Foxo1
Gene Detail

Symbol Name ID

Foxo1 forkhead box O1 MGI:1890077

Synonyms

Afxh, FKHR, Fkhr1, Foxo1a

Feature Type

protein coding gene

Genetic Map

Chromosome 3

23.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:52268337-52350109 bp, + strand From VEGA annotation of GRCm38   81773 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo1

Human homologs

Human Homolog		FOXO1, forkhead box O1
NCBI Gene ID		2308
neXtProt AC		NX_Q12778
Human Synonyms		FKH1, FKHR, FOXO1A
Human Chr (Location)		13q14.1; chr13:41129801-41240734 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FOXO1

Alleles and phenotypes

All alleles(20) : Targeted(15) Gene trapped(5)
 

Homozygous null embryos die at E10.5-E11.5 from vasculature defects. Heterozygote null mice have slightly elevated glycogen levels. Conditionally targeted homozygotes display hemangiomas or defects in nave T cell homeostasis depending on the targeted ce ll type.

 
Human Diseases Modeled Using Mouse Foxo1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (54 annotations)

Process	apoptotic process, blood vessel development, ...
Component	cytoplasm, cytosol, ...
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (262)    Tissues (215)    Images (114)
Theiler Stages: 2, 3, 4, 5, 10, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	108
In situ reporter (knock in)	131
Western blot	4
RT-PCR	19

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(18) Primer pair(4) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000021250 (Evidence)
Ensembl Gene Model	ENSMUSG00000044167 (Evidence)
Entrez Gene	56458 (Evidence)
DFCI	TC1577441, TC1597455, TC1600314
DoTS	DT.101367712
NIA Mouse Gene Index	U003222
Consensus CDS Project	CCDS17343.1
International Mouse Knockout Project Status	Foxo1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021250	VEGA Gene Model | MGI Sequence Detail	81773	C57BL/6J
transcript	OTTMUST00000050335	VEGA | MGI Sequence Detail	5552	Not Applicable
polypeptide	OTTMUSP00000023486	VEGA | MGI Sequence Detail	652	Not Applicable

All sequences(44) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(410 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007640	forkhead box protein O1

References

(Earliest) J:64810 Nakae J, et al., Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999 Jun 4;274(23):15982-5
(Latest) J:192203 Balakrishnan A, et al., Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas. Dev Biol. 2013 Jan 1;373(1):118-29
All references(200)

Other accession IDs

MGI:2139839