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Gene Ontology Browser
Term Detail
GO term:bone remodeling
Synonym: bone remodelling
GO id:GO:0046849
Definition:The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-atissue remodeling
                                        is-aatrial ventricular junction remodeling +
                                        is-ablood vessel remodeling +
                                        is-abone remodeling [GO:0046849] (77 genes, 91 annotations)
                                                part-ofbone resorption +
                                                negatively-regulatesnegative regulation of bone remodeling +
                                                part-ofossification involved in bone remodeling
                                                positively-regulatespositive regulation of bone remodeling +
                                                regulatesregulation of bone remodeling +
                                        is-aclearance of damaged tissue involved in inflammatory response wound healing
                                        is-aconnective tissue replacement involved in inflammatory response wound healing
                                        is-aerythrocyte clearance +
                                        is-amammary gland involution +
                                        negatively-regulatesnegative regulation of tissue remodeling +
                                        is-aneutrophil clearance
                                        positively-regulatespositive regulation of tissue remodeling +
                                        regulatesregulation of tissue remodeling +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-atissue remodeling
                                        is-aatrial ventricular junction remodeling +
                                        is-ablood vessel remodeling +
                                        is-abone remodeling [GO:0046849] (77 genes, 91 annotations)
                                                part-ofbone resorption +
                                                negatively-regulatesnegative regulation of bone remodeling +
                                                part-ofossification involved in bone remodeling
                                                positively-regulatespositive regulation of bone remodeling +
                                                regulatesregulation of bone remodeling +
                                        is-aclearance of damaged tissue involved in inflammatory response wound healing
                                        is-aconnective tissue replacement involved in inflammatory response wound healing
                                        is-aerythrocyte clearance +
                                        is-amammary gland involution +
                                        negatively-regulatesnegative regulation of tissue remodeling +
                                        is-aneutrophil clearance
                                        positively-regulatespositive regulation of tissue remodeling +
                                        regulatesregulation of tissue remodeling +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory