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Grk3 Gene Detail
Summary
  • Symbol
    Grk3
  • Name
    G protein-coupled receptor kinase 3
  • Synonyms
    4833444A01Rik, Adrbk2, Adrbk-2, Bark-2, beta ARK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:87941
    NCBI Gene: 320129
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112910482-113015791 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.29 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1055 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87941
protein coding gene Chr5:112910478-113018649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029911
protein coding gene Chr5:115528902-115641934 (-)
A/J MGP_AJ_G0029877
protein coding gene Chr5:111030091-111137799 (-)
AKR/J MGP_AKRJ_G0029815
protein coding gene Chr5:114545554-114664206 (-)
BALB/cJ MGP_BALBcJ_G0029888
protein coding gene Chr5:112388715-112497891 (-)
C3H/HeJ MGP_C3HHeJ_G0029608
protein coding gene Chr5:114982833-115093937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030341
protein coding gene Chr5:120027360-120142502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027570
protein coding gene Chr5:105844646-105953761 (-)
CAST/EiJ MGP_CASTEiJ_G0029016
protein coding gene Chr5:113908681-114020942 (-)
CBA/J MGP_CBAJ_G0029575
protein coding gene Chr5:124539363-124681281 (-)
DBA/2J MGP_DBA2J_G0029725
protein coding gene Chr5:111090462-111203517 (-)
FVB/NJ MGP_FVBNJ_G0029682
protein coding gene Chr5:109828983-109940748 (-)
LP/J MGP_LPJ_G0029813
protein coding gene Chr5:116091198-116205044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029713
protein coding gene Chr5:129094507-129206462 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030382
protein coding gene Chr5:113980787-114091996 (-)
PWK/PhJ MGP_PWKPhJ_G0028730
protein coding gene Chr5:109711162-109818309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028568
protein coding gene Chr5:111474996-111603006 (-)
WSB/EiJ MGP_WSBEiJ_G0029092
protein coding gene Chr5:114510369-114621437 (-)



Homology
more
  • Human Ortholog
    GRK3, G protein-coupled receptor kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRK3, G protein-coupled receptor kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRBK2, BARK2
  • Links
    NCBI Gene ID: 157
    neXtProt AC: NX_P35626
    UniProt: P35626

  • Chr Location
    22q12.1; chr22:25564894-25729294 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation of this gene appear normal and are fertile, but exhibit a lack of odorant receptor-mediated desensitization in the olfactory epithelium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042249 Ensembl Gene Model | MGI Sequence Detail 105310 C57BL/6J ±  kb
    transcript ENSMUST00000065167 Ensembl | MGI Sequence Detail 6533 Not Applicable  
    polypeptide ENSMUSP00000070445 Ensembl | MGI Sequence Detail 688 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1150, MGD-MRK-1152, MGD-MRK-1497, MGI:2140993, MGI:2141228, MGI:2443434
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:209548 Tarrant TK, et al., G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. J Leukoc Biol. 2013 Dec;94(6):1243-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory