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Htr2b
Gene Detail
 Symbol
Name
ID
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
MGI:109323
Synonyms 5-HT2B
Feature Type protein coding gene
Genetic Map
Chromosome 1
43.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:86099026-86111970 bp, - strand
From VEGA annotation of GRCm38

  12945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2b

Human
homologs
Human Homolog HTR2B, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
NCBI Gene ID 3357
neXtProt AC  NX_P41595
Human Synonyms  5-HT2B, 5-HT(2B)
Human Chr (Location)  2q36.3-q37.1; chr2:231108230-231125213 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.
 
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process activation of phospholipase C activity, behavior, ...
Component cell junction, cytoplasm, ...
Function drug binding, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (204)    Tissues (113)    Images (24)
Theiler Stages: 12, 13, 14, 15, 16, 17, 19, 21, 23, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 49
In situ reporter (knock in) 47
RT-PCR 97
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(6) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033955 (Evidence)
Ensembl Gene ModelENSMUSG00000026228 (Evidence)
Entrez Gene15559 (Evidence)
UniGene439747
DFCITC1587726
DoTSDT.101723987, DT.101723988, DT.99845142
NIA Mouse Gene IndexU021555
Consensus CDS ProjectCCDS35644.1
International Mouse Knockout Project StatusHtr2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033955 VEGA Gene Model | MGI Sequence Detail 12945 C57BL/6J ±  kb
transcript OTTMUST00000085661 VEGA | MGI Sequence Detail 2083 Not Applicable 
polypeptide OTTMUSP00000046300 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000482 5-Hydroxytryptamine 2B receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001167 5-hydroxytryptamine receptor 2B
References (Earliest) J:3106 Loric S, et al., New mouse 5-HT2-like receptor. Expression in brain, heart and intestine. FEBS Lett. 1992 Nov 9;312(2-3):203-7
(Latest) J:207530 Chabbi-Achengli Y, et al., Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ss/delta in osteoblasts. PLoS One. 2013;8(9):e75783
All references(77)
Other
accession IDs
MGD-MRK-38368, MGI:2138380, MGI:2138536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory