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Gene Detail
adrenergic receptor kinase, beta 2
Synonyms 4833444A01Rik, Adrbk-2, Bark-2, beta ARK2, GRK3
Feature Type protein coding gene
Genetic Map
Chromosome 5
55.29 cM
Detailed Genetic Map ± 1 cM

Mapping data(9)
Sequence Map
Chr5:112910478-113015514 bp, - strand
From NCBI annotation of GRCm38

  105037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:21072  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: beta-adrenergic-receptor kinase
Gene Tree: Adrbk2

Human Homolog ADRBK2, adrenergic, beta, receptor kinase 2
NCBI Gene ID 157
neXtProt AC  NX_P35626
Human Synonyms  BARK2, GRK3
Human Chr (Location)  22q12.1; chr22:25564894-25729294 (+)  GRCh38
alleles, and
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Animals homozygous for a mutation of this gene appear normal and are fertile, but exhibit a lack of odorant receptor-mediated desensitization in the olfactory epithelium.
Adrbk2 interacts with 384 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (37 annotations)
Process desensitization of G-protein coupled receptor protein signaling pathway, inositol phosphate metabolic process, ...
Component axon, cilium, ...
Function ATP binding, beta-adrenergic receptor kinase activity, ...
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (110)    Tissues (44)    Images (31)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 110
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(51) cDNA(49) Other(2)
Microarray probesets(3)
Other database
Ensembl Gene ModelENSMUSG00000042249 (Evidence)
Entrez Gene320129 (Evidence)
DFCITC1583649, TC1588285, TC1608509, TC1638775
DoTSDT.110633801, DT.40158009, DT.55282523, DT.94123026
NIA Mouse Gene IndexU026583
Consensus CDS ProjectCCDS19545.1
International Mouse Knockout Project StatusAdrbk2
Representative SequencesLengthStrain/SpeciesFlank
genomic 320129 NCBI Gene Model | MGI Sequence Detail 105037 C57BL/6J ±  kb
transcript NM_001285806 RefSeq | MGI Sequence Detail 6617 C57BL/6 
polypeptide Q3UYH7 UniProt | EBI | MGI Sequence Detail 688 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(7) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(1080 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1082)
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003792 beta-adrenergic receptor kinase 2
Graphical View of Protein Domain Structure
References (Earliest) J:11373 Benovic JL, et al., Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. J Biol Chem. 1991 Aug 15;266(23):14939-46
(Latest) J:209548 Tarrant TK, et al., G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. J Leukoc Biol. 2013 Dec;94(6):1243-51
All references(53)
accession IDs
MGD-MRK-1150, MGD-MRK-1152, MGD-MRK-1497, MGI:2140993, MGI:2141228, MGI:2443434

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory