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Lgmntm1Ihn
Targeted Allele Detail
Summary
Symbol: Lgmntm1Ihn
Name: legumain; targeted mutation 1, Ikuko Hara-Nishimura
MGI ID: MGI:2676125
Synonyms: AEP-
Gene: Lgmn  Location: Chr12:102360341-102405987 bp, - strand  Genetic Position: Chr12, 51.45 cM
Alliance: Lgmntm1Ihn page
Enlargement of lysosomes in the kidney-proximal tubule cells of Lgmntm1Ihn/Lgmntm1Ihn mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85207
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details3 exons were flanked by loxP sites and excised prior to germline transmission via cre-mediated recombination. An frt-flanked neo cassette was left in an intron. Neither transcript nor protein was detected in homozygous mutant mice by RT-PCR and Western blot analyses of kidney tissue. (J:85207)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgmn Mutation:  33 strains or lines available
References
Original:  J:85207 Shirahama-Noda K, et al., Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory