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Htr2b Gene Detail
Summary
  • Symbol
    Htr2b
  • Name
    5-hydroxytryptamine (serotonin) receptor 2B
  • Synonyms
    5-HT2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109323
    NCBI Gene: 15559
  • Gene Overview
    MyGene.info: HTR2B
Location & Maps
more
  • Sequence Map
    Chr1:86099026-86111970 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12945 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 43.94 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
    Orthology source: HomoloGene
  • Synonyms
    5-HT2B, 5-HT-2B, 5-HT(2B)
  • Links
    NCBI Gene ID: 3357
    neXtProt AC: NX_P41595

  • Chr Location
    2q36.3-q37.1; chr2:231108230-231125778 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    2 involving Htr2b
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033955 VEGA Gene Model | MGI Sequence Detail 12945 C57BL/6J ±  kb
transcript OTTMUST00000085661 VEGA | MGI Sequence Detail 2083 Not Applicable  
polypeptide OTTMUSP00000046300 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    110 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001167 5-hydroxytryptamine receptor 2B
  • InterPro Domains
    IPR000482 5-Hydroxytryptamine 2B receptor
    IPR002231 5-hydroxytryptamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 6
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38368, MGI:2138380, MGI:2138536
References
more
  • Summaries
    All 74
    Developmental Gene Expression 10
    Gene Ontology 13
    Phenotypes 29
  • Earliest
    J:3106 Loric S, et al., New mouse 5-HT2-like receptor. Expression in brain, heart and intestine. FEBS Lett. 1992 Nov 9;312(2-3):203-7
  • Latest
    J:220766 Kim K, et al., Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. 2015 Feb;156(2):444-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory