Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LGMN
  • Mouse genes Lgmn
  • Rat genes Lgmn
  • Zfish genes lgmn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgmn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	LGMN	IDA		Human	PMID:18374643
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	LGMN	IDA		Human	PMID:22718532
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	LGMN	IDA		Human	PMID:25326800
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	LGMN	IMP		Human	PMID:9065484
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	LGMN	IDA		Human	PMID:9821970
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Lgmn	IMP		Mouse	MGI:MGI:5702834|PMID:25326800
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Lgmn	IDA		Mouse	MGI:MGI:6148544|PMID:22718532
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Lgmn	IDA		Mouse	MGI:MGI:1303164|PMID:9742219
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Lgmn	IMP		Rat	PMID:18374643|RGD:13514088
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Lgmn	IMP		Rat	PMID:9065484|RGD:13514076
Molecular Function	GO:0008233	peptidase activity	LGMN	IDA		Human	PMID:136644
Molecular Function	GO:0008233	peptidase activity	Lgmn	IMP	MGI:MGI:2676125	Mouse	PMID:12775715
Cellular Component	GO:0045177	apical part of cell	Lgmn	IDA		Mouse	PMID:12775715
Cellular Component	GO:0005737	cytoplasm	LGMN	IDA		Human	PMID:18377911
Cellular Component	GO:0070062	extracellular exosome	LGMN	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	LGMN	IDA		Human	PMID:18377911
Cellular Component	GO:0005770	late endosome	Lgmn	IDA		Mouse	PMID:12775715
Cellular Component	GO:0005764	lysosome	Lgmn	IDA		Mouse	MGI:MGI:1303164|PMID:9742219
Cellular Component	GO:0005764	lysosome	Lgmn	IDA		Rat	PMID:9742219|RGD:704328
Cellular Component	GO:0048471	perinuclear region of cytoplasm	LGMN	IDA		Human	PMID:21237226
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	LGMN	IDA		Human	PMID:18374643
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	LGMN	IDA		Human	PMID:9821970
Biological Process	GO:0008306	associative learning	Lgmn	IGI	UniProtKB:P10636	Mouse	MGI:MGI:5702834|PMID:25326800
Biological Process	GO:0031103	axon regeneration	lgmn	IMP	ZFIN:ZDB-MRPHLNO-140912-4	Zfish	PMID:24747977
Biological Process	GO:0031103	axon regeneration	lgmn	IMP	ZFIN:ZDB-MRPHLNO-140912-3	Zfish	PMID:24747977
Biological Process	GO:1904646	cellular response to amyloid-beta	LGMN	IDA		Human	PMID:25326800
Biological Process	GO:0071277	cellular response to calcium ion	LGMN	IDA		Human	PMID:21237226
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	LGMN	IDA		Human	PMID:21237226
Biological Process	GO:0097061	dendritic spine organization	Lgmn	IGI	UniProtKB:P10636	Mouse	MGI:MGI:5702834|PMID:25326800
Biological Process	GO:0007613	memory	Lgmn	IGI	UniProtKB:P10636	Mouse	MGI:MGI:5702834|PMID:25326800
Biological Process	GO:0030502	negative regulation of bone mineralization	lgmn	IMP	ZFIN:ZDB-TALEN-181023-1	Zfish	PMID:28162997
Biological Process	GO:1901185	negative regulation of ERBB signaling pathway	Lgmn	IMP		Mouse	MGI:MGI:5008720|PMID:21292981
Biological Process	GO:0010629	negative regulation of gene expression	LGMN	IMP		Human	PMID:21237226
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Lgmn	IMP	MGI:MGI:2676125	Mouse	PMID:12775715
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	LGMN	IGI	UniProtKB:Q01105	Human	PMID:18374643
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	LGMN	IGI	UniProtKB:Q99490	Human	PMID:18374643
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	lgmn	IMP	ZFIN:ZDB-TALEN-181023-1	Zfish	PMID:28162997
Biological Process	GO:0008284	positive regulation of cell population proliferation	LGMN	IMP		Human	PMID:21237226
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	LGMN	IDA		Human	PMID:18377911
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Lgmn	IGI	UniProtKB:P10636	Mouse	MGI:MGI:5702834|PMID:25326800
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	LGMN	IMP		Human	PMID:21237226
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	LGMN	IDA		Human	PMID:18377911
Biological Process	GO:0006508	proteolysis	Lgmn	IDA		Mouse	MGI:MGI:1303164|PMID:9742219
Biological Process	GO:0006508	proteolysis	Lgmn	IDA		Mouse	PMID:12775715
Biological Process	GO:0006508	proteolysis	Lgmn	IMP	MGI:MGI:2676125	Mouse	PMID:18374643
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Lgmn	IMP		Mouse	MGI:MGI:3710046|PMID:17350006
Biological Process	GO:0032801	receptor catabolic process	Lgmn	IMP		Mouse	MGI:MGI:5008720|PMID:21292981
Biological Process	GO:0003014	renal system process	Lgmn	IMP		Mouse	MGI:MGI:5008720|PMID:21292981
Biological Process	GO:0010447	response to acidic pH	LGMN	IDA		Human	PMID:18374643
Biological Process	GO:0010447	response to acidic pH	Lgmn	IMP		Mouse	MGI:MGI:5702834|PMID:25326800
Biological Process	GO:0010447	response to acidic pH	Lgmn	IMP	MGI:MGI:2676125	Mouse	PMID:18374643
Biological Process	GO:0097264	self proteolysis	LGMN	IDA		Human	PMID:18374643
Biological Process	GO:0097264	self proteolysis	LGMN	IDA		Human	PMID:9821970
Biological Process	GO:0042246	tissue regeneration	lgmn	IMP	ZFIN:ZDB-MRPHLNO-140912-4	Zfish	PMID:24747977
Biological Process	GO:0042246	tissue regeneration	lgmn	IMP	ZFIN:ZDB-MRPHLNO-140912-3	Zfish	PMID:24747977

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern