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Foxo1 Gene Detail
Summary
  • Symbol
    Foxo1
  • Name
    forkhead box O1
  • Synonyms
    Afxh, FKHR, Fkhr1, Foxo1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890077
    NCBI Gene: 56458
  • Gene Overview
    MyGene.info: FOXO1
Location & Maps
more
  • Sequence Map
    Chr3:52268336-52353221 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84886 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXO1, forkhead box O1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FOXO1, forkhead box O1
    Orthology source: HomoloGene
  • Synonyms
    FKH1, FKHR, FOXO1A
  • Links
    NCBI Gene ID: 2308
    neXtProt AC: NX_Q12778

  • Chr Location
    13q14.1; chr13:40555664-40666660 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FOXO1 associations

Human Disease Mouse Models
       Rhabdomyosarcoma 2; RMS2   OMIM: 268220
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    93 phenotypes from 12 alleles in 14 genetic backgrounds
    63 phenotypes from multigenic genotypes
    2 images
    130 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Gene trapped
    5
  • Radiation induced
    2
  • Targeted
    20
  • Transgenic
    2
  • Genomic Mutations
    2 involving Foxo1
  • Incidental Mutations
    APF , CvDC
Homozygous null embryos die at E10.5-E11.5 from vasculature defects. Heterozygote null mice have slightly elevated glycogen levels. Conditionally targeted homozygotes display hemangiomas or defects in nave T cell homeostasis depending on the targeted cell type.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021250 VEGA Gene Model | MGI Sequence Detail 84886 C57BL/6J ±  kb
transcript OTTMUST00000050335 VEGA | MGI Sequence Detail 8665 Not Applicable  
polypeptide OTTMUSP00000023486 VEGA | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    462 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007640 forkhead box protein O1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR030456 Fork head domain conserved site 2
    IPR032068 FOXO protein, KIX-binding domain
    IPR032067 FOXO protein, transactivation domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 23
    cDNA 18
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2139839
References
more
  • Summaries
    All 260
    Developmental Gene Expression 48
    Diseases 2
    Gene Ontology 29
    Phenotypes 130
  • Earliest
    J:64810 Nakae J, et al., Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999 Jun 4;274(23):15982-5
  • Latest
    J:229093 Luo CT, et al., Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016 Jan 28;529(7587):532-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory