Htr2b MGI Mouse Gene Detail - MGI:109323 - 5-hydroxytryptamine (serotonin) receptor 2B

Htr2b Gene Detail

Symbol

Htr2b
Name

5-hydroxytryptamine (serotonin) receptor 2B
Synonyms

5-HT2B

Feature Type

protein coding gene
IDs

MGI:109323
NCBI Gene: 15559
Gene Overview

MyGene.info: HTR2B

Sequence Map

Chr1:86099026-86111970 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

12945 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.94 cM
Mapping Data

2 experiments

Human Ortholog

HTR2B, 5-hydroxytryptamine receptor 2B

Vertebrate Orthologs

10

Human Ortholog

HTR2B, 5-hydroxytryptamine receptor 2B
Orthology source: HomoloGene, HGNC
Synonyms

5-HT2B, 5-HT-2B, 5-HT(2B)
Links

HGNC:5294

NCBI Gene ID: 3357

neXtProt AC: NX_P41595

UniProt: P41595
Chr Location

2q37.1; chr2:231108230-231125778 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55492
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HTR2B
Protein SuperFamily

5-hydroxytryptamine receptor 2
Gene Tree

Htr2b

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Phenotype Summary

22 phenotypes from 4 alleles in 4 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

2 involving Htr2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.

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All GO Annotations

77
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

207
Tissues

115
cDNA Data

5
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase htr2b

ZFIN htr2b

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Htr2b interacts with 43 markers (Mir32, Mir92-2, Mir125a, ...) View All

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All Sequences

31
RefSeq

8
UniProt

3
CCDS

CCDS35644.1
UniGene

439747

			Length	Strain/Species	Flank
genomic	OTTMUSG00000033955	VEGA Gene Model \| MGI Sequence Detail	12945	C57BL/6J	± kb
transcript	OTTMUST00000085661	VEGA \| MGI Sequence Detail	2083	Not Applicable
polypeptide	OTTMUSP00000046300	VEGA \| MGI Sequence Detail	479	Not Applicable

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SNPs within 2kb

110 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000001167 5-hydroxytryptamine receptor 2B

(term hierarchy)
InterPro Domains

IPR000482 5-Hydroxytryptamine 2B receptor

IPR002231 5-hydroxytryptamine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 13

Genomic 2

cDNA 6

Primer pair 4

Other 1

Microarray probesets 3

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MGD-MRK-38368, MGI:2138380, MGI:2138536

Summaries

All 82

Developmental Gene Expression 11

Gene Ontology 14

Phenotypes 30
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:240101 Lv J, et al., 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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