Lgmntm1Ihn
Targeted Allele Detail
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Symbol: |
Lgmntm1Ihn |
Name: |
legumain; targeted mutation 1, Ikuko Hara-Nishimura |
MGI ID: |
MGI:2676125 |
Synonyms: |
AEP- |
Gene: |
Lgmn Location: Chr12:102360341-102405987 bp, - strand Genetic Position: Chr12, 51.45 cM
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Alliance: |
Lgmntm1Ihn page
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Enlargement of lysosomes in the kidney-proximal tubule cells of Lgmntm1Ihn/Lgmntm1Ihn mice
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:85207
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: 3 exons were flanked by loxP sites and excised prior to germline transmission via cre-mediated recombination. An frt-flanked neo cassette was left in an intron. Neither transcript nor protein was detected in homozygous mutant mice by RT-PCR and Western blot analyses of kidney tissue.
(J:85207)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lgmn Mutation: |
33 strains or lines available
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Original: |
J:85207 Shirahama-Noda K, et al., Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9 |
All: |
14 reference(s) |
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