Ccnd1
Gene Detail

Symbol Name ID

Ccnd1 cyclin D1 MGI:88313

Synonyms

bcl-1, cD1, CycD1, Cyl-1, PRAD1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr7:144929931-144939869 bp, - strand From VEGA annotation of GRCm38   9939 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccnd1

Human homologs

Human Homolog		CCND1, cyclin D1
NCBI Gene ID		595
neXtProt AC		NX_P24385
Human Synonyms		BCL1, D11S287E, PRAD1, U21B31
Human Chr (Location)		11q13; chr11:69455873-69469242 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CCND1

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygotes for targeted mutations may exhibit reduced body size and viability, impaired retinal development, pregnancy-insensitive mammary glands, and modified development of mammary cancer induced by neu and ras oncogenes, depending on the specific allele or genetic background.

 

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	canonical Wnt receptor signaling pathway, cell cycle, ...
Component	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, ...
Function	cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (277 records)
Data Summary: Results (733)    Tissues (341)    Images (184)
Theiler Stages: 2, 3, 5, 8, 9, 10, 11, 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	51
RNA in situ	431
Northern blot	57
Western blot	49
RT-PCR	145

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(9) cDNA(26) Primer pair(6) Other(8)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000026018 (Evidence)
Ensembl Gene Model	ENSMUSG00000070348 (Evidence)
Entrez Gene	12443 (Evidence)
NIA Mouse Gene Index	U068737
Consensus CDS Project	CCDS22055.1
International Mouse Knockout Project Status	Ccnd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026018	VEGA Gene Model | MGI Sequence Detail	9939	C57BL/6J
transcript	OTTMUST00000064208	VEGA | MGI Sequence Detail	3740	Not Applicable
polypeptide	OTTMUSP00000031858	VEGA | MGI Sequence Detail	295	Not Applicable

All sequences(36) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014400	Cyclin A/B/D/E
InterPro	IPR004367	Cyclin, C-terminal
InterPro	IPR013763	Cyclin-like
InterPro	IPR006671	Cyclin, N-terminal
Protein Ontology	PR:000005121	G1/S-specific cyclin-D1

References

(Earliest) J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(440)

Other accession IDs

MGD-MRK-1825, MGI:2141923