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Foxo1
Gene Detail
Symbol

Name
ID
Foxo1
forkhead box O1
MGI:1890077
Synonyms
Afxh, FKHR, Fkhr1, Foxo1a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
23.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:52268337-52350109 bp, + strand
From VEGA annotation of GRCm38

  81773 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo1

Human
homologs
Human Homolog FOXO1, forkhead box O1
NCBI Gene ID 2308
neXtProt AC  NX_Q12778
Human Synonyms  FKH1, FKHR, FOXO1A
Human Chr (Location)  13q14.1; chr13:40555664-40666597 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOXO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(5) Targeted(15)
Incidental mutations (data from APF )
 
Homozygous null embryos die at E10.5-E11.5 from vasculature defects. Heterozygote null mice have slightly elevated glycogen levels. Conditionally targeted homozygotes display hemangiomas or defects in na´ve T cell homeostasis depending on the targeted cell type.
 
Human Diseases Modeled Using Mouse Foxo1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Foxo1 interacts with 370 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process apoptotic process, autophagy, ...
Component cytoplasm, cytosol, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (255)    Tissues (219)    Images (114)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
In situ reporter (knock in) 131
Western blot 4
RT-PCR 12
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000021250 (Evidence)
Ensembl Gene ModelENSMUSG00000044167 (Evidence)
Entrez Gene56458 (Evidence)
DFCITC1577441, TC1600314, TC1597455
DoTSDT.101367712
NIA Mouse Gene IndexU003222
Consensus CDS ProjectCCDS17343.1
International Mouse Knockout Project StatusFoxo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021250 VEGA Gene Model | MGI Sequence Detail 81773 C57BL/6J ±  kb
transcript OTTMUST00000050335 VEGA | MGI Sequence Detail 5552 Not Applicable 
polypeptide OTTMUSP00000023486 VEGA | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(440 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007640 forkhead box protein O1
References
(Earliest) J:64810 Nakae J, et al., Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999 Jun 4;274(23):15982-5
(Latest) J:213844 Mori R, et al., Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring. Am J Pathol. 2014 Sep;184(9):2465-79
All references(232)
Other
accession IDs
MGI:2139839

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory