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Gene Detail
FMS-like tyrosine kinase 1
Synonyms Flt-1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR1, VEGFR-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
87.01 cM, cytoband G
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr5:147561604-147726011 bp, - strand
From VEGA annotation of GRCm38

  164408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:134179  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vascular endothelial growth factor receptor
Gene Tree: Flt1

Human Homolog FLT1, fms-related tyrosine kinase 1
NCBI Gene ID 2321
neXtProt AC  NX_P17948
Human Synonyms  FLT, FLT-1, VEGFR1, VEGFR-1
Human Chr (Location)  13q12; chr13:28300346-28495128 (-)  GRCh38
alleles, and
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for targeted null mutations exhibit an excess of hemangioblasts resulting in an overgrowth of endothelial cells, abnormalities of vascular channels and blood islands, and lethality at the mid-somite developmental stage.
Flt1 interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (60 annotations)
Process angiogenesis, blood vessel morphogenesis, ...
Component endosome, focal adhesion, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Literature Summary: (140 records)
Data Summary: Results (249)    Tissues (134)    Images (78)
Theiler Stages: 11, 12, 13, 14, 15, 17, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 135
RT-PCR 114
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(40) Genomic(1) cDNA(26) Primer pair(12) Other(1)
Microarray probesets(8)
Other database
VEGA Gene ModelOTTMUSG00000021385 (Evidence)
Ensembl Gene ModelENSMUSG00000029648 (Evidence)
Entrez Gene14254 (Evidence)
DFCITC1578473, TC1583060, TC1596966, TC1623464, TC1635406, TC1642026
DoTSDT.40179114, DT.490904, DT.55178249, DT.55283283, DT.94212843
NIA Mouse Gene IndexU026967
Consensus CDS ProjectCCDS19879.1
International Mouse Knockout Project StatusFlt1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021385 VEGA Gene Model | MGI Sequence Detail 164408 C57BL/6J ±  kb
transcript OTTMUST00000050693 VEGA | MGI Sequence Detail 6895 Not Applicable 
polypeptide OTTMUSP00000023727 VEGA | MGI Sequence Detail 1333 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(8) UniProt(8)
Polymorphisms SNPs within 2kb(590 from dbSNP Build 137)
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
InterPro IPR009135 Tyrosine-protein kinase, vascular endothelial growth factor receptor 1 (VEGFR1), N-terminal
Protein Ontology PR:000007563 vascular endothelial growth factor receptor 1
References (Earliest) J:36463 Raz V, et al., PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors. Oncogene. 1991 May;6(5):753-60
(Latest) J:208348 Fantin A, et al., Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development. 2014 Feb;141(3):556-62
All references(254)
accession IDs
MGD-MRK-9832, MGD-MRK-9836, MGI:2140833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory