Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTSG
  • Mouse genes Ctsg
  • Rat genes
  • Zfish genes gzm3,gzm3.2,gzm3.3,gzm3.4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctsg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0089720	caspase binding	CTSG	IPI	UniProtKB:P49662	Human	PMID:29077095
Molecular Function	GO:0008201	heparin binding	CTSG	IDA		Human	PMID:11907569
Molecular Function	GO:0008233	peptidase activity	CTSG	IDA		Human	PMID:11907569
Molecular Function	GO:0005515	protein binding	CTSG	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSG	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTSG	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTSG	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ctsg	IPI	PR:O88879	Mouse	PMID:12189154
Molecular Function	GO:0048018	receptor ligand activity	CTSG	IDA		Human	PMID:15210802
Molecular Function	GO:0004252	serine-type endopeptidase activity	CTSG	EXP		Human	PMID:10512690
Molecular Function	GO:0004252	serine-type endopeptidase activity	CTSG	IDA		Human	PMID:12504904
Molecular Function	GO:0004252	serine-type endopeptidase activity	CTSG	IDA		Human	PMID:15100291
Molecular Function	GO:0004252	serine-type endopeptidase activity	CTSG	IDA		Human	PMID:8194606
Molecular Function	GO:0008236	serine-type peptidase activity	CTSG	IMP		Human	PMID:1937776
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSG	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSG	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSG	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSG	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTSG	HDA		Human	PMID:28675934
Cellular Component	GO:0010494	cytoplasmic stress granule	CTSG	IDA		Human	PMID:1937776
Cellular Component	GO:0005829	cytosol	CTSG	IDA		Human	PMID:29077095
Cellular Component	GO:0070062	extracellular exosome	CTSG	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CTSG	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	CTSG	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	CTSG	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	CTSG	IDA		Human	PMID:29077095
Cellular Component	GO:0005615	extracellular space	CTSG	IDA		Human	PMID:32144329
Cellular Component	GO:0005615	extracellular space	CTSG	IDA		Human	PMID:3390156
Cellular Component	GO:0005764	lysosome	CTSG	IDA		Human	PMID:15100291
Cellular Component	GO:0016020	membrane	CTSG	IDA		Human	PMID:29077095
Cellular Component	GO:0005634	nucleus	CTSG	IDA		Human	PMID:11259672
Cellular Component	GO:0005634	nucleus	CTSG	HDA		Human	PMID:21630459
Cellular Component	GO:0005886	plasma membrane	CTSG	IDA		Human	PMID:1861080
Cellular Component	GO:0030141	secretory granule	CTSG	IDA		Human	PMID:11907569
Biological Process	GO:0019731	antibacterial humoral response	CTSG	IDA		Human	PMID:1937776
Biological Process	GO:0098786	biofilm matrix disassembly	CTSG	IDA		Human	PMID:32995850
Biological Process	GO:0071222	cellular response to lipopolysaccharide	CTSG	IDA		Human	PMID:1937776
Biological Process	GO:0050832	defense response to fungus	Ctsg	IGI	MGI:MGI:2679229	Mouse	PMID:10714686
Biological Process	GO:0050832	defense response to fungus	Ctsg	IMP	MGI:MGI:2182170	Mouse	PMID:10714686
Biological Process	GO:0050829	defense response to Gram-negative bacterium	CTSG	IDA		Human	PMID:1937776
Biological Process	GO:0050829	defense response to Gram-negative bacterium	CTSG	IDA		Human	PMID:2116408
Biological Process	GO:0050830	defense response to Gram-positive bacterium	CTSG	IDA		Human	PMID:2116408
Biological Process	GO:0050830	defense response to Gram-positive bacterium	CTSG	IDA		Human	PMID:2117044
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Ctsg	IMP	MGI:MGI:2182170	Mouse	PMID:11907569
Biological Process	GO:0002548	monocyte chemotaxis	CTSG	IDA		Human	PMID:15210802
Biological Process	GO:0050868	negative regulation of T cell activation	CTSG	IDA		Human	PMID:15100291
Biological Process	GO:0042119	neutrophil activation	CTSG	IDA		Human	PMID:22879591
Biological Process	GO:0070946	neutrophil-mediated killing of gram-positive bacterium	Ctsg	IMP	MGI:MGI:2182170	Mouse	PMID:11907569
Biological Process	GO:0030168	platelet activation	CTSG	IDA		Human	PMID:10702240
Biological Process	GO:0050778	positive regulation of immune response	Ctsg	IGI	MGI:MGI:2679229	Mouse	PMID:10714686
Biological Process	GO:0050778	positive regulation of immune response	Ctsg	IMP	MGI:MGI:2182170	Mouse	PMID:10714686
Biological Process	GO:1901731	positive regulation of platelet aggregation	CTSG	IDA		Human	PMID:3390156
Biological Process	GO:0006468	protein phosphorylation	CTSG	IDA		Human	PMID:8573071
Biological Process	GO:0016485	protein processing	CTSG	IDA		Human	PMID:16963625
Biological Process	GO:0016485	protein processing	CTSG	IDA		Human	PMID:22879591
Biological Process	GO:0016485	protein processing	CTSG	IDA		Human	PMID:30804664
Biological Process	GO:0016485	protein processing	CTSG	IDA		Human	PMID:7744748
Biological Process	GO:0006508	proteolysis	CTSG	IDA		Human	PMID:11907569
Biological Process	GO:0006508	proteolysis	CTSG	IDA		Human	PMID:11259672
Biological Process	GO:0006508	proteolysis	CTSG	IDA		Human	PMID:15100291
Biological Process	GO:0006508	proteolysis	CTSG	IDA		Human	PMID:1861080
Biological Process	GO:0006508	proteolysis	CTSG	IDA		Human	PMID:32144329
Biological Process	GO:0032496	response to lipopolysaccharide	Ctsg	IMP	MGI:MGI:2182170	Mouse	PMID:10714686
Biological Process	GO:0032496	response to lipopolysaccharide	Ctsg	IGI	MGI:MGI:2679229	Mouse	PMID:10714686

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern