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Lgmn
Gene Detail
Symbol

Name
ID
Lgmn
legumain
MGI:1330838
Synonyms
AEP, preprolegumain, Prsc1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
51.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:102394084-102439813 bp, - strand
From VEGA annotation of GRCm38

  45730 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transamidase/peptidase, legumain type
Gene Tree: Lgmn

Human
homologs
Human Homolog LGMN, legumain
NCBI Gene ID 5641
neXtProt AC  NX_Q99538
Human Synonyms  AEP, LGMN1, PRSC1
Human Chr (Location)  14q32.1; chr14:92703807-92748702 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele exhibit slow postnatal weight gain, develop features of hemophagocytic syndrome, and accumulate giant lysosomes in renal tubule cells. Homozygotes for another null allele display impaired TLR9 signaling in dendritic cells, progressive kidney pathology, and proteinuria.
 
Phenotype Images(5)
Interactions
Lgmn interacts with 82 markers (Mir7-1, Mir30a, Mir30d, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (91)    Tissues (10)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 91
cDNA source data(165)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(165) cDNA(165)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023302 (Evidence)
Ensembl Gene ModelENSMUSG00000021190 (Evidence)
Entrez Gene19141 (Evidence)
UniGene17185
DFCITC1575279
DoTSDT.535151
EC3.4.22.34
PDB4NOL, 4NOM, 4NOK, 4NOJ
Consensus CDS ProjectCCDS26119.1
International Mouse Knockout Project StatusLgmn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023302 VEGA Gene Model | MGI Sequence Detail 45730 C57BL/6J ±  kb
transcript OTTMUST00000056434 VEGA | MGI Sequence Detail 1835 Not Applicable 
polypeptide OTTMUSP00000027122 VEGA | MGI Sequence Detail 435 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(380 from dbSNP Build 137)    SNPs within 2kb including multiple locations(382)
Protein-related
information
ResourceIDDescription
InterPro IPR001096 Peptidase C13, legumain
Protein Ontology PR:000009780 legumain
References
(Earliest) J:50324 Chen JM, et al., Cloning and expression of mouse legumain, a lysosomal endopeptidase. Biochem J. 1998 Oct 1;335(Pt 1):111-7
(Latest) J:193856 Yamane T, et al., Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney. Biochem Biophys Res Commun. 2013 Jan 11;430(2):482-7
All references(44)
Other
accession IDs
MGI:2144882, MGI:2144957

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory