Lgmn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgmn
legumain
MGI:1330838

46 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lgmn^{tm1b(NCOM)Mfgc}/Lgmn^{tm1b(NCOM)Mfgc} C57BL/6N-Lgmn^{tm1b(NCOM)Mfgc}/Tcp	decreased body length	J:211773
	decreased prepulse inhibition	J:211773
	short tibia	J:211773
Lgmn^tm1Cptr/Lgmn^tm1Cptr B6.129S6-Lgmn^tm1Cptr	abnormal adaptive immunity	J:155339
	abnormal kidney interstitium morphology	J:172774
	abnormal kidney outer medulla outer stripe morphology	J:172774
	abnormal kidney physiology	J:172774
	abnormal proximal convoluted tubule morphology	J:172774
	abnormal renal glomerulus morphology	J:172774
	albuminuria	J:172774
	decreased interleukin-6 secretion	J:155339
	decreased interleukin-12b secretion	J:155339
	decreased renal glomerular filtration rate	J:172774
	decreased tumor necrosis factor secretion	J:155339
	enlarged spleen	J:172774
	hydronephrosis	J:172774
	increased circulating creatinine level	J:172774
	increased urine protein level	J:172774
	kidney cortex atrophy	J:172774
	lysosomal protein accumulation	J:172774
	pale kidney	J:172774
	renal glomerulus cyst	J:172774
	renal interstitial fibrosis	J:172774
	renal tubule atrophy	J:172774
	slow postnatal weight gain	J:172774
Lgmn^tm1Ihn/Lgmn^tm1Ihn involves: 129P2/OlaHsd * C57BL/6	abnormal bone marrow cell morphology/development	J:143886
	abnormal erythrocyte morphology	J:143886
	abnormal macrophage physiology	J:143886
	abnormal NK cell physiology	J:143886
	abnormal spleen morphology	J:143886
	anemia	J:143886
	decreased erythrocyte cell number	J:143886
	decreased hematocrit	J:143886
	decreased hemoglobin content	J:143886
	decreased mean corpuscular hemoglobin	J:143886
	decreased mean corpuscular hemoglobin concentration	J:143886
	extramedullary hematopoiesis	J:143886
	normal immune system phenotype	J:143886
	increased body temperature	J:143886
	increased circulating tumor necrosis factor level	J:143886
	increased liver weight	J:143886
	increased lymphocyte cell number	J:143886
	increased spleen weight	J:143886
	reticulocytosis	J:143886
Lgmn^tm1Ihn/Lgmn^tm1Ihn involves: 129P2/OlaHsd * C57BL/6J	accumulation of giant lysosomes in kidney/renal tubule cells	J:85207
	decreased body weight	J:85207
	slow postnatal weight gain	J:85207

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23