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Lgmn Gene Detail
Summary
  • Symbol
    Lgmn
  • Name
    legumain
  • Synonyms
    AEP, preprolegumain, Prsc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330838
    NCBI Gene: 19141
  • Gene Overview
    MyGene.info: LGMN
Location & Maps
more
  • Sequence Map
    Chr12:102394084-102439813 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45730 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.45 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LGMN, legumain
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LGMN, legumain
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AEP, LGMN1, PRSC1
  • Links
    NCBI Gene ID: 5641
    neXtProt AC: NX_Q99538

  • Chr Location
    14q32.1; chr14:92703807-92748702 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 2 alleles in 3 genetic backgrounds
    5 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Targeted
    4
  • Genomic Mutations
    1 involving Lgmn
  • Incidental Mutations
Homozygotes for a null allele exhibit slow postnatal weight gain, develop features of hemophagocytic syndrome, and accumulate giant lysosomes in renal tubule cells. Homozygotes for another null allele display impaired TLR9 signaling in dendritic cells, progressive kidney pathology, and proteinuria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023302 VEGA Gene Model | MGI Sequence Detail 45730 C57BL/6J ±  kb
transcript OTTMUST00000056434 VEGA | MGI Sequence Detail 1835 Not Applicable  
polypeptide OTTMUSP00000027122 VEGA | MGI Sequence Detail 435 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    376 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 165
    cDNA 165

    Microarray probesets 3
Other
Accession IDs
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MGI:2144882, MGI:2144957
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:50324 Chen JM, et al., Cloning and expression of mouse legumain, a lysosomal endopeptidase. Biochem J. 1998 Oct 1;335(Pt 1):111-7
  • Latest
    J:228032 Zhang Z, et al., Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory