Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRK3
  • Mouse genes Grk3
  • Rat genes Grk3
  • Zfish genes grk3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047696	beta-adrenergic receptor kinase activity	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Molecular Function	GO:0031748	D1 dopamine receptor binding	Grk3	IPI	RGD:2518	Rat	PMID:20837135|RGD:5685022
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk3	IDA		Mouse	PMID:1869533
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Molecular Function	GO:0005515	protein binding	GRK3	IPI	UniProtKB:P25098	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	GRK3	IPI	UniProtKB:P25098	Human	PMID:28514442
Molecular Function	GO:0004672	protein kinase activity	grk3	IGI	ZFIN:ZDB-GENE-980526-89	Zfish	PMID:18815277
Cellular Component	GO:0030424	axon	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0005929	cilium	Grk3	IDA		Rat	PMID:16374707|RGD:5685597
Cellular Component	GO:0005829	cytosol	Grk3	IDA		Rat	PMID:11751266|RGD:5685616
Cellular Component	GO:0044292	dendrite terminus	Grk3	IDA		Rat	PMID:16374707|RGD:5685597
Cellular Component	GO:0043198	dendritic shaft	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0043197	dendritic spine	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0098978	glutamatergic synapse	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0016020	membrane	Grk3	IDA		Rat	PMID:16697355|RGD:5685595
Cellular Component	GO:0045121	membrane raft	Grk3	IDA		Rat	PMID:29081032|RGD:13506833
Cellular Component	GO:0005634	nucleus	Grk3	IDA		Rat	PMID:15942958|RGD:1598733
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Grk3	IDA		Rat	PMID:20837135|RGD:5685022
Cellular Component	GO:0014069	postsynaptic density	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0098793	presynapse	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0097225	sperm midpiece	Grk3	IDA		Rat	PMID:8529092|RGD:5685625
Cellular Component	GO:0045202	synapse	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0030018	Z disc	Grk3	IDA		Rat	PMID:15584034|RGD:5685604
Biological Process	GO:0043009	chordate embryonic development	grk3	IMP	ZFIN:ZDB-MRPHLNO-100505-1	Zfish	PMID:19502428
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk3	IDA		Rat	PMID:20837135|RGD:5685022
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk3	IMP		Rat	PMID:8381966|RGD:5685621
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Grk3	IEP		Rat	PMID:29081032|RGD:13506833
Biological Process	GO:0007507	heart development	grk3	IMP	ZFIN:ZDB-MRPHLNO-090730-1	Zfish	PMID:25104355
Biological Process	GO:0003315	heart rudiment formation	grk3	IGI	ZFIN:ZDB-GENO-010411-9,ZFIN:ZDB-MRPHLNO-090730-1	Zfish	PMID:25555130
Biological Process	GO:0043647	inositol phosphate metabolic process	Grk3	IMP		Rat	PMID:17573483|RGD:5685371
Biological Process	GO:0006886	intracellular protein transport	Grk3	IMP		Rat	PMID:8276821|RGD:5685629
Biological Process	GO:0055001	muscle cell development	grk3	IGI	ZFIN:ZDB-MRPHLNO-090505-3,ZFIN:ZDB-MRPHLNO-090730-1	Zfish	PMID:21659505
Biological Process	GO:0055001	muscle cell development	grk3	IMP	ZFIN:ZDB-MRPHLNO-090730-1	Zfish	PMID:21659505
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Grk3	IDA		Rat	PMID:20837135|RGD:5685022
Biological Process	GO:0006468	protein phosphorylation	Grk3	IDA		Rat	PMID:1403099|RGD:632163
Biological Process	GO:0006468	protein phosphorylation	Grk3	IMP		Rat	PMID:8381966|RGD:5685621
Biological Process	GO:0031623	receptor internalization	GRK3	IDA		Human	PMID:20074556
Biological Process	GO:0008016	regulation of heart contraction	grk3	IMP	ZFIN:ZDB-MRPHLNO-150107-1	Zfish	PMID:25104355
Biological Process	GO:0008016	regulation of heart contraction	grk3	IMP	ZFIN:ZDB-MRPHLNO-090730-1	Zfish	PMID:25104355
Biological Process	GO:0043278	response to morphine	Grk3	IEP		Rat	PMID:29081032|RGD:13506833
Biological Process	GO:0046154	rhodopsin metabolic process	Grk3	IMP		Rat	PMID:17573483|RGD:5685371
Biological Process	GO:0007224	smoothened signaling pathway	grk3	IMP	ZFIN:ZDB-GENO-160803-6	Zfish	PMID:27113758
Biological Process	GO:0007224	smoothened signaling pathway	grk3	IGI	ZFIN:ZDB-GENE-980526-89	Zfish	PMID:18815277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern