	J:178499
	split sternum	J:178499
Lrp5tm1Jfh/Lrp5+ Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129S5/SvEvBrd * C57BL/6	abnormal bone ossification	J:91055
	forelimb oligodactyly	J:91055
Lrp5tm1Jfh/Lrp5+ Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129S5/SvEvBrd * C57BL/6	abnormal amnion morphology	J:91055
	abnormal developmental patterning	J:91055
	abnormal extraembryonic tissue morphology	J:91055
	abnormal primitive streak formation	J:91055
	absent somites	J:91055
	increased forebrain size	J:91055
	lethality throughout fetal growth and development, complete penetrance	J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129S5/SvEvBrd * C57BL/6	absent carpal bone	J:91055
	absent fibula	J:91055
	absent metacarpal bones	J:91055
	decreased body size	J:91055
	decreased fetal size	J:91055
	oligodactyly	J:91055
	postnatal lethality, incomplete penetrance	J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129S5/SvEvBrd * C57BL/6	abnormal developmental patterning	J:91055
	abnormal germ layer development	J:91055
	abnormal mesoderm development	J:91055
	absent allantois	J:91055
	absent amnion	J:91055
	absent endoderm	J:91055
	lethality throughout fetal growth and development, complete penetrance	J:91055
Lrp5tm1Lex/Lrp5+ Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal forelimb morphology	J:111359
	abnormal limb morphology	J:111359
	decreased bone mass	J:111359
	decreased bone mineral density	J:111359
	forelimb oligodactyly	J:111359
	synostosis	J:111359
Lrp5tm1Lex/Lrp5tm1Lex Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal carpal bone morphology	J:111359
	abnormal cranium morphology	J:111359
	abnormal forelimb morphology	J:111359
	abnormal hindlimb morphology	J:111359
	abnormal limb morphology	J:111359
	abnormal tarsal bone morphology	J:111359
	decreased bone mass	J:111359
	decreased bone mineral density	J:111359
	forelimb oligodactyly	J:111359
	monodactyly	J:111359
	synostosis	J:111359
Lrp5tm1Lex/Lrp5tm1Lex Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	decreased bone mineral density	J:111359
Lrp6Gt(Ex187)Byg/Lrp6+ Wnt3avt/Wnt3a+ involves: 129P2/OlaHsd * C57BL/6 * C57BR	kinked tail	J:64989
Lrp6Gt(Ex187)Byg/Lrp6+ Wnt3avt/Wnt3avt involves: 129P2/OlaHsd * C57BL/6 * C57BR	vestigial tail	J:64989
Lrp6Gt(Ex187)Byg/Lrp6+ Rspo2tm1Nuv/Rspo2tm1Nuv involves: 129 * 129P2/OlaHsd * C57BL/6	abnormal craniofacial morphology	J:171482
	cleft palate	J:171482
	cleft upper lip	J:171482
	decreased cranium height	J:171482
	short mandible	J:171482
	short maxilla	J:171482
	short Meckel's cartilage	J:171482
Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg Rspo2tm1Nuv/Rspo2tm1Nuv involves: 129 * 129P2/OlaHsd * C57BL/6	prenatal lethality, complete penetrance	J:171482
Lrp6Gw/Lrp6+ Wnt3tm1Brd/Wnt3+ involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H	kinked tail	J:170646
Lrp6skax26/Lrp6+ Vangl2Lp/Vangl2+ involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J	abnormal orientation of outer hair cell stereociliary bundles	J:206979
	curly tail	J:206979
	kinked tail	J:206979
	spina bifida	J:206979