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Gene Ontology Browser
Term Detail
GO term:G1/S transition of mitotic cell cycle
GO id:GO:0000082
Definition:The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
Number of paths to term: 16

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-acell cycle G1/S phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of cell cycle G1/S phase transition +
                                                                positively-regulatespositive regulation of cell cycle G1/S phase transition +
                                                                regulatesregulation of cell cycle G1/S phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-amitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-acell cycle G1/S phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of cell cycle G1/S phase transition +
                                                        positively-regulatespositive regulation of cell cycle G1/S phase transition +
                                                        regulatesregulation of cell cycle G1/S phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-amitotic cell cycle process
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-acell cycle G1/S phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of cell cycle G1/S phase transition +
                                                                positively-regulatespositive regulation of cell cycle G1/S phase transition +
                                                                regulatesregulation of cell cycle G1/S phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-acell cycle phase transition
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        part-ofcell cycle process
                                                is-amitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle
                                        is-amitotic cell cycle
                                                part-ofmitotic cell cycle process
                                                        is-amitotic cell cycle phase transition
                                                                is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                        part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                        positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                        regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                        part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                                is-aG2/M transition of mitotic cell cycle +
                                                                is-ametaphase/anaphase transition of mitotic cell cycle +
                                                                negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                                positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                                regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-acell cycle G1/S phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of cell cycle G1/S phase transition +
                                                        positively-regulatespositive regulation of cell cycle G1/S phase transition +
                                                        regulatesregulation of cell cycle G1/S phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-acell cycle phase transition
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell cycle process
                                        is-amitotic cell cycle process
                                                is-amitotic cell cycle phase transition
                                                        is-aG1/S transition of mitotic cell cycle [GO:0000082] (144 genes, 168 annotations)
                                                                part-ofnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                negatively-regulatesnegative regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
                                                                positively-regulatespositive regulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +
                                                                regulatesregulation of G1/S transition of mitotic cell cycle +
                                                                part-ofregulation of transcription involved in G1/S transition of mitotic cell cycle +
                                                        is-aG2/M transition of mitotic cell cycle +
                                                        is-ametaphase/anaphase transition of mitotic cell cycle +
                                                        negatively-regulatesnegative regulation of mitotic cell cycle phase transition +
                                                        positively-regulatespositive regulation of mitotic cell cycle phase transition +
                                                        regulatesregulation of mitotic cell cycle phase transition +


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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory