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Gene Ontology Browser
Term Detail
GO term:tight junction
Synonym: zonula occludens
GO id:GO:0005923
Definition:An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-acell junction
                        is-acell-cell junction
                                is-aapical junction complex
                                        part-ofseptate junction +
                                        part-ofsubapical complex
                                        part-oftight junction [GO:0005923] (110 genes, 131 annotations)
                                                is-ahost-symbiont tight junction
                                        part-ofzonula adherens +

                is-acell junction
                        is-acell-cell junction
                                is-aoccluding junction
                                        is-aseptate junction +
                                        is-atight junction [GO:0005923] (110 genes, 131 annotations)
                                                is-ahost-symbiont tight junction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory