Htr2b
Gene Detail

Symbol Name ID

Htr2b 5-hydroxytryptamine (serotonin) receptor 2B MGI:109323

Synonyms

5-HT2B

Feature Type

protein coding gene

Genetic Map

Chromosome 1

43.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:86099026-86111970 bp, - strand From VEGA annotation of GRCm38   12945 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2b

Human homologs

Human Homolog		HTR2B, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
NCBI Gene ID		3357
neXtProt AC		NX_P41595
Human Synonyms		5-HT2B, 5-HT(2B)
Human Chr (Location)		2q36.3-q37.1; chr2:231108230-231125213 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.

 

Interactions

Htr2b interacts with 43 markers (Mir32, Mir92-2, Mir125a, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (71 annotations)

Process	activation of phospholipase C activity, behavior, ...
Component	cell junction, cytoplasm, ...
Function	drug binding, G-protein alpha-subunit binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (204)    Tissues (113)    Images (24)
Theiler Stages: 12, 13, 14, 15, 16, 17, 19, 21, 23, 28

Assay Type	Results
Immunohistochemistry	11
RNA in situ	49
In situ reporter (knock in)	47
RT-PCR	97

cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(13) Genomic(2) cDNA(6) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033955 (Evidence)
Ensembl Gene Model	ENSMUSG00000026228 (Evidence)
Entrez Gene	15559 (Evidence)
UniGene	439747
DFCI	TC1587726
DoTS	DT.101723987, DT.101723988, DT.99845142
NIA Mouse Gene Index	U021555
Consensus CDS Project	CCDS35644.1
International Mouse Knockout Project Status	Htr2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033955	VEGA Gene Model | MGI Sequence Detail	12945	C57BL/6J
transcript	OTTMUST00000085661	VEGA | MGI Sequence Detail	2083	Not Applicable
polypeptide	OTTMUSP00000046300	VEGA | MGI Sequence Detail	479	Not Applicable

All sequences(38) RefSeq(10) UniProt(3)

Polymorphisms

SNPs within 2kb(101 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000482	5-Hydroxytryptamine 2B receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor family
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001167	5-hydroxytryptamine receptor 2B

References

(Earliest) J:3106 Loric S, et al., New mouse 5-HT2-like receptor. Expression in brain, heart and intestine. FEBS Lett. 1992 Nov 9;312(2-3):203-7
(Latest) J:207530 Chabbi-Achengli Y, et al., Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ss/delta in osteoblasts. PLoS One. 2013;8(9):e75783
All references(77)

Other accession IDs

MGD-MRK-38368, MGI:2138380, MGI:2138536