Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Htr2b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes HTR2B
- Mouse genes Htr2b
- Rat genes Htr2b
- Zfish genes htr2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2B	IDA		Human	PMID:12970106
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2B	IMP		Human	PMID:15625277
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2B	IDA		Human	PMID:15862800
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2B	IDA		Human	PMID:7582481
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR2B	IDA		Human	PMID:7926008
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Molecular Function	GO:0001965	G-protein alpha-subunit binding	HTR2B	IMP		Human	PMID:15625277
Molecular Function	GO:0001587	Gq/11-coupled serotonin receptor activity	HTR2B	IDA		Human	PMID:18703043
Molecular Function	GO:0005096	GTPase activator activity	Htr2b	IMP		Mouse	MGI:MGI:86840\|PMID:8621713
Molecular Function	GO:0005515	protein binding	HTR2B	IPI	UniProtKB:P28223	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	HTR2B	IPI	UniProtKB:P28335	Human	PMID:28258217
Molecular Function	GO:0005515	protein binding	Htr2b	IPI	UniProtKB:P25095	Rat	PMID:19023134\|RGD:8554388
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:12970106
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:15625277
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:15831837
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:15862800
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:17609583
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:18703043
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:19057895
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:19307114
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:7582481
Molecular Function	GO:0051378	serotonin binding	HTR2B	IDA		Human	PMID:7926008
Molecular Function	GO:0051378	serotonin binding	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Molecular Function	GO:0051378	serotonin binding	Htr2b	IDA		Rat	PMID:1505525\|RGD:61633
Cellular Component	GO:0005737	cytoplasm	HTR2B	IDA		Human	PMID:15925089
Cellular Component	GO:0005737	cytoplasm	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Cellular Component	GO:0005737	cytoplasm	Htr2b	IDA		Rat	PMID:10733010\|RGD:9743851
Cellular Component	GO:0030425	dendrite	Htr2b	IDA		Rat	PMID:9015317\|RGD:9743849
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2B	IDA		Human	PMID:12970106
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2B	IMP		Human	PMID:15625277
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2B	IDA		Human	PMID:15862800
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2B	IDA		Human	PMID:18703043
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	HTR2B	IDA		Human	PMID:7926008
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Cellular Component	GO:0016020	membrane	Htr2b	IDA		Rat	PMID:1505525\|RGD:61633
Cellular Component	GO:0043025	neuronal cell body	Htr2b	IDA		Rat	PMID:9015317\|RGD:9743849
Cellular Component	GO:0005654	nucleoplasm	HTR2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	HTR2B	IDA		Human	PMID:12970106
Cellular Component	GO:0005886	plasma membrane	HTR2B	IDA		Human	PMID:15625277
Cellular Component	GO:0005886	plasma membrane	HTR2B	IDA		Human	PMID:15862800
Cellular Component	GO:0005886	plasma membrane	HTR2B	IDA		Human	PMID:18703043
Cellular Component	GO:0005886	plasma membrane	HTR2B	IDA		Human	PMID:19023134
Cellular Component	GO:0005886	plasma membrane	HTR2B	IDA		Human	PMID:7926008
Cellular Component	GO:0005886	plasma membrane	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Cellular Component	GO:0005886	plasma membrane	Htr2b	IDA		Rat	PMID:19023134\|RGD:8554388
Cellular Component	GO:0005886	plasma membrane	Htr2b	IDA		Rat	PMID:9015317\|RGD:9743849
Biological Process	GO:0007202	activation of phospholipase C activity	HTR2B	IDA		Human	PMID:16517693
Biological Process	GO:0007202	activation of phospholipase C activity	HTR2B	IDA		Human	PMID:19057895
Biological Process	GO:0019722	calcium-mediated signaling	HTR2B	IMP		Human	PMID:8882600
Biological Process	GO:0003300	cardiac muscle hypertrophy	Htr2b	IMP		Mouse	MGI:MGI:4420536\|PMID:19023134
Biological Process	GO:0071418	cellular response to amine stimulus	Htr2b	IDA		Rat	PMID:1505525\|RGD:61633
Biological Process	GO:1904015	cellular response to serotonin	Htr2b	IDA		Rat	PMID:1505525\|RGD:61633
Biological Process	GO:0071502	cellular response to temperature stimulus	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Biological Process	GO:0019934	cGMP-mediated signaling	HTR2B	IDA		Human	PMID:12970106
Biological Process	GO:0048598	embryonic morphogenesis	Htr2b	IMP		Mouse	MGI:MGI:707955\|PMID:9165122
Biological Process	GO:0070371	ERK1 and ERK2 cascade	HTR2B	IMP		Human	PMID:19308295
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Htr2b	IMP		Mouse	MGI:MGI:86840\|PMID:8621713
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Htr2b	IMP		Mouse	MGI:MGI:4457445\|PMID:20450948
Biological Process	GO:0002031	G protein-coupled receptor internalization	Htr2b	IDA		Mouse	MGI:MGI:4821070\|PMID:17325130
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	HTR2B	IMP		Human	PMID:15625277
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	HTR2B	IMP		Human	PMID:18703043
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	HTR2B	IDA		Human	PMID:7926008
Biological Process	GO:0007507	heart development	Htr2b	IMP	MGI:MGI:1888735	Mouse	PMID:10944220
Biological Process	GO:0007507	heart development	htr2b	IMP	ZFIN:ZDB-GENO-230203-2	Zfish	PMID:35904815
Biological Process	GO:0003007	heart morphogenesis	Htr2b	IMP		Mouse	MGI:MGI:707955\|PMID:9165122
Biological Process	GO:0035733	hepatic stellate cell activation	Htr2b	IEP		Rat	PMID:16936262\|RGD:9743846
Biological Process	GO:0043647	inositol phosphate metabolic process	Htr2b	IEP		Rat	PMID:1331748\|RGD:9727450
Biological Process	GO:0014827	intestine smooth muscle contraction	HTR2B	IMP		Human	PMID:7599919
Biological Process	GO:0014827	intestine smooth muscle contraction	HTR2B	IMP		Human	PMID:9186750
Biological Process	GO:0006874	intracellular calcium ion homeostasis	HTR2B	IDA		Human	PMID:16517693
Biological Process	GO:0006874	intracellular calcium ion homeostasis	HTR2B	IDA		Human	PMID:19057895
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Htr2b	IDA		Rat	PMID:1505525\|RGD:61633
Biological Process	GO:0043066	negative regulation of apoptotic process	Htr2b	IMP		Mouse	MGI:MGI:707955\|PMID:9165122
Biological Process	GO:0010507	negative regulation of autophagy	HTR2B	IMP		Human	PMID:20099302
Biological Process	GO:0060548	negative regulation of cell death	HTR2B	IMP		Human	PMID:20099302
Biological Process	GO:0014033	neural crest cell differentiation	Htr2b	IMP		Mouse	MGI:MGI:707955\|PMID:9165122
Biological Process	GO:0001755	neural crest cell migration	Htr2b	IMP		Mouse	MGI:MGI:707955\|PMID:9165122
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	HTR2B	IDA		Human	PMID:16517693
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	HTR2B	IDA		Human	PMID:12970106
Biological Process	GO:0016310	phosphorylation	HTR2B	IMP		Human	PMID:19308295
Biological Process	GO:0051781	positive regulation of cell division	Htr2b	IMP		Mouse	MGI:MGI:86840\|PMID:8621713
Biological Process	GO:0008284	positive regulation of cell population proliferation	HTR2B	IDA		Human	PMID:15625277
Biological Process	GO:0008284	positive regulation of cell population proliferation	HTR2B	IMP		Human	PMID:15925089
Biological Process	GO:0001819	positive regulation of cytokine production	HTR2B	IDA		Human	PMID:19023134
Biological Process	GO:0001819	positive regulation of cytokine production	Htr2b	IMP		Mouse	MGI:MGI:4420536\|PMID:19023134
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	HTR2B	IMP		Human	PMID:19308295
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Htr2b	IMP		Mouse	MGI:MGI:4820706\|PMID:19308295
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	HTR2B	IDA		Human	PMID:19057895
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	HTR2B	IEP		Human	PMID:12761501
Biological Process	GO:0043406	positive regulation of MAP kinase activity	HTR2B	IDA		Human	PMID:15625277
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	HTR2B	IDA		Human	PMID:15625277
Biological Process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	HTR2B	IDA		Human	PMID:19057895
Biological Process	GO:0070528	protein kinase C signaling	HTR2B	IMP		Human	PMID:20099302
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Htr2b	IMP		Mouse	MGI:MGI:4821070\|PMID:17325130
Biological Process	GO:0050795	regulation of behavior	HTR2B	IMP		Human	PMID:21179162
Biological Process	GO:0050795	regulation of behavior	Htr2b	IMP		Mouse	MGI:MGI:4867565\|PMID:21179162
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2B	IDA		Human	PMID:15862800
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2B	IMP		Human	PMID:18566482
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2B	IMP		Human	PMID:18703043
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	HTR2B	IMP		Human	PMID:8882600
Biological Process	GO:0009410	response to xenobiotic stimulus	HTR2B	IDA		Human	PMID:15862800
Biological Process	GO:0042310	vasoconstriction	HTR2B	IMP		Human	PMID:15625277

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.