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Htr2b Gene Detail
Summary
  • Symbol
    Htr2b
  • Name
    5-hydroxytryptamine (serotonin) receptor 2B
  • Synonyms
    5-HT2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109323
    NCBI Gene: 15559
  • Gene Overview
    MyGene.info: HTR2B
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:86099026-86111970 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12945 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.94 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-HT2B, 5-HT-2B, 5-HT(2B)
  • Links
    NCBI Gene ID: 3357
    neXtProt AC: NX_P41595
    UniProt: P41595

  • Chr Location
    2q37.1; chr2:231108230-231125778 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Htr2b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 5 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    214
  • Tissues
    119
  • cDNA Data
    6
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033955 VEGA Gene Model | MGI Sequence Detail 12945 C57BL/6J ±  kb
    transcript OTTMUST00000085661 VEGA | MGI Sequence Detail 2083 Not Applicable  
    polypeptide OTTMUSP00000046300 VEGA | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      110 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 7
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38368, MGI:2138380, MGI:2138536
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 14
      Phenotypes 32
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:258484 Belmer A, et al., Positive regulation of raphe serotonin neurons by serotonin 2B receptors. Neuropsychopharmacology. 2018 Jun;43(7):1623-1632
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory