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Term Detail
GO term:transcription corepressor activity
Synonym: transcription co-repressor activity
Synonym: transcription corepressor activity
GO id:GO:0003714
Definition:Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-atranscription factor activity, protein binding
                        is-atranscription factor activity, transcription factor binding
                                is-atranscription cofactor activity
                                        is-aRNA polymerase II transcription cofactor activity +
                                        is-atranscription coactivator activity +
                                        is-atranscription corepressor activity [GO:0003714] (176 genes, 221 annotations)
                                                is-aRNA polymerase II transcription corepressor activity

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
The Jackson Laboratory