Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Foxo1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FOXO1
- Mouse genes Foxo1
- Rat genes Foxo1
- Zfish genes foxo1a,foxo1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	FOXO1	IDA		Human	PMID:15905404
Molecular Function	GO:0031490	chromatin DNA binding	Foxo1	IDA		Mouse	PMID:29320745
Molecular Function	GO:0003677	DNA binding	Foxo1	IDA		Mouse	PMID:12488434
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXO1	IDA		Human	PMID:17024043
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxo1	IDA		Mouse	MGI:MGI:3697295\|PMID:17090532
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxo1	IDA		Mouse	MGI:MGI:6414737\|PMID:32103177
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxo1	IDA		Mouse	PMID:29320745
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXO1	IDA		Human	PMID:17024043
Molecular Function	GO:0003700	DNA-binding transcription factor activity	FOXO1	IMP		Human	PMID:31063815
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxo1	IDA		Mouse	PMID:12488434
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxo1	IDA		Rat	PMID:10960473\|RGD:632718
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Foxo1	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Foxo1	IDA		Mouse	MGI:MGI:2388494\|PMID:12219087
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Foxo1	IDA		Mouse	PMID:17950246
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Foxo1	IGI	MGI:MGI:1890081	Mouse	PMID:19896444
Molecular Function	GO:0003676	nucleic acid binding	FOXO1	EXP		Human	PMID:18786403
Molecular Function	GO:1990841	promoter-specific chromatin binding	Foxo1	IDA		Mouse	PMID:22514318
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P61981	Human	PMID:11237865
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P63104	Human	PMID:11237865
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P03372	Human	PMID:11353774
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q923E4	Human	PMID:15220471
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q92793	Human	PMID:15220471
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q96EB6	Human	PMID:15220471
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q14192	Human	PMID:15692560
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q96EB6	Human	PMID:15692560
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q09472	Human	PMID:15890677
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P23945	Human	PMID:17030088
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q96EB6	Human	PMID:18235501
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P06493	Human	PMID:18408765
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P31749	Human	PMID:18786403
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q8IXJ6	Human	PMID:20543840
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P14921-3	Human	PMID:24419615
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q01105	Human	PMID:24983498
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P31749	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:Q92793	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FOXO1	IPI	UniProtKB:P62937	Human	PMID:31063815
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:Q6PB66	Mouse	MGI:MGI:3689757\|PMID:17050673
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P10275	Mouse	MGI:MGI:3808059\|PMID:17202144
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P37238\|UniProtKB:Q8VDQ8	Mouse	MGI:MGI:5567909\|PMID:19037106
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P53566	Mouse	MGI:MGI:3720500\|PMID:17627282
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P51450-2	Mouse	MGI:MGI:5688829\|PMID:23467085
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:Q08775	Mouse	MGI:MGI:5430843\|PMID:21471200
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P0DJI6\|UniProtKB:Q96EB6	Mouse	MGI:MGI:5426078\|PMID:22510882
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:Q8BUB4	Mouse	MGI:MGI:5693367\|PMID:18388859
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P0DJI6	Mouse	MGI:MGI:5426078\|PMID:22510882
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5914352\|PMID:28790135
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	PR:O88898	Mouse	PMID:23906066
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	PR:Q923E4	Mouse	PMID:22514318
Molecular Function	GO:0005515	protein binding	Foxo1	IPI	PR:P25233	Mouse	PMID:22514318
Molecular Function	GO:0051721	protein phosphatase 2A binding	Foxo1	IDA		Mouse	MGI:MGI:5428815\|PMID:22417654
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxo1	IDA		Mouse	MGI:MGI:3697295\|PMID:17090532
Molecular Function	GO:0043565	sequence-specific DNA binding	FOXO1	IDA		Human	PMID:12228231
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxo1	IDA		Mouse	PMID:11353388
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxo1	IDA		Rat	PMID:17916612\|RGD:2302520
Molecular Function	GO:0001223	transcription coactivator binding	Foxo1	IPI	RGD:620925	Rat	PMID:19273580\|RGD:10059650
Molecular Function	GO:0008134	transcription factor binding	Foxo1	IPI	UniProtKB:P53566	Mouse	MGI:MGI:3697295\|PMID:17090532
Molecular Function	GO:0031625	ubiquitin protein ligase binding	FOXO1	IPI	UniProtKB:O95352	Human	PMID:20543840
Cellular Component	GO:0005737	cytoplasm	FOXO1	IDA		Human	PMID:11237865
Cellular Component	GO:0005737	cytoplasm	FOXO1	IDA		Human	PMID:11311120
Cellular Component	GO:0005737	cytoplasm	FOXO1	IDA		Human	PMID:12228231
Cellular Component	GO:0005737	cytoplasm	FOXO1	IDA		Human	PMID:20543840
Cellular Component	GO:0005737	cytoplasm	FOXO1	IDA		Human	PMID:25009184
Cellular Component	GO:0005737	cytoplasm	FOXO1	IDA		Human	PMID:31063815
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	MGI:MGI:3770474\|PMID:17681146
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	MGI:MGI:5693367\|PMID:18388859
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	MGI:MGI:5567909\|PMID:19037106
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	MGI:MGI:6414737\|PMID:32103177
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	MGI:MGI:4946566\|PMID:21317886
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	PMID:12488434
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	PMID:12857750
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Mouse	PMID:16027169
Cellular Component	GO:0005737	cytoplasm	Foxo1	IDA		Rat	PMID:25183529\|RGD:10044263
Cellular Component	GO:0005829	cytosol	Foxo1	IDA		Rat	PMID:17916612\|RGD:2302520
Cellular Component	GO:0005634	nucleus	FOXO1	IDA		Human	PMID:25009184
Cellular Component	GO:0005634	nucleus	FOXO1	IDA		Human	PMID:11311120
Cellular Component	GO:0005634	nucleus	FOXO1	IDA		Human	PMID:12228231
Cellular Component	GO:0005634	nucleus	FOXO1	IDA		Human	PMID:18680538
Cellular Component	GO:0005634	nucleus	FOXO1	IDA		Human	PMID:20543840
Cellular Component	GO:0005634	nucleus	FOXO1	IDA		Human	PMID:31063815
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:3770474\|PMID:17681146
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:5567909\|PMID:19037106
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:5693367\|PMID:18388859
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:4946566\|PMID:21317886
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:6414737\|PMID:32103177
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:5914352\|PMID:28790135
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	PMID:22514318
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	PMID:21817126
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	PMID:12857750
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	PMID:16027169
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	PMID:23906066
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Mouse	PMID:12488434
Cellular Component	GO:0005634	nucleus	Foxo1	IDA		Rat	PMID:17916612\|RGD:2302520
Biological Process	GO:0006915	apoptotic process	FOXO1	IMP		Human	PMID:31063815
Biological Process	GO:0001568	blood vessel development	Foxo1	IMP	MGI:MGI:3052743	Mouse	PMID:15184386
Biological Process	GO:0001568	blood vessel development	Foxo1	IMP	MGI:MGI:2447732	Mouse	PMID:14978268
Biological Process	GO:0060070	canonical Wnt signaling pathway	Foxo1	IGI	MGI:MGI:98956	Mouse	PMID:19896444
Biological Process	GO:0060070	canonical Wnt signaling pathway	Foxo1	IGI	MGI:MGI:1890081	Mouse	PMID:19896444
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Foxo1	IEP		Rat	PMID:19443572\|RGD:10044266
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Foxo1	IEP		Rat	PMID:22417654\|RGD:10044264
Biological Process	GO:0071455	cellular response to hyperoxia	FOXO1	IDA		Human	PMID:20543840
Biological Process	GO:0032869	cellular response to insulin stimulus	Foxo1	IDA		Mouse	MGI:MGI:3770474\|PMID:17681146
Biological Process	GO:0071732	cellular response to nitric oxide	Foxo1	IDA		Mouse	MGI:MGI:5437421\|PMID:21196578
Biological Process	GO:0034599	cellular response to oxidative stress	Foxo1	IDA		Mouse	MGI:MGI:5428815\|PMID:22417654
Biological Process	GO:0009267	cellular response to starvation	FOXO1	IDA		Human	PMID:20543840
Biological Process	GO:0006974	DNA damage response	Foxo1	IDA		Mouse	MGI:MGI:5437421\|PMID:21196578
Biological Process	GO:0070166	enamel mineralization	Foxo1	IEP		Rat	PMID:25183529\|RGD:10044263
Biological Process	GO:0006094	gluconeogenesis	foxo1a	IGI	ZFIN:ZDB-GENE-020503-3	Zfish	PMID:30102881
Biological Process	GO:0042593	glucose homeostasis	Foxo1	IDA		Mouse	PMID:21317886
Biological Process	GO:0008286	insulin receptor signaling pathway	Foxo1	IMP	MGI:MGI:2447732	Mouse	PMID:12488434
Biological Process	GO:0001945	lymph vessel development	foxo1a	IGI	ZFIN:ZDB-GENE-041228-13	Zfish	PMID:26458334
Biological Process	GO:0001945	lymph vessel development	foxo1b	IGI	ZFIN:ZDB-GENE-041228-13	Zfish	PMID:26458334
Biological Process	GO:0043066	negative regulation of apoptotic process	FOXO1	IDA		Human	PMID:10871843
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Foxo1	IGI	MGI:MGI:1890081	Mouse	PMID:19896444
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Foxo1	IGI	MGI:MGI:98956	Mouse	PMID:19896444
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	Foxo1	IMP		Rat	PMID:26436652\|RGD:13210548
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Foxo1	IMP		Mouse	MGI:MGI:3770474\|PMID:17681146
Biological Process	GO:0046676	negative regulation of insulin secretion	Foxo1	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Biological Process	GO:0046676	negative regulation of insulin secretion	Foxo1	IDA		Mouse	MGI:MGI:2388494\|PMID:12219087
Biological Process	GO:0032873	negative regulation of stress-activated MAPK cascade	FOXO1	IDA		Human	PMID:19696738
Biological Process	GO:0097150	neuronal stem cell population maintenance	Foxo1	IGI	MGI:MGI:1890081	Mouse	PMID:19896444
Biological Process	GO:0043065	positive regulation of apoptotic process	FOXO1	IMP		Human	PMID:20543840
Biological Process	GO:0010508	positive regulation of autophagy	FOXO1	IMP		Human	PMID:20543840
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXO1	IDA		Human	PMID:10871843
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXO1	IDA		Human	PMID:12228231
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FOXO1	IDA		Human	PMID:7862145
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxo1	IDA		Mouse	PMID:29320745
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Foxo1	IDA		Rat	PMID:17916612\|RGD:2302520
Biological Process	GO:0045722	positive regulation of gluconeogenesis	FOXO1	IDA		Human	PMID:17024043
Biological Process	GO:0045722	positive regulation of gluconeogenesis	FOXO1	IDA		Human	PMID:25009184
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Foxo1	IMP		Mouse	PMID:12783775
Biological Process	GO:0045732	positive regulation of protein catabolic process	FOXO1	IMP		Human	PMID:20543840
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXO1	IDA		Human	PMID:10871843
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXO1	IDA		Human	PMID:12228231
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXO1	IMP		Human	PMID:27577745
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxo1	IMP		Mouse	PMID:12783775
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxo1	IGI	MGI:MGI:2669849	Mouse	PMID:17550780
Biological Process	GO:0042127	regulation of cell population proliferation	Foxo1	IMP	MGI:MGI:2447732	Mouse	PMID:12488434
Biological Process	GO:0006355	regulation of DNA-templated transcription	Foxo1	IDA		Mouse	PMID:12488434
Biological Process	GO:0006111	regulation of gluconeogenesis	Foxo1	IMP		Mouse	PMID:18497885
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	Foxo1	IGI	MGI:MGI:1890081	Mouse	PMID:19896444
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	Foxo1	IGI	MGI:MGI:1890081	Mouse	PMID:19896444
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Foxo1	IDA		Mouse	MGI:MGI:3697295\|PMID:17090532
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Foxo1	IDA		Rat	PMID:10960473\|RGD:632718
Biological Process	GO:0070542	response to fatty acid	Foxo1	IDA		Mouse	MGI:MGI:6414737\|PMID:32103177
Biological Process	GO:1902617	response to fluoride	Foxo1	IEP		Rat	PMID:25183529\|RGD:10044263
Biological Process	GO:0032868	response to insulin	Foxo1	IEP		Rat	PMID:20501667\|RGD:10045355
Biological Process	GO:0051145	smooth muscle cell differentiation	foxo1a	IMP	ZFIN:ZDB-MRPHLNO-170327-3	Zfish	PMID:28049660
Biological Process	GO:0048659	smooth muscle cell proliferation	foxo1a	IMP	ZFIN:ZDB-MRPHLNO-170327-3	Zfish	PMID:28049660
Biological Process	GO:0048745	smooth muscle tissue development	foxo1a	IMP	ZFIN:ZDB-MRPHLNO-170327-3	Zfish	PMID:28049660

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.