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Ccnd1
Gene Detail
Symbol

Name
ID
Ccnd1
cyclin D1
MGI:88313
Synonyms
bcl-1, cD1, CycD1, Cyl-1, PRAD1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:144929931-144939869 bp, - strand
From VEGA annotation of GRCm38

  9939 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCND1
Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccnd1

Human
homologs
CCND1, cyclin D1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 595
neXtProt AC: NX_P24385

Human Synonyms: BCL1, D11S287E, PRAD1, U21B31

Human Chr (Location): 11q13; chr11:69641105-69654474 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CCND1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(10) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted mutations may exhibit reduced body size and viability, impaired retinal development, pregnancy-insensitive mammary glands, and modified development of mammary cancer induced by neu and ras oncogenes, depending on the specific allele or genetic background.
 
Interactions
Ccnd1 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (341 records)
Data Summary: Results (774)    Tissues (367)    Images (191)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 57
RNA in situ 464
Northern blot 57
Western blot 49
RT-PCR 147
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CCND1 ; Xenbase ccnd1 ; ZFIN ccnd1    NEW 
Molecular
reagents
All nucleic(50) Genomic(9) cDNA(26) Primer pair(7) Other(8)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026018 (Evidence)
Ensembl Gene Model ENSMUSG00000070348 (Evidence)
Entrez Gene 12443 (Evidence)
NIA Mouse Gene Index U068737
Consensus CDS Project CCDS22055.1
International Mouse Phenotyping Consortium Status Ccnd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026018 VEGA Gene Model | MGI Sequence Detail 9939 C57BL/6J ±  kb
transcript OTTMUST00000064208 VEGA | MGI Sequence Detail 3740 Not Applicable 
polypeptide OTTMUSP00000031858 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR015451 Cyclin D
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005121 G1/S-specific cyclin-D1
References
(Earliest) J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
(Latest) J:222257 Liu Y, et al., Gpr177-mediated Wnt Signaling Is Required for Secondary Palate Development. J Dent Res. 2015 Jul;94(7):961-7
All references(517)
Other
accession IDs
MGD-MRK-1825, MGI:2141923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory