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Flt1
Gene Detail
Symbol

Name
ID
Flt1
FMS-like tyrosine kinase 1
MGI:95558
Synonyms
Flt-1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR1, VEGFR-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
87.01 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:147561604-147726011 bp, - strand
From VEGA annotation of GRCm38

  164408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134179  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: FLT1
Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Flt1

Human
homologs
FLT1, fms-related tyrosine kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2321
neXtProt AC: NX_P17948

Human Synonyms: FLT, FLT-1, VEGFR1, VEGFR-1

Human Chr (Location): 13q12; chr13:28300346-28495128 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit an excess of hemangioblasts resulting in an overgrowth of endothelial cells, abnormalities of vascular channels and blood islands, and lethality at the mid-somite developmental stage.
 
Interactions
Flt1 interacts with 411 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component endosome, focal adhesion, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (142 records)
Data Summary: Results (289)    Tissues (159)    Images (100)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 140
In situ reporter (knock in) 35
RT-PCR 114
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN flt1    NEW 
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(27) Primer pair(12) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000021385 (Evidence)
Ensembl Gene Model ENSMUSG00000029648 (Evidence)
Entrez Gene 14254 (Evidence)
DFCI TC1578473, TC1583060, TC1596966, TC1623464, TC1635406, TC1642026
DoTS DT.40179114, DT.490904, DT.55178249, DT.55283283, DT.94212843
NIA Mouse Gene Index U026967
EC 2.7.10.1
Consensus CDS Project CCDS19879.1
International Mouse Phenotyping Consortium Status Flt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021385 VEGA Gene Model | MGI Sequence Detail 164408 C57BL/6J ±  kb
transcript OTTMUST00000050693 VEGA | MGI Sequence Detail 6895 Not Applicable 
polypeptide OTTMUSP00000023727 VEGA | MGI Sequence Detail 1333 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(590 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
InterPro IPR009135 Tyrosine-protein kinase, vascular endothelial growth factor receptor 1 (VEGFR1), N-terminal
Protein Ontology PR:000007563 vascular endothelial growth factor receptor 1
References
(Earliest) J:36463 Raz V, et al., PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors. Oncogene. 1991 May;6(5):753-60
(Latest) J:220538 Licht T, et al., Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity. J Clin Invest. 2015 Mar 2;125(3):1319-28
All references(254)
Other
accession IDs
MGD-MRK-9832, MGD-MRK-9836, MGI:2140833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory