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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Fgf2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042056chemoattractant activityFGF2IDAHumanPMID:18059339
Molecular FunctionGO:0019956chemokine bindingFGF2IPIUniProtKB:O43927HumanPMID:11708770
Molecular FunctionGO:0005125cytokine activityFGF2IDAHumanPMID:18059339
Molecular FunctionGO:0005104fibroblast growth factor receptor bindingFGF2IPIUniProtKB:P21802HumanPMID:10830168
Molecular FunctionGO:0005104fibroblast growth factor receptor bindingFGF2IPIUniProtKB:P16092HumanPMID:2161540
Molecular FunctionGO:0005104fibroblast growth factor receptor bindingFgf2IPIUniProtKB:P21803RatPMID:10766846|RGD:8553993
Molecular FunctionGO:0005104fibroblast growth factor receptor bindingFgf2IPIUniProtKB:Q498D6RatPMID:10766846|RGD:8553993
Molecular FunctionGO:0008083growth factor activityFGF2IDAHumanPMID:18059339
Molecular FunctionGO:0008083growth factor activityFGF2IDAHumanPMID:26451614
Molecular FunctionGO:0008083growth factor activityFgf2IDAMousePMID:15608665
Molecular FunctionGO:0042802identical protein bindingFGF2IPIUniProtKB:P09038HumanPMID:11708770
Molecular FunctionGO:0005178integrin bindingFGF2IDAHumanPMID:28302677
Molecular FunctionGO:0030374nuclear receptor coactivator activityFGF2IDAHumanPMID:17500071
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362HumanPMID:10490103
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P21802HumanPMID:10830168
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362HumanPMID:11030354
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:Q9BZZ5HumanPMID:11075807
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P21802HumanPMID:11390973
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P39019HumanPMID:11716516
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:Q86XR8HumanPMID:12717444
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362HumanPMID:14613973
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:Q14512HumanPMID:16257968
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362-7HumanPMID:17086194
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P29466HumanPMID:18329368
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P26022HumanPMID:20363749
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P26022HumanPMID:22267482
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362-14HumanPMID:23597562
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362HumanPMID:23597563
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362HumanPMID:26267536
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P11362HumanPMID:35384245
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P21802HumanPMID:35384245
Molecular FunctionGO:0005515protein bindingFGF2IPIUniProtKB:P21802-1HumanPMID:9700203
Molecular FunctionGO:0005515protein bindingFgf2IPIUniProtKB:O70514|UniProtKB:Q1HCM0MouseMGI:MGI:4949582|PMID:20851768
Molecular FunctionGO:0005515protein bindingFgf2IPIUniProtKB:Q9CXL7MouseMGI:MGI:6103145|PMID:28323137
Molecular FunctionGO:0005515protein bindingFgf2IPIPR:Q91V87MousePMID:12813049
Molecular FunctionGO:0005515protein bindingFgf2IPIPR:P21803MousePMID:8393815
Molecular FunctionGO:0005515protein bindingFgf2IPIRGD:620755RatPMID:12397076|RGD:634122
Molecular FunctionGO:0090722receptor-receptor interactionFGF2IDAHumanPMID:24157794
Cellular ComponentGO:0005737cytoplasmFgf2IDARatPMID:7508717|RGD:2290306
Cellular ComponentGO:0005615extracellular spaceFGF2IDAHumanPMID:2161540
Cellular ComponentGO:0005615extracellular spaceFgf2IDAMousePMID:15576401
Cellular ComponentGO:0005615extracellular spaceFgf2IDAMousePMID:12417662
Cellular ComponentGO:0005615extracellular spaceFgf2IDARatPMID:21543745|RGD:25440477
Cellular ComponentGO:0005634nucleusFgf2IDARatPMID:7508717|RGD:2290306
Biological ProcessGO:0007568agingFgf2IEPRatPMID:9356923|RGD:8655566
Biological ProcessGO:0001525angiogenesisFgf2IGIMGI:MGI:97306MousePMID:16648142
Biological ProcessGO:0060978angiogenesis involved in coronary vascular morphogenesisFgf2IMPRatPMID:11397779|RGD:8655634
Biological ProcessGO:0001658branching involved in ureteric bud morphogenesisFGF2IDAHumanPMID:12631064
Biological ProcessGO:0060070canonical Wnt signaling pathwayFgf2IDAMousePMID:16858399
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisFGF2IDAHumanPMID:18059339
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisFGF2IGIUniProtKB:Q9UQL6HumanPMID:19351956
Biological ProcessGO:0008283cell population proliferationFgf2IGIMGI:MGI:97363MousePMID:15509736
Biological ProcessGO:0008283cell population proliferationFgf2IGIMGI:MGI:96522MousePMID:15509736
Biological ProcessGO:0008283cell population proliferationFgf2IDAMousePMID:16141225
Biological ProcessGO:0008283cell population proliferationFgf2IGIMGI:MGI:98297MousePMID:10027293
Biological ProcessGO:0008283cell population proliferationFgf2IGIMGI:MGI:95729MousePMID:20570969
Biological ProcessGO:0008283cell population proliferationFgf2IGIMGI:MGI:95290MousePMID:15051883
Biological ProcessGO:0071260cellular response to mechanical stimulusFgf2IEPRatPMID:19012730|RGD:8662390
Biological ProcessGO:0021930cerebellar granule cell precursor proliferationFgf2IDAMousePMID:10027293
Biological ProcessGO:0060591chondroblast differentiationFGF2IDAHumanPMID:17167778
Biological ProcessGO:0060128corticotropin hormone secreting cell differentiationFgf2IDAMousePMID:9463347
Biological ProcessGO:0009792embryo development ending in birth or egg hatchingFgf2IMPRatPMID:19476451|RGD:2315829
Biological ProcessGO:0043542endothelial cell migrationFgf2IDAMousePMID:16291864
Biological ProcessGO:0001935endothelial cell proliferationFgf2IDAMousePMID:16291864
Biological ProcessGO:0050673epithelial cell proliferationFgf2IGIMGI:MGI:97363MousePMID:15509736
Biological ProcessGO:0050673epithelial cell proliferationFgf2IGIMGI:MGI:96522MousePMID:15509736
Biological ProcessGO:0050673epithelial cell proliferationFgf2IDAMousePMID:17187775
Biological ProcessGO:0070371ERK1 and ERK2 cascadeFgf2IDAMousePMID:16858399
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IPIUniProtKB:P21802HumanPMID:10830168
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IGIUniProtKB:P16092HumanPMID:2161540
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IGIUniProtKB:P11362HumanPMID:8663044
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IGIUniProtKB:P21802HumanPMID:8663044
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IDAHumanPMID:16774925
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IDAHumanPMID:17500071
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IGIRNAcentral:URS000058BB84_9606,UniProtKB:P11362HumanPMID:26451614
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFGF2IDAHumanPMID:31915155
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFgf2IPIUniProtKB:P21803RatPMID:10766846|RGD:8553993
Biological ProcessGO:0008543fibroblast growth factor receptor signaling pathwayFgf2IPIUniProtKB:Q498D6RatPMID:10766846|RGD:8553993
Biological ProcessGO:0010001glial cell differentiationFgf2IMPMGI:MGI:2384003MousePMID:12878680
Biological ProcessGO:0014843growth factor dependent regulation of skeletal muscle satellite cell proliferationFGF2IMPHumanPMID:18602469
Biological ProcessGO:0030214hyaluronan catabolic processFGF2IDAHumanPMID:19577615
Biological ProcessGO:0042491inner ear auditory receptor cell differentiationFgf2IDAMousePMID:12417662
Biological ProcessGO:0032958inositol phosphate biosynthetic processFGF2IDAHumanPMID:20011604
Biological ProcessGO:0070121Kupffer's vesicle developmentfgf2IGIZFIN:ZDB-MRPHLNO-060111-5,ZFIN:ZDB-MRPHLNO-100621-9ZfishPMID:24046323
Biological ProcessGO:0030324lung developmentFgf2IGIMGI:MGI:98297MousePMID:17187775
Biological ProcessGO:0030324lung developmentFgf2IDAMousePMID:15576401
Biological ProcessGO:1904977lymphatic endothelial cell migrationFgf2IDAMousePMID:16291864
Biological ProcessGO:0060644mammary gland epithelial cell differentiationFgf2IDAMousePMID:1376141
Biological ProcessGO:0043537negative regulation of blood vessel endothelial cell migrationFGF2IDAHumanPMID:18555217
Biological ProcessGO:0060548negative regulation of cell deathFGF2IDAHumanPMID:12631064
Biological ProcessGO:0008285negative regulation of cell population proliferationFgf2IGIMGI:MGI:98297MousePMID:10027293
Biological ProcessGO:0010764negative regulation of fibroblast migrationFGF2IDAHumanPMID:19577615
Biological ProcessGO:2000647negative regulation of stem cell proliferationFgf2IGIMGI:MGI:95729MousePMID:20570969
Biological ProcessGO:0061045negative regulation of wound healingFGF2IDAHumanPMID:19577615
Biological ProcessGO:0007405neuroblast proliferationFgf2IGIMGI:MGI:95290MousePMID:15051883
Biological ProcessGO:0060563neuroepithelial cell differentiationFgf2IDAMousePMID:12417662
Biological ProcessGO:0001759organ inductionFgf2IDAMousePMID:15576401
Biological ProcessGO:0001649osteoblast differentiationFgf2IGIMGI:MGI:95729MousePMID:20570969
Biological ProcessGO:0038001paracrine signalingFgf2IDARatPMID:28679962|RGD:13601991
Biological ProcessGO:0006661phosphatidylinositol biosynthetic processFGF2IDAHumanPMID:20011604
Biological ProcessGO:0045766positive regulation of angiogenesisFGF2IDAHumanPMID:16774925
Biological ProcessGO:0045766positive regulation of angiogenesisFGF2IGIUniProtKB:Q9H3U7HumanPMID:16774925
Biological ProcessGO:0045766positive regulation of angiogenesisFGF2IDAHumanPMID:20011604
Biological ProcessGO:0045766positive regulation of angiogenesisFGF2IDAHumanPMID:28302677
Biological ProcessGO:0045766positive regulation of angiogenesisFgf2IGIMGI:MGI:97306MousePMID:16648142
Biological ProcessGO:0045766positive regulation of angiogenesisFgf2IDAMousePMID:14998491
Biological ProcessGO:0045766positive regulation of angiogenesisFgf2IGIMGI:MGI:102709MousePMID:12759260
Biological ProcessGO:0045766positive regulation of angiogenesisFgf2IDAMousePMID:14702107
Biological ProcessGO:0045766positive regulation of angiogenesisFgf2IGIMGI:MGI:98297MousePMID:17187775
Biological ProcessGO:0045766positive regulation of angiogenesisFgf2IDAMousePMID:16648142
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationFGF2IDAHumanPMID:18555217
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationFGF2IDAHumanPMID:20011604
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationFGF2IGIRNAcentral:URS00000F0F49_9606,RNAcentral:URS00000F6E49_9606,UniProtKB:P11362HumanPMID:23263626
Biological ProcessGO:0043536positive regulation of blood vessel endothelial cell migrationFGF2IDAHumanPMID:28302677
Biological ProcessGO:0090263positive regulation of canonical Wnt signaling pathwayFgf2IDAMousePMID:16858399
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationFGF2IDAHumanPMID:9553078
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationFgf2IDARatPMID:8603495|RGD:8655650
Biological ProcessGO:0042660positive regulation of cell fate specificationFGF2IDAHumanPMID:18635606
Biological ProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisFGF2IDAHumanPMID:28302677
Biological ProcessGO:0008284positive regulation of cell population proliferationFGF2IDAHumanPMID:2161540
Biological ProcessGO:0008284positive regulation of cell population proliferationFGF2IGIUniProtKB:P11362HumanPMID:8663044
Biological ProcessGO:0008284positive regulation of cell population proliferationFGF2IGIUniProtKB:P21802HumanPMID:8663044
Biological ProcessGO:0008284positive regulation of cell population proliferationFgf2IDAMousePMID:9463347
Biological ProcessGO:0008284positive regulation of cell population proliferationFgf2IDARatPMID:12000311|RGD:728688
Biological ProcessGO:0021940positive regulation of cerebellar granule cell precursor proliferationFgf2IDAMousePMID:10027293
Biological ProcessGO:2000573positive regulation of DNA biosynthetic processFGF2IDAHumanPMID:16774925
Biological ProcessGO:2000573positive regulation of DNA biosynthetic processFGF2IGIUniProtKB:Q9H3U7HumanPMID:16774925
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionFGF2IDAHumanPMID:17500071
Biological ProcessGO:2001028positive regulation of endothelial cell chemotaxisFGF2IGIUniProtKB:Q9H3U7HumanPMID:16774925
Biological ProcessGO:2000546positive regulation of endothelial cell chemotaxis to fibroblast growth factorFGF2IDAHumanPMID:16756958
Biological ProcessGO:0010595positive regulation of endothelial cell migrationFGF2IDAHumanPMID:31915155
Biological ProcessGO:0010595positive regulation of endothelial cell migrationFgf2IDAMousePMID:16291864
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationFGF2IDAHumanPMID:16756958
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationFGF2IMPHumanPMID:18059339
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationFGF2IDAHumanPMID:31915155
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationFgf2IDAMousePMID:16291864
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationFgf2IDAMousePMID:17187775
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationFgf2IGIMGI:MGI:97363MousePMID:15509736
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationFgf2IGIMGI:MGI:96522MousePMID:15509736
Biological ProcessGO:1905278positive regulation of epithelial tube formationFGF2IDAHumanPMID:31915155
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeFGF2IDAHumanPMID:17167778
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeFgf2IDAMouseMGI:MGI:6414698|PMID:29501879
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeFgf2IDAMousePMID:16858399
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeFgf2IDARatPMID:19952283|RGD:2325174
Biological ProcessGO:0010628positive regulation of gene expressionFgf2IDAMousePMID:9244299
Biological ProcessGO:0045609positive regulation of inner ear auditory receptor cell differentiationFgf2IDAMousePMID:12417662
Biological ProcessGO:1902748positive regulation of lens fiber cell differentiationFGF2IDAHumanPMID:29501879
Biological ProcessGO:0043406positive regulation of MAP kinase activityFGF2IDAHumanPMID:16756958
Biological ProcessGO:0043410positive regulation of MAPK cascadeFGF2IDAHumanPMID:26451614
Biological ProcessGO:0043410positive regulation of MAPK cascadeFGF2IDAHumanPMID:31915155
Biological ProcessGO:0043410positive regulation of MAPK cascadeFgf2IDAMousePMID:16339969
Biological ProcessGO:0002052positive regulation of neuroblast proliferationFgf2IGIMGI:MGI:95290MousePMID:15051883
Biological ProcessGO:1902913positive regulation of neuroepithelial cell differentiationFgf2IDAMousePMID:12417662
Biological ProcessGO:0045669positive regulation of osteoblast differentiationFgf2IGIMGI:MGI:95729MousePMID:20570969
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activityFGF2IDAHumanPMID:20011604
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingFGF2IGIUniProtKB:O00329HumanPMID:31915155
Biological ProcessGO:0010863positive regulation of phospholipase C activityFGF2IDAHumanPMID:20011604
Biological ProcessGO:0051897positive regulation of protein kinase B signalingFGF2IDAHumanPMID:26451614
Biological ProcessGO:0051897positive regulation of protein kinase B signalingFGF2IDAHumanPMID:31915155
Biological ProcessGO:0051897positive regulation of protein kinase B signalingFgf2IDAMousePMID:16858399
Biological ProcessGO:0001934positive regulation of protein phosphorylationFgf2IDAMouseMGI:MGI:6414698|PMID:29501879
Biological ProcessGO:0001934positive regulation of protein phosphorylationFgf2IDAMousePMID:15608665
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationFgf2IMPRatPMID:9854551|RGD:8655666
Biological ProcessGO:1903672positive regulation of sprouting angiogenesisFGF2IDAHumanPMID:16756958
Biological ProcessGO:1903672positive regulation of sprouting angiogenesisFGF2IMPHumanPMID:23469107
Biological ProcessGO:2000738positive regulation of stem cell differentiationFgf2IDAMousePMID:15781473
Biological ProcessGO:2000648positive regulation of stem cell proliferationFgf2IDAMousePMID:16141225
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIFGF2IDAHumanPMID:18059339
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIFgf2IGIMGI:MGI:97168MousePMID:8898217
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIFgf2IDAMousePMID:9102311
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIFgf2IDAMousePMID:10391928
Biological ProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationFGF2IGIUniProtKB:Q9ULZ1HumanPMID:23263626
Biological ProcessGO:1905564positive regulation of vascular endothelial cell proliferationFGF2IGIUniProtKB:P11362HumanPMID:23263626
Biological ProcessGO:0043491protein kinase B signalingFgf2IDAMousePMID:16858399
Biological ProcessGO:0051726regulation of cell cycleFgf2IDAMousePMID:9463347
Biological ProcessGO:2000544regulation of endothelial cell chemotaxis to fibroblast growth factorFGF2IDAHumanPMID:16756958
Biological ProcessGO:0046668regulation of retinal cell programmed cell deathFgf2IDAMousePMID:11747369
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolFGF2IDAHumanPMID:20011604
Biological ProcessGO:0048678response to axon injuryFgf2IMPMGI:MGI:1857458MousePMID:16009496
Biological ProcessGO:0048864stem cell developmentFgf2IMPMouseMGI:MGI:2667422|PMID:12843296
Biological ProcessGO:0048863stem cell differentiationFgf2IDAMousePMID:15781473
Biological ProcessGO:0072089stem cell proliferationFgf2IDAMousePMID:16141225
Biological ProcessGO:0072089stem cell proliferationFgf2IGIMGI:MGI:95729MousePMID:20570969
Biological ProcessGO:0021762substantia nigra developmentFgf2IMPMGI:MGI:1857458MousePMID:17234579
Biological ProcessGO:0060129thyroid-stimulating hormone-secreting cell differentiationFgf2IDAMousePMID:9463347
Biological ProcessGO:0006366transcription by RNA polymerase IIFgf2IDAMousePMID:10391928
Biological ProcessGO:0042060wound healingFGF2IDAHumanPMID:16756958
Biological ProcessGO:0042060wound healingFgf2IEPRatPMID:12533868|RGD:2292211

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory