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Ctsg
Gene Detail
 Symbol
Name
ID
Ctsg
cathepsin G
MGI:88563
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr14:56099881-56102574 bp, - strand
From NCBI annotation of GRCm38

  2694 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken

Protein SuperFamily: trypsin
Gene Tree: Ctsg

Human
homologs
Human Homolog CTSG, cathepsin G
NCBI Gene ID 1511
neXtProt AC  NX_P08311
Human Synonyms  CATG, CG
Human Chr (Location)  14q11.2; chr14:24573518-24576260 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygotes for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.
 
Human Diseases Modeled Using Mouse Ctsg (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process defense response to fungus, defense response to Gram-positive bacterium, ...
Component extracellular matrix, extracellular space, ...
Function catalytic activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (1)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 23
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(7) cDNA(15) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000040314 (Evidence)
Entrez Gene13035 (Evidence)
UniGene4858
DFCITC1580917
DoTSDT.530637
NIA Mouse Gene IndexU035600
EC3.4.21.20
Consensus CDS ProjectCCDS27142.1
International Mouse Knockout Project StatusCtsg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13035 NCBI Gene Model | MGI Sequence Detail 2694 C57BL/6J ±  kb
transcript NM_007800 RefSeq | MGI Sequence Detail 1004 Leaden x A1 F1* 
polypeptide P28293 UniProt | EBI | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000006028 cathepsin G
Graphical View of Protein Domain Structure
References (Earliest) J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
(Latest) J:205905 Faraday N, et al., Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS One. 2013;8(8):e71447
All references(67)
Other
accession IDs
MGD-MRK-2247

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory