Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCND1
  • Mouse genes Ccnd1
  • Rat genes Ccnd1
  • Zfish genes ccnd1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccnd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	CCND1	IDA		Human	PMID:19237565
Molecular Function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	Ccnd1	IDA		Mouse	PMID:12502791
Molecular Function	GO:0019899	enzyme binding	CCND1	IPI	UniProtKB:O75604	Human	PMID:19412162
Molecular Function	GO:0042826	histone deacetylase binding	CCND1	IPI	UniProtKB:O15379	Human	PMID:18417529
Molecular Function	GO:0016301	kinase activity	Ccnd1	IDA		Mouse	PMID:12124778
Molecular Function	GO:0070064	proline-rich region binding	CCND1	IDA		Human	PMID:19124461
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q00534	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:15681588
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:15681588
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:16431923
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P46527	Human	PMID:16431923
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P59595	Human	PMID:16431923
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:O15379	Human	PMID:16461912
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P10275	Human	PMID:16461912
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q01101	Human	PMID:16569215
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q16656	Human	PMID:16864783
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P46527	Human	PMID:17254966
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38398	Human	PMID:17334399
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q00534	Human	PMID:17517622
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q01101	Human	PMID:19124461
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:19237565
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P30285	Human	PMID:19409388
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q5XUX0	Human	PMID:19412162
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:19470470
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:20399237
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P30260	Human	PMID:20439707
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:21242975
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q62796	Human	PMID:21242975
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q96PU4	Human	PMID:21952639
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P24941	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:24218572
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q00534	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:Q96TE0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P24941	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P46527	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P24941	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P46527	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:31217276
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P46527	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:7568034
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:8756624
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:8756624
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P38936	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P46527	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CCND1	IPI	UniProtKB:P24941	Human	PMID:9840943
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:3613334|PMID:16413469
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:3613336|PMID:16413468
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P46414	Mouse	MGI:MGI:76285|PMID:8534916
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:Q8CIG8	Mouse	MGI:MGI:4837754|PMID:20951943
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:4837754|PMID:20951943
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:4439220|PMID:20150892
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:3760191|PMID:17940036
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:3763977|PMID:17948060
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:3654865|PMID:16864783
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P46414	Mouse	MGI:MGI:4820703|PMID:19767775
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:5512954|PMID:19409388
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:5315333|PMID:21242975
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	PR:P39689	Mouse	PMID:12588994
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	MGI:MGI:1351650	Mouse	PMID:21411630
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	PR:O35261	Mouse	PMID:11980909
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	PR:P23611	Mouse	PMID:25331958
Molecular Function	GO:0005515	protein binding	Ccnd1	IPI	PR:P63017	Mouse	PMID:12588994
Molecular Function	GO:0004672	protein kinase activity	Ccnd1	IDA		Mouse	PMID:12588994
Molecular Function	GO:0019901	protein kinase binding	CCND1	IPI	UniProtKB:P11802	Human	PMID:19124461
Molecular Function	GO:0019901	protein kinase binding	CCND1	IPI	UniProtKB:Q00534	Human	PMID:8114739
Molecular Function	GO:0019901	protein kinase binding	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:4820703|PMID:19767775
Molecular Function	GO:0019901	protein kinase binding	Ccnd1	IPI	RGD:621120	Rat	PMID:15809057|RGD:1582338
Molecular Function	GO:0044877	protein-containing complex binding	Ccnd1	IPI	RGD:621120|RGD:69328	Rat	PMID:8651753|RGD:2289148
Molecular Function	GO:0003714	transcription corepressor activity	CCND1	IDA		Human	PMID:16569215
Molecular Function	GO:0003714	transcription corepressor activity	CCND1	IDA		Human	PMID:18417529
Cellular Component	GO:0005923	bicellular tight junction	Ccnd1	IDA		Mouse	PMID:21411630
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	CCND1	IPI		Human	PMID:19237565
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	Ccnd1	IPI		Mouse	MGI:MGI:3763977|PMID:17948060
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CCND1	IDA		Human	PMID:17420273
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CCND1	IDA		Human	PMID:8114739
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Ccnd1	IPI	UniProtKB:P30285	Mouse	MGI:MGI:4820703|PMID:19767775
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Ccnd1	IPI	PR:P30285	Mouse	PMID:12970760
Cellular Component	GO:0005737	cytoplasm	Ccnd1	IDA		Mouse	PMID:21911473
Cellular Component	GO:0005737	cytoplasm	Ccnd1	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005737	cytoplasm	Ccnd1	IDA		Mouse	PMID:19531352
Cellular Component	GO:0005737	cytoplasm	Ccnd1	IDA		Rat	PMID:17962342|RGD:2289135
Cellular Component	GO:0005654	nucleoplasm	CCND1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CCND1	IDA		Human	PMID:11793365
Cellular Component	GO:0005634	nucleus	CCND1	IDA		Human	PMID:20399237
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	MGI:MGI:4820703|PMID:19767775
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:15314168
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:16489008
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:21911473
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:8988060
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:12502791
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:25535395
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005634	nucleus	Ccnd1	IDA		Rat	PMID:17962342|RGD:2289135
Cellular Component	GO:0017053	transcription repressor complex	CCND1	IDA		Human	PMID:16569215
Cellular Component	GO:0017053	transcription repressor complex	CCND1	IDA		Human	PMID:18417529
Biological Process	GO:0031100	animal organ regeneration	Ccnd1	IEP		Rat	PMID:16938172|RGD:2289142
Biological Process	GO:0048593	camera-type eye morphogenesis	ccnd1	IMP	ZFIN:ZDB-MRPHLNO-051201-1	Zfish	PMID:16284195
Biological Process	GO:0008283	cell population proliferation	Ccnd1	IMP	MGI:MGI:1857280	Mouse	PMID:26876175
Biological Process	GO:0071310	cellular response to organic substance	Ccnd1	IDA		Mouse	PMID:18604197
Biological Process	GO:0006974	DNA damage response	CCND1	IDA		Human	PMID:19412162
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Ccnd1	IDA		Mouse	PMID:16176978
Biological Process	GO:0045444	fat cell differentiation	Ccnd1	IDA		Mouse	PMID:12502791
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CCND1	IDA		Human	PMID:19412162
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CCND1	IDA		Human	PMID:33854232
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CCND1	IDA		Human	PMID:33854235
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CCND1	IDA		Human	PMID:33854239
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	Ccnd1	IDA		Mouse	PMID:16176978
Biological Process	GO:0007595	lactation	Ccnd1	IGI	MGI:MGI:99484	Mouse	PMID:11747812
Biological Process	GO:0007595	lactation	Ccnd1	IMP	MGI:MGI:2180640	Mouse	PMID:10419681
Biological Process	GO:0033327	Leydig cell differentiation	Ccnd1	IMP		Rat	PMID:17303663|RGD:2289137
Biological Process	GO:0001889	liver development	Ccnd1	IEP		Rat	PMID:15809057|RGD:1582338
Biological Process	GO:0097421	liver regeneration	Ccnd1	IDA		Mouse	PMID:23740243
Biological Process	GO:0060749	mammary gland alveolus development	Ccnd1	IGI	MGI:MGI:99484	Mouse	PMID:11747812
Biological Process	GO:0060749	mammary gland alveolus development	Ccnd1	IMP	MGI:MGI:2180640	Mouse	PMID:10419681
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Ccnd1	IGI	MGI:MGI:3580016	Mouse	PMID:20075866
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Ccnd1	IGI	MGI:MGI:99484	Mouse	PMID:11747812
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	CCND1	IDA		Human	PMID:19412162
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	Ccnd1	IGI	MGI:MGI:88039	Mouse	PMID:15314168
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ccnd1	IMP	MGI:MGI:1857280	Mouse	PMID:26876175
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CCND1	IDA		Human	PMID:16569215
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CCND1	IDA		Human	PMID:18417529
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ccnd1	IGI	MGI:MGI:88039	Mouse	PMID:15314168
Biological Process	GO:0070050	neuron cellular homeostasis	ccnd1	IMP	ZFIN:ZDB-MRPHLNO-160407-3	Zfish	PMID:26206533
Biological Process	GO:0030182	neuron differentiation	Ccnd1	IMP	MGI:MGI:1857280	Mouse	PMID:26876175
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ccnd1	IMP		Rat	PMID:14604889|RGD:2289294
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	CCND1	IDA		Human	PMID:8114739
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	CCND1	IDA		Human	PMID:19124461
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	Ccnd1	IGI	MGI:MGI:3580016	Mouse	PMID:20075866
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CCND1	IDA		Human	PMID:8114739
Biological Process	GO:0006468	protein phosphorylation	Ccnd1	IDA		Mouse	PMID:12124778
Biological Process	GO:0006468	protein phosphorylation	Ccnd1	IDA		Mouse	PMID:12588994
Biological Process	GO:0000320	re-entry into mitotic cell cycle	Ccnd1	IDA		Mouse	PMID:12502791
Biological Process	GO:0051726	regulation of cell cycle	Ccnd1	IDA		Mouse	PMID:11809706
Biological Process	GO:0051726	regulation of cell cycle	Ccnd1	IDA		Mouse	PMID:12588994
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	Ccnd1	IGI	MGI:MGI:1351650	Mouse	PMID:21411630
Biological Process	GO:0061074	regulation of neural retina development	ccnd1	IGI	ZFIN:ZDB-GENE-020117-1,ZFIN:ZDB-GENE-050417-97	Zfish	PMID:25872183
Biological Process	GO:0051592	response to calcium ion	Ccnd1	IEP		Rat	PMID:7980531|RGD:68221
Biological Process	GO:0051412	response to corticosterone	Ccnd1	IEP		Rat	PMID:12807724|RGD:2289298
Biological Process	GO:0032355	response to estradiol	Ccnd1	IEP		Rat	PMID:17055086|RGD:8694088
Biological Process	GO:0043627	response to estrogen	Ccnd1	IEP		Rat	PMID:17088081|RGD:2289138
Biological Process	GO:0045471	response to ethanol	Ccnd1	IEP		Rat	PMID:17015179|RGD:2289141
Biological Process	GO:0051384	response to glucocorticoid	Ccnd1	IEP		Rat	PMID:16707792|RGD:2289146
Biological Process	GO:0010039	response to iron ion	Ccnd1	IEP		Rat	PMID:16890145|RGD:1582331
Biological Process	GO:0044321	response to leptin	CCND1	IDA		Human	PMID:17344214
Biological Process	GO:0032026	response to magnesium ion	Ccnd1	IEP		Rat	PMID:14566962|RGD:2289295
Biological Process	GO:0014070	response to organic cyclic compound	Ccnd1	IEP		Rat	PMID:17137605|RGD:1625408
Biological Process	GO:0010033	response to organic substance	Ccnd1	IEP		Rat	PMID:16928827|RGD:2289143
Biological Process	GO:0010243	response to organonitrogen compound	Ccnd1	IDA		Rat	PMID:17380078|RGD:2289136
Biological Process	GO:0048545	response to steroid hormone	Ccnd1	IEP		Rat	PMID:15975997|RGD:2289289
Biological Process	GO:0070141	response to UV-A	CCND1	IDA		Human	PMID:18483258
Biological Process	GO:0033197	response to vitamin E	Ccnd1	IEP		Rat	PMID:17015179|RGD:2289141
Biological Process	GO:0010165	response to X-ray	Ccnd1	IEP		Rat	PMID:17148264|RGD:1601086
Biological Process	GO:0009410	response to xenobiotic stimulus	CCND1	IEP		Human	PMID:18291362
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccnd1	IEP		Rat	PMID:12602925|RGD:2289337
Biological Process	GO:0016055	Wnt signaling pathway	Ccnd1	IDA		Mouse	PMID:19056892

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern