Ctsg
Gene Detail

Symbol Name ID

Ctsg cathepsin G MGI:88563

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr14:56099881-56102574 bp, - strand From NCBI annotation of GRCm38   2694 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:105646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken

Protein SuperFamily: trypsin
Gene Tree: Ctsg

Human homologs

Human Homolog		CTSG, cathepsin G
NCBI Gene ID		1511
neXtProt AC		NX_P08311
Human Synonyms		CATG, CG
Human Chr (Location)		14q11.2; chr14:25042724-25045466 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygotes for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.

 
Human Diseases Modeled Using Mouse Ctsg (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	defense response to fungus, defense response to Gram-positive bacterium, ...
Component	extracellular matrix, extracellular space, ...
Function	catalytic activity, heparin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (1)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	23

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(7) cDNA(15) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000040314 (Evidence)
Entrez Gene	13035 (Evidence)
UniGene	4858
DFCI	TC1580917
DoTS	DT.530637
NIA Mouse Gene Index	U035600
EC	3.4.21.20
Consensus CDS Project	CCDS27142.1
International Mouse Knockout Project Status	Ctsg

Sequences

Length	Strain/Species
genomic	13035	NCBI Gene Model | MGI Sequence Detail	2694	C57BL/6J
transcript	NM_007800	RefSeq | MGI Sequence Detail	1004	Leaden x A1 F1*
polypeptide	P28293	UniProt | EBI | MGI Sequence Detail	261	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000006028	cathepsin G

Graphical View of Protein Domain Structure

References

(Earliest) J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
(Latest) J:193139 Schoofs T, et al., DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. Blood. 2013 Jan 3;121(1):178-87
All references(61)

Other accession IDs

MGD-MRK-2247