About   Help   FAQ
Fgf2 Gene Detail
Summary
  • Symbol
    Fgf2
  • Name
    fibroblast growth factor 2
  • Synonyms
    bFGF, Fgf-2, Fgfb
  • Feature Type
    protein coding gene
  • IDs
    MGI:95516
    NCBI Gene: 14173
  • Gene Overview
    MyGene.info: FGF2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:37348477-37404893 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 18.41 cM, cytoband A2-B
  • Mapping Data
    17 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95516
protein coding gene Chr3:37348346-37410108 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027170
protein coding gene Chr3:35200284-35258666 (+)
A/J MGP_AJ_G0027130
protein coding gene Chr3:34498821-34555582 (+)
AKR/J MGP_AKRJ_G0027099
protein coding gene Chr3:35137770-35197285 (+)
BALB/cJ MGP_BALBcJ_G0027142
protein coding gene Chr3:34246418-34304886 (+)
C3H/HeJ MGP_C3HHeJ_G0026885
protein coding gene Chr3:35196787-35254674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027588
protein coding gene Chr3:36834723-36897288 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024949
protein coding gene Chr3:32169744-32227451 (+)
CAST/EiJ MGP_CASTEiJ_G0026338
protein coding gene Chr3:35071040-35129322 (+)
CBA/J MGP_CBAJ_G0026862
protein coding gene Chr3:37829169-37896713 (+)
DBA/2J MGP_DBA2J_G0026996
protein coding gene Chr3:33941331-33998282 (+)
FVB/NJ MGP_FVBNJ_G0026964
protein coding gene Chr3:33379459-33438870 (+)
LP/J MGP_LPJ_G0027108
protein coding gene Chr3:35978976-36048086 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026983
protein coding gene Chr3:40296069-40365681 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027647
protein coding gene Chr3:34991845-35053547 (+)
PWK/PhJ MGP_PWKPhJ_G0026071
protein coding gene Chr3:33627173-33689238 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025883
protein coding gene Chr3:34352684-34408526 (+)
WSB/EiJ MGP_WSBEiJ_G0026412
protein coding gene Chr3:35017555-35077291 (+)



Homology
more
  • Human Ortholog
    FGF2, fibroblast growth factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGF2, fibroblast growth factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BFGF, FGF-2, FGFB, HBGF-2
  • Links
    NCBI Gene ID: 2247
    neXtProt AC: NX_P09038
    UniProt: P09038

  • Chr Location
    4q28.1; chr4:122826708-122898235 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 7 alleles in 8 genetic backgrounds
    45 phenotypes from multigenic genotypes
    3 images
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for different null mutations are viable and have some or all of these traits: hypotension, thrombocytosis, impaired wound healing, and reductions in cortical neuronal density, vascular smooth muscle contractility and trabecular bone formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14173 NCBI Gene Model | MGI Sequence Detail 56417 C57BL/6J ±  kb
    transcript NM_008006 RefSeq | MGI Sequence Detail 695 C57BL/6  
    polypeptide P15655 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 4
      cDNA 12
      Primer pair 18
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9761, MGD-MRK-9767, MGD-MRK-9774
    References
    more
    • Summaries
      All 412
      Developmental Gene Expression 113
      Diseases 1
      Gene Ontology 39
      Phenotypes 99
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:269593 Koleini N, et al., Elimination or neutralization of endogenous high-molecular-weight FGF2 mitigates doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H279-H288

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory