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Ctsg Gene Detail
Summary
  • Symbol
    Ctsg
  • Name
    cathepsin G
  • Feature Type
    protein coding gene
  • IDs
    MGI:88563
    NCBI Gene: 13035
  • Gene Overview
    MyGene.info: CTSG
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56099885-56102574 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88563
protein coding gene Chr14:56099881-56102574 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021384
protein coding gene Chr14:50175285-50177978 (-)
A/J MGP_AJ_G0021343
protein coding gene Chr14:49179634-49182327 (-)
AKR/J MGP_AKRJ_G0021319
protein coding gene Chr14:50936350-50939043 (-)
BALB/cJ MGP_BALBcJ_G0021346
protein coding gene Chr14:49149837-49152530 (-)
C3H/HeJ MGP_C3HHeJ_G0021127
protein coding gene Chr14:50619798-50622491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021786
protein coding gene Chr14:52698088-52700781 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019328
protein coding gene Chr14:47393134-47395789 (-)
CAST/EiJ MGP_CASTEiJ_G0020646
protein coding gene Chr14:46903200-46905826 (-)
CBA/J MGP_CBAJ_G0021094
protein coding gene Chr14:54241282-54243975 (-)
DBA/2J MGP_DBA2J_G0021214
protein coding gene Chr14:48902457-48905118 (-)
FVB/NJ MGP_FVBNJ_G0021197
protein coding gene Chr14:48317944-48320636 (-)
LP/J MGP_LPJ_G0021289
protein coding gene Chr14:51217915-51220608 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021221
protein coding gene Chr14:53602339-53605031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021812
protein coding gene Chr14:50122910-50125603 (-)
PWK/PhJ MGP_PWKPhJ_G0020390
protein coding gene Chr14:45425859-45428552 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020220
protein coding gene Chr14:46179501-46182188 (-)
WSB/EiJ MGP_WSBEiJ_G0020699
protein coding gene Chr14:50379956-50382648 (-)



Homology
more
  • Human Ortholog
    CTSG, cathepsin G
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CTSG, cathepsin G
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CATG, CG
  • Links
    NCBI Gene ID: 1511
    neXtProt AC: NX_P08311
    UniProt: P08311

  • Chr Location
    14q12; chr14:24573518-24576260 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygous for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13035 NCBI Gene Model | MGI Sequence Detail 2690 C57BL/6J ±  kb
    transcript NM_007800 RefSeq | MGI Sequence Detail 1015 C57BL/6  
    polypeptide P28293 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 7
      cDNA 16
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2247
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 8
      Phenotypes 41
    • Earliest
      J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
    • Latest
      J:245613 Macanas-Pirard P, et al., The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells. PLoS One. 2017;12(1):e0168888

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory