| GO term: | bone remodeling |
| Synonym: | bone remodelling |
| GO id: | GO:0046849 |
| Definition: | The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processmulticellular organismal processsingle-multicellular organism processtissue remodelingatrial ventricular junction remodeling +blood vessel remodeling +bone remodeling [GO:0046849] (66 genes, 79 annotations)bone resorption +negative regulation of bone remodeling +ossification involved in bone remodelingpositive regulation of bone remodeling +regulation of bone remodeling +clearance of damaged tissue involved in inflammatory response wound healingconnective tissue replacement involved in inflammatory response wound healingerythrocyte clearance +mammary gland involution +negative regulation of tissue remodeling +neutrophil clearancepositive regulation of tissue remodeling +regulation of tissue remodeling +biological_processsingle-organism processsingle-multicellular organism processtissue remodelingatrial ventricular junction remodeling +blood vessel remodeling +bone remodeling [GO:0046849] (66 genes, 79 annotations)bone resorption +negative regulation of bone remodeling +ossification involved in bone remodelingpositive regulation of bone remodeling +regulation of bone remodeling +clearance of damaged tissue involved in inflammatory response wound healingconnective tissue replacement involved in inflammatory response wound healingerythrocyte clearance +mammary gland involution +negative regulation of tissue remodeling +neutrophil clearancepositive regulation of tissue remodeling +regulation of tissue remodeling +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
||
|
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. |
last database update 05/08/2013 MGI 5.13 |
|
|
|
||
Analysis Tools