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Flt1 Gene Detail
Summary
  • Symbol
    Flt1
  • Name
    FMS-like tyrosine kinase 1
  • Synonyms
    Flt-1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR1, VEGFR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95558
    NCBI Gene: 14254
  • Gene Overview
    MyGene.info: FLT1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147562196-147726005 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 87.01 cM, cytoband G
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95558
protein coding gene Chr5:147561604-147726011 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030391
protein coding gene Chr5:153239322-153417102 (-)
A/J MGP_AJ_G0030364
protein coding gene Chr5:146733377-146901260 (-)
AKR/J MGP_AKRJ_G0030291
protein coding gene Chr5:151244298-151413430 (-)
BALB/cJ MGP_BALBcJ_G0030373
protein coding gene Chr5:147948976-148120605 (-)
C3H/HeJ MGP_C3HHeJ_G0030087
protein coding gene Chr5:152221203-152389205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030828
protein coding gene Chr5:158843447-159036006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028041
protein coding gene Chr5:141139974-141303106 (-)
CAST/EiJ MGP_CASTEiJ_G0029489
protein coding gene Chr5:151786890-151966819 (-)
CBA/J MGP_CBAJ_G0030065
protein coding gene Chr5:165502094-165689832 (-)
DBA/2J MGP_DBA2J_G0030209
protein coding gene Chr5:146411809-146581167 (-)
FVB/NJ MGP_FVBNJ_G0030163
protein coding gene Chr5:145614493-145783643 (-)
LP/J MGP_LPJ_G0030296
protein coding gene Chr5:153926384-154108220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030199
protein coding gene Chr5:167725300-167913943 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030858
protein coding gene Chr5:151153206-151324763 (-)
PWK/PhJ MGP_PWKPhJ_G0029203
protein coding gene Chr5:145519256-145694160 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029039
protein coding gene Chr5:148469187-148658525 (-)
WSB/EiJ MGP_WSBEiJ_G0029566
protein coding gene Chr5:151965060-152139832 (-)



Homology
more
  • Human Ortholog
    FLT1, fms related tyrosine kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FLT1, fms related tyrosine kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FLT, FLT-1, VEGFR1, VEGFR-1
  • Links
    NCBI Gene ID: 2321
    neXtProt AC: NX_P17948
    UniProt: P17948

  • Chr Location
    13q12.3; chr13:28300346-28495128 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 9 alleles in 12 genetic backgrounds
    17 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit an excess of hemangioblasts resulting in an overgrowth of endothelial cells, abnormalities of vascular channels and blood islands, and lethality at the mid-somite developmental stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14254 NCBI Gene Model | MGI Sequence Detail 163810 C57BL/6J ±  kb
    transcript NM_010228 RefSeq | MGI Sequence Detail 6895 C57BL/6  
    polypeptide P35969 UniProt | EBI | MGI Sequence Detail 1333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 30
      Primer pair 15
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-9832, MGD-MRK-9836, MGI:2140833
    References
    more
    • Summaries
      All 324
      Developmental Gene Expression 178
      Gene Ontology 17
      Phenotypes 69
    • Earliest
      J:36463 Raz V, et al., PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors. Oncogene. 1991 May;6(5):753-60
    • Latest
      J:266234 Wylie LA, et al., Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions. Dev Biol. 2018 Oct 15;442(2):199-209

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory