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Fgf2
Gene Detail
 Symbol
Name
ID
Fgf2
fibroblast growth factor 2
MGI:95516
STS D3Nds34
Synonyms bFGF, Fgf-2, Fgfb
Feature Type protein coding gene
Genetic Map
Chromosome 3
18.41 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr3:37312519-37405377 bp, + strand
From VEGA annotation of GRCm38

  92859 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1521  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf2

Human
homologs
Human Homolog FGF2, fibroblast growth factor 2 (basic)
NCBI Gene ID 2247
neXtProt AC  NX_P09038
Human Synonyms  BFGF, FGF-2, FGFB, HBGF-2
Human Chr (Location)  4q26; chr4:122826708-122898235 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
 
Homozygotes for different null mutations are viable and have some or all of these traits: hypotension, thrombocytosis, impaired wound healing, and reductions in cortical neuronal density, vascular smooth muscle contractility and trabecular bone formation.
 
Interactions
Fgf2 interacts with 31 markers (Mir17, Mir18b, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process activation of MAPKK activity, angiogenesis, ...
Component cytoplasm, cytosol, ...
Function chemoattractant activity, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (96 records)
Data Summary: Results (337)    Tissues (237)    Images (32)
Theiler Stages: 2, 3, 5, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 161
Northern blot 55
Western blot 3
RT-PCR 114
RNase protection 2
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(4) cDNA(10) Primer pair(17) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007393 (Evidence)
Ensembl Gene ModelENSMUSG00000037225 (Evidence)
Entrez Gene14173 (Evidence)
UniGene473689
DFCITC1654083, TC1679008
DoTSDT.40185420, DT.94041714, DT.94041737, DT.94041743
NIA Mouse Gene IndexU003171
Consensus CDS ProjectCCDS17320.1
International Mouse Knockout Project StatusFgf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007393 VEGA Gene Model | MGI Sequence Detail 92859 C57BL/6J ±  kb
transcript OTTMUST00000017101 VEGA | MGI Sequence Detail 1240 Not Applicable 
polypeptide OTTMUSP00000046776 VEGA | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(5)
Polymorphisms RFLP(4) : SNPs within 2kb(1097 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007489 fibroblast growth factor 2
References (Earliest) J:29477 Abraham JA, et al., Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J. 1986 Oct;5(10):2523-8
(Latest) J:203771 Byun MR, et al., FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression. Bone. 2014 Jan;58:72-80
All references(318)
Other
accession IDs
MGD-MRK-9761, MGD-MRK-9767, MGD-MRK-9774

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory