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Ccnd1
Gene Detail
 Symbol
Name
ID
Ccnd1
cyclin D1
MGI:88313
Synonyms bcl-1, cD1, CycD1, Cyl-1, PRAD1
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:144929931-144939869 bp, - strand
From VEGA annotation of GRCm38

  9939 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccnd1

Human
homologs
Human Homolog CCND1, cyclin D1
NCBI Gene ID 595
neXtProt AC  NX_P24385
Human Synonyms  BCL1, D11S287E, PRAD1, U21B31
Human Chr (Location)  11q13; chr11:69641105-69654474 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CCND1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations may exhibit reduced body size and viability, impaired retinal development, pregnancy-insensitive mammary glands, and modified development of mammary cancer induced by neu and ras oncogenes, depending on the specific allele or genetic background.
 
Interactions
Ccnd1 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process canonical Wnt signaling pathway, cell cycle, ...
Component cyclin-dependent protein kinase holoenzyme complex, cytoplasm, ...
Function cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (309 records)
Data Summary: Results (768)    Tissues (357)    Images (187)
Theiler Stages: 2, 3, 4, 8, 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 51
RNA in situ 464
Northern blot 57
Western blot 49
RT-PCR 147
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(9) cDNA(26) Primer pair(7) Other(8)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026018 (Evidence)
Ensembl Gene ModelENSMUSG00000070348 (Evidence)
Entrez Gene12443 (Evidence)
NIA Mouse Gene IndexU068737
Consensus CDS ProjectCCDS22055.1
International Mouse Knockout Project StatusCcnd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026018 VEGA Gene Model | MGI Sequence Detail 9939 C57BL/6J ±  kb
transcript OTTMUST00000064208 VEGA | MGI Sequence Detail 3740 Not Applicable 
polypeptide OTTMUSP00000031858 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014400 Cyclin A/B/D/E
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR015451 Cyclin D
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005121 G1/S-specific cyclin-D1
References (Earliest) J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
(Latest) J:209138 Nobs L, et al., Stage-specific requirement for cyclin D1 in glial progenitor cells of the cerebral cortex. Glia. 2014 May;62(5):829-39
All references(482)
Other
accession IDs
MGD-MRK-1825, MGI:2141923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory