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Grk3 Gene Detail
Summary
  • Symbol
    Grk3
  • Name
    G protein-coupled receptor kinase 3
  • Synonyms
    4833444A01Rik, Adrbk-2, Adrbk2, Bark-2, beta ARK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:87941
    NCBI Gene: 320129
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:113058344-113163518 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.29 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3333 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87941
 protein coding gene Chr5:113058344-113163657 (-)
129S1/SvImJ ENSMUSG00200022781
 protein coding gene Chr5:106801953-106907359 (-)
A/J ENSMUSG00195033972
 protein coding gene Chr5:106312125-106416657 (-)
AKR/J ENSMUSG00220051205
 protein coding gene Chr5:105826396-105931716 (-)
BALB/cJ ENSMUSG00180045374
 protein coding gene Chr5:106452366-106557783 (-)
C3H/HeJ ENSMUSG00175038915
 protein coding gene Chr5:108433361-108538800 (-)
C57BL/6NJ ENSMUSG00215029767
 protein coding gene Chr5:106457574-106562912 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027570
 protein coding gene Chr5:105844646-105953761 (-)
CAST/EiJ ENSTCUG00005020651
 protein coding gene Chr5:105635959-105742036 (-)
CBA/J ENSMUSG00210037072
 protein coding gene Chr5:107185432-107290880 (-)
DBA/2J ENSMUSG00185046933
 protein coding gene Chr5:110235829-110341304 (-)
FVB/NJ ENSMUSG00205049516
 protein coding gene Chr5:106090097-106195503 (-)
JF1/MsJ ENSUMUG00000029234
 protein coding gene Chr5:113073198-113179304 (-)
LP/J ENSMUSG00230042930
 protein coding gene Chr5:114340242-114445633 (-)
NOD/ShiLtJ ENSMUSG00190047857
 protein coding gene Chr5:106125629-106230932 (-)
NZO/HlLtJ ENSMUSG00225024406
 protein coding gene Chr5:121976625-122082026 (-)
PWK/PhJ ENSLUMG00010025351
 protein coding gene Chr5:104985346-105090827 (-)
SPRET/EiJ ENSMSPG00010044101
 protein coding gene Chr5:108244177-108351115 (-)
WSB/EiJ ENSIUOG00005040111
 protein coding gene Chr5:108827103-108932375 (-)



Homology
more
  • Human Ortholog
    GRK3, G protein-coupled receptor kinase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRK3, G protein-coupled receptor kinase 3
  • Synonyms
    ADRBK2, BARK2
  • Links
    NCBI Gene ID: 157
    UniProt: P35626

  • Chr Location
    22q12.1; chr22:25564432-25729294 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation of this gene appear normal and are fertile, but exhibit a lack of odorant receptor-mediated desensitization in the olfactory epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    44
  • cDNA Data
    49
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320129 NCBI Gene Model | MGI Sequence Detail 105175 C57BL/6J ±  kb
    transcript NM_001285806 RefSeq | MGI Sequence Detail 6617 C57BL/6  
    polypeptide Q3UYH7 UniProt | EBI | MGI Sequence Detail 688 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1150, MGD-MRK-1152, MGD-MRK-1497, MGI:2140993, MGI:2141228, MGI:2443434
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 29
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:349923 George K, et al., Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons. iScience. 2024 Jun 21;27(6):110047
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory