Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Flt1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FLT1
- Mouse genes Flt1
- Rat genes Flt1
- Zfish genes flt1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Flt1	IDA		Rat	PMID:16086034\|RGD:1626619
Molecular Function	GO:0019838	growth factor binding	FLT1	IPI	UniProtKB:P15692	Human	PMID:10471394
Molecular Function	GO:0019838	growth factor binding	FLT1	IPI	UniProtKB:P15692	Human	PMID:11513746
Molecular Function	GO:0019838	growth factor binding	FLT1	IPI	UniProtKB:P49765-1	Human	PMID:12366396
Molecular Function	GO:0019838	growth factor binding	FLT1	IPI	UniProtKB:P49765-2	Human	PMID:12366396
Molecular Function	GO:0019838	growth factor binding	FLT1	IPI	UniProtKB:P15692	Human	PMID:1312256
Molecular Function	GO:0019838	growth factor binding	FLT1	IPI	UniProtKB:P49765-2	Human	PMID:16109918
Molecular Function	GO:0019838	growth factor binding	Flt1	IPI	RGD:731072	Rat	PMID:17651752\|RGD:2289969
Molecular Function	GO:0042802	identical protein binding	Flt1	IPI	PR:P35969	Mouse	PMID:11591653
Molecular Function	GO:0036332	placental growth factor receptor activity	FLT1	IDA		Human	PMID:12796773
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P15692	Human	PMID:10543948
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:Q12913	Human	PMID:12771128
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P15692-4	Human	PMID:1312256
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P49763	Human	PMID:14684734
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:Q12913	Human	PMID:16893970
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P22681	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P15692	Human	PMID:20660291
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P49763	Human	PMID:20660291
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P27986	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P46109	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P27986	Human	PMID:7657594
Molecular Function	GO:0005515	protein binding	FLT1	IPI	UniProtKB:P15692	Human	PMID:9393862
Molecular Function	GO:0005515	protein binding	Flt1	IPI	UniProtKB:Q8R464	Mouse	MGI:MGI:6271409\|PMID:25893857
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Flt1	IDA		Rat	PMID:16086034\|RGD:1626619
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT1	IMP		Human	PMID:11312102
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT1	IDA		Human	PMID:1312256
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT1	IDA		Human	PMID:15952180
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT1	IDA		Human	PMID:8605350
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT1	IDA		Human	PMID:9299537
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	Flt1	IDA		Mouse	PMID:8356051
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	Flt1	IMP		Rat	PMID:15785231\|RGD:1626621
Cellular Component	GO:0015629	actin cytoskeleton	FLT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	Flt1	IDA		Mouse	PMID:25184477
Cellular Component	GO:0005615	extracellular space	Flt1	IDA		Rat	PMID:23804076\|RGD:10402115
Cellular Component	GO:0005925	focal adhesion	FLT1	HDA		Human	PMID:21423176
Cellular Component	GO:0005634	nucleus	Flt1	IDA		Mouse	PMID:22886301
Cellular Component	GO:0005886	plasma membrane	FLT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FLT1	IDA		Human	PMID:11513746
Cellular Component	GO:0005886	plasma membrane	Flt1	IDA		Rat	PMID:17651752\|RGD:2289969
Cellular Component	GO:0043235	receptor complex	FLT1	IDA		Human	PMID:23382219
Biological Process	GO:0007568	aging	Flt1	IEP		Rat	PMID:16617130\|RGD:10402145
Biological Process	GO:0001525	angiogenesis	Flt1	IMP	MGI:MGI:1857717	Mouse	PMID:14982871
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-070810-6	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	flt1	IMP	ZFIN:ZDB-MRPHLNO-110531-3	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-990415-273	Zfish	PMID:28071661
Biological Process	GO:0001525	angiogenesis	flt1	IMP	ZFIN:ZDB-GENO-170418-6	Zfish	PMID:28071661
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-980526-326	Zfish	PMID:28071661
Biological Process	GO:0001525	angiogenesis	flt1	IMP	ZFIN:ZDB-GENO-170419-3	Zfish	PMID:28071661
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-040303-4	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-041014-73	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-000705-1,ZFIN:ZDB-GENE-070810-6	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-070112-1042	Zfish	PMID:28071661
Biological Process	GO:0001525	angiogenesis	flt1	IGI	ZFIN:ZDB-GENE-040303-4,ZFIN:ZDB-GENE-070810-6	Zfish	PMID:28087639
Biological Process	GO:0001568	blood vessel development	flt1	IMP	ZFIN:ZDB-GENO-170418-6	Zfish	PMID:28071661
Biological Process	GO:0048514	blood vessel morphogenesis	Flt1	IMP		Mouse	MGI:MGI:74275\|PMID:7596436
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Flt1	IMP	MGI:MGI:1857717	Mouse	PMID:14982871
Biological Process	GO:0016477	cell migration	FLT1	IMP		Human	PMID:8605350
Biological Process	GO:0016477	cell migration	Flt1	IMP		Mouse	MGI:MGI:1277612\|PMID:9689083
Biological Process	GO:0016477	cell migration	Flt1	IGI	MGI:MGI:103178	Mouse	PMID:15601856
Biological Process	GO:0071456	cellular response to hypoxia	Flt1	IEP		Rat	PMID:11981751\|RGD:634296
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	FLT1	IDA		Human	PMID:8605350
Biological Process	GO:0048598	embryonic morphogenesis	Flt1	IMP		Mouse	MGI:MGI:74275\|PMID:7596436
Biological Process	GO:0061966	establishment of left/right asymmetry	flt1	IMP	ZFIN:ZDB-GENO-190830-2	Zfish	PMID:30446628
Biological Process	GO:0061966	establishment of left/right asymmetry	flt1	IGI	ZFIN:ZDB-GENO-190830-5	Zfish	PMID:30446628
Biological Process	GO:0061966	establishment of left/right asymmetry	flt1	IGI	ZFIN:ZDB-GENO-190830-7	Zfish	PMID:30446628
Biological Process	GO:0061966	establishment of left/right asymmetry	flt1	IMP	ZFIN:ZDB-GENO-190830-4	Zfish	PMID:30446628
Biological Process	GO:0007565	female pregnancy	Flt1	IEP		Rat	PMID:20026766\|RGD:10402123
Biological Process	GO:1990384	hyaloid vascular plexus regression	Flt1	IMP		Mouse	MGI:MGI:6359287\|PMID:30936473
Biological Process	GO:0030522	intracellular receptor signaling pathway	Flt1	IMP		Rat	PMID:16086034\|RGD:1626619
Biological Process	GO:0097421	liver regeneration	Flt1	IEP		Rat	PMID:16162160\|RGD:10402121
Biological Process	GO:0002548	monocyte chemotaxis	FLT1	IDA		Human	PMID:18079407
Biological Process	GO:0002548	monocyte chemotaxis	FLT1	IDA		Human	PMID:8605350
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	Flt1	IDA		Rat	PMID:23804076\|RGD:10402115
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	FLT1	IGI	RNAcentral:URS000016D2D4_9606,RNAcentral:URS000058760A_9606	Human	PMID:22955733
Biological Process	GO:1904046	negative regulation of vascular endothelial growth factor production	Flt1	IDA		Rat	PMID:23804076\|RGD:10402115
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FLT1	IDA		Human	PMID:11513746
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FLT1	IDA		Human	PMID:9299537
Biological Process	GO:0045766	positive regulation of angiogenesis	FLT1	IMP		Human	PMID:14633857
Biological Process	GO:0045766	positive regulation of angiogenesis	FLT1	IMP		Human	PMID:28637396
Biological Process	GO:0030335	positive regulation of cell migration	FLT1	IDA		Human	PMID:8605350
Biological Process	GO:0030335	positive regulation of cell migration	Flt1	IMP		Rat	PMID:17651752\|RGD:2289969
Biological Process	GO:0060252	positive regulation of glial cell proliferation	Flt1	IMP		Rat	PMID:18482723\|RGD:10402148
Biological Process	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	Flt1	IMP	MGI:MGI:1857717	Mouse	PMID:18772315
Biological Process	GO:0043406	positive regulation of MAP kinase activity	FLT1	IDA		Human	PMID:9299537
Biological Process	GO:0043410	positive regulation of MAPK cascade	FLT1	IDA		Human	PMID:9299537
Biological Process	GO:0043410	positive regulation of MAPK cascade	Flt1	IMP		Rat	PMID:12062723\|RGD:1582498
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	FLT1	IMP		Human	PMID:11312102
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	FLT1	IMP		Human	PMID:14633857
Biological Process	GO:0010863	positive regulation of phospholipase C activity	FLT1	IMP		Human	PMID:11312102
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Flt1	IDA		Rat	PMID:12062723\|RGD:1582498
Biological Process	GO:0048597	post-embryonic camera-type eye morphogenesis	Flt1	IGI	MGI:MGI:96683	Mouse	PMID:22426483
Biological Process	GO:0046777	protein autophosphorylation	FLT1	IDA		Human	PMID:11513746
Biological Process	GO:0046777	protein autophosphorylation	FLT1	IDA		Human	PMID:9299537
Biological Process	GO:0006468	protein phosphorylation	Flt1	IDA		Rat	PMID:16086034\|RGD:1626619
Biological Process	GO:0008016	regulation of heart contraction	flt1	IMP	ZFIN:ZDB-MRPHLNO-050906-4	Zfish	PMID:15998812
Biological Process	GO:0006940	regulation of smooth muscle contraction	Flt1	IDA		Rat	PMID:12062723\|RGD:1582498
Biological Process	GO:0014823	response to activity	Flt1	IEP		Rat	PMID:16617130\|RGD:10402145
Biological Process	GO:0032355	response to estradiol	Flt1	IEP		Rat	PMID:11732982\|RGD:10402151
Biological Process	GO:0045471	response to ethanol	Flt1	IEP		Rat	PMID:11842056\|RGD:10402149
Biological Process	GO:0001666	response to hypoxia	Flt1	IMP	MGI:MGI:1857717	Mouse	PMID:18772315
Biological Process	GO:0001666	response to hypoxia	Flt1	IDA		Rat	PMID:12062723\|RGD:1582498
Biological Process	GO:0001666	response to hypoxia	Flt1	IEP		Rat	PMID:20026766\|RGD:10402123
Biological Process	GO:0002040	sprouting angiogenesis	Flt1	IMP	MGI:MGI:1857717	Mouse	PMID:19758562
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IGI	ZFIN:ZDB-GENO-121130-2,ZFIN:ZDB-MRPHLNO-050906-5	Zfish	PMID:21802375
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IMP	ZFIN:ZDB-MRPHLNO-110921-6	Zfish	PMID:21802375
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IMP	ZFIN:ZDB-MRPHLNO-110531-3	Zfish	PMID:21521739
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IMP	ZFIN:ZDB-MRPHLNO-050906-5	Zfish	PMID:21802375
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IGI	ZFIN:ZDB-GENO-121130-2,ZFIN:ZDB-MRPHLNO-110921-6	Zfish	PMID:21802375
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IGI	ZFIN:ZDB-GENO-121114-10	Zfish	PMID:22581286
Biological Process	GO:0002040	sprouting angiogenesis	flt1	IMP	ZFIN:ZDB-MRPHLNO-050906-4	Zfish	PMID:22955733
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	FLT1	IMP		Human	PMID:11312102
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	FLT1	IDA		Human	PMID:1312256
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	FLT1	IDA		Human	PMID:9299537
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Flt1	IMP	MGI:MGI:1934260	Mouse	PMID:9689083
Biological Process	GO:0036323	vascular endothelial growth factor receptor-1 signaling pathway	FLT1	IDA		Human	PMID:15952180
Biological Process	GO:0001570	vasculogenesis	flt1	IMP	ZFIN:ZDB-MRPHLNO-050906-4	Zfish	PMID:15998812
Biological Process	GO:0060841	venous blood vessel development	flt1	IMP	ZFIN:ZDB-GENO-170223-2	Zfish	PMID:27852438

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.