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Foxo1
Gene Detail
Symbol

Name
ID
Foxo1
forkhead box O1
MGI:1890077
Synonyms
Afxh, FKHR, Fkhr1, Foxo1a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
23.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:52268336-52353221 bp, + strand
From VEGA annotation of GRCm38

  84886 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FOXO1
Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo1

Human
homologs
FOXO1, forkhead box O1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2308
neXtProt AC: NX_Q12778

Human Synonyms: FKH1, FKHR, FOXO1A

Human Chr (Location): 13q14.1; chr13:40555664-40666660 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FOXO1

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(5) Targeted(19)
Incidental mutations (data from APF , CvDC )
 
Homozygous null embryos die at E10.5-E11.5 from vasculature defects. Heterozygote null mice have slightly elevated glycogen levels. Conditionally targeted homozygotes display hemangiomas or defects in na´ve T cell homeostasis depending on the targeted cell type.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Foxo1 interacts with 369 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process anatomical structure morphogenesis, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (255)    Tissues (219)    Images (114)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
In situ reporter (knock in) 131
Western blot 4
RT-PCR 12
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxo1 ; ZFIN foxo1a, foxo1b    NEW 
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000021250 (Evidence)
Ensembl Gene Model ENSMUSG00000044167 (Evidence)
Entrez Gene 56458 (Evidence)
DFCI TC1577441, TC1597455, TC1600314
DoTS DT.101367712
NIA Mouse Gene Index U003222
Consensus CDS Project CCDS17343.1
International Mouse Phenotyping Consortium Status Foxo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021250 VEGA Gene Model | MGI Sequence Detail 84886 C57BL/6J ±  kb
transcript OTTMUST00000050335 VEGA | MGI Sequence Detail 8665 Not Applicable 
polypeptide OTTMUSP00000023486 VEGA | MGI Sequence Detail 652 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(466 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007640 forkhead box protein O1
References
(Earliest) J:64810 Nakae J, et al., Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999 Jun 4;274(23):15982-5
(Latest) J:221499 Skarra DV, et al., FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol. 2015 Apr 15;405:14-24
All references(246)
Other
accession IDs
MGI:2139839

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory