Fgf2
Gene Detail

Symbol Name ID

Fgf2 fibroblast growth factor 2 MGI:95516

STS

D3Nds34

Synonyms

bFGF, Fgf-2, Fgfb

Feature Type

protein coding gene

Genetic Map

Chromosome 3

18.41 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr3:37312519-37405377 bp, + strand From VEGA annotation of GRCm38   92859 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1521  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf2

Human homologs

Human Homolog		FGF2, fibroblast growth factor 2 (basic)
NCBI Gene ID		2247
neXtProt AC		NX_P09038
Human Synonyms		BFGF, FGF-2, FGFB, HBGF-2
Human Chr (Location)		4q26; chr4:123747863-123819390 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for different null mutations are viable and have some or all of these traits: hypotension, thrombocytosis, impaired wound healing, and reductions in cortical neuronal density, vascular smooth muscle contractility and trabecular bone formation.

 

Gene Ontology (GO) classifications

All GO classifications: (93 annotations)

Process	activation of MAPKK activity, angiogenesis, ...
Component	cytoplasm, cytosol, ...
Function	chemoattractant activity, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (92 records)
Data Summary: Results (290)    Tissues (188)    Images (28)
Theiler Stages: 2, 3, 4, 5, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	112
Northern blot	55
Western blot	3
RT-PCR	116
RNase protection	2

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(4) cDNA(10) Primer pair(17) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007393 (Evidence)
Ensembl Gene Model	ENSMUSG00000037225 (Evidence)
Entrez Gene	14173 (Evidence)
UniGene	473689
DFCI	TC1654083, TC1679008
DoTS	DT.40185420, DT.94041714, DT.94041737, DT.94041743
NIA Mouse Gene Index	U003171
Consensus CDS Project	CCDS17320.1
International Mouse Knockout Project Status	Fgf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007393	VEGA Gene Model | MGI Sequence Detail	92859	C57BL/6J
transcript	OTTMUST00000087561	VEGA | MGI Sequence Detail	754	Not Applicable
polypeptide	OTTMUSP00000047630	VEGA | MGI Sequence Detail	154	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(4) : SNPs(368 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR002209	Heparin-binding growth factor/Fibroblast growth factor
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007489	heparin-binding growth factor 2

References

(Earliest) J:29477 Abraham JA, et al., Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J. 1986 Oct;5(10):2523-8
(Latest) J:193313 Takase HM, et al., FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 2013 Jan 15;27(2):169-81
All references(309)

Other accession IDs

MGD-MRK-9761, MGD-MRK-9767, MGD-MRK-9774