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Ctsg
Gene Detail
Symbol

Name
ID
Ctsg
cathepsin G
MGI:88563
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:56099881-56102574 bp, - strand
From NCBI annotation of GRCm38

  2694 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle

HCOP human homology predictions: CTSG
Protein SuperFamily: trypsin
Gene Tree: Ctsg

Human
homologs
CTSG, cathepsin G
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1511
neXtProt AC: NX_P08311

Human Synonyms: CATG, CG

Human Chr (Location): 14q11.2; chr14:24573518-24576260 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygotes for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Ctsg interacts with 15 markers (Mir208a, Mir208b, Mir465, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process defense response to fungus, defense response to Gram-positive bacterium, ...
Component cytoplasm, extracellular exosome, ...
Function heparin binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (1)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctsg    NEW 
Molecular
reagents
All nucleic(23) Genomic(7) cDNA(15) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000040314 (Evidence)
Entrez Gene 13035 (Evidence)
UniGene 4858
DFCI TC1580917
DoTS DT.530637
NIA Mouse Gene Index U035600
EC 3.4.21.20
Consensus CDS Project CCDS27142.1
International Mouse Phenotyping Consortium Status Ctsg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13035 NCBI Gene Model | MGI Sequence Detail 2694 C57BL/6J ±  kb
transcript NM_007800 RefSeq | MGI Sequence Detail 1004 Leaden x A1 F1* 
polypeptide P28293 UniProt | EBI | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000006028 cathepsin G
Graphical View of Protein Domain Structure
References
(Earliest) J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
(Latest) J:218470 Wang J, et al., Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta. 2014 Nov;1842(11):2174-83
All references(65)
Other
accession IDs
MGD-MRK-2247

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory