Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACNA1C
  • Mouse genes Cacna1c
  • Rat genes Cacna1c
  • Zfish genes cacna1c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacna1c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	CACNA1C	IPI	UniProtKB:P35609	Human	PMID:17110593
Molecular Function	GO:0005516	calmodulin binding	CACNA1C	IPI	UniProtKB:P0DP23	Human	PMID:15140941
Molecular Function	GO:0005516	calmodulin binding	CACNA1C	IPI	UniProtKB:P0DP24	Human	PMID:15140941
Molecular Function	GO:0005516	calmodulin binding	CACNA1C	IPI	UniProtKB:P0DP25	Human	PMID:15140941
Molecular Function	GO:0019899	enzyme binding	Cacna1c	IPI	UniProtKB:B1AWC9|UniProtKB:Q01063	Mouse	MGI:MGI:5286798|PMID:21670503
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	CACNA1C	IDA		Human	PMID:15454078
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	Cacna1c	IDA		Rat	PMID:17068255|RGD:7205477
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:Q86UR5	Human	PMID:11438518
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:Q9NZU7	Human	PMID:15140941
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:P54284	Human	PMID:18535142
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:Q02641-1	Human	PMID:18535142
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:Q08289-1	Human	PMID:18535142
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:P12814	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	CACNA1C	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:P51637	Mouse	MGI:MGI:6189492|PMID:24952909
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:P51637	Mouse	MGI:MGI:3628972|PMID:16648270
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:Q9Z0F4	Mouse	MGI:MGI:4821678|PMID:20639889
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	PR:E9Q401	Mouse	PMID:16352659
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	PR:Q8CC27	Mouse	PMID:16787652
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:O88751	Rat	PMID:15140941|RGD:7207149
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:P54287	Rat	PMID:15170217|RGD:11558004
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:Q9WUD9	Rat	PMID:16352297|RGD:8553251
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:Q92905	Rat	PMID:16483597|RGD:1580158
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	RGD:620385	Rat	PMID:17224447|RGD:7207146
Molecular Function	GO:0005515	protein binding	Cacna1c	IPI	UniProtKB:P63329	Rat	PMID:19478199|RGD:8553443
Molecular Function	GO:0019904	protein domain specific binding	Cacna1c	IPI	RGD:1303071	Rat	PMID:14569017|RGD:1304018
Molecular Function	GO:0051721	protein phosphatase 2A binding	Cacna1c	IPI	RGD:3380	Rat	PMID:16519540|RGD:1582610
Molecular Function	GO:0051721	protein phosphatase 2A binding	Cacna1c	IPI	RGD:3381	Rat	PMID:16519540|RGD:1582610
Molecular Function	GO:0031369	translation initiation factor binding	Cacna1c	IPI	RGD:9273439	Rat	PMID:23737983|RGD:10755504
Molecular Function	GO:0044325	transmembrane transporter binding	Cacna1c	IPI	UniProtKB:P11716	Rat	PMID:11576544|RGD:8553445
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA1C	IDA		Human	PMID:12130699
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA1C	IMP		Human	PMID:24728418
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA1C	IDA		Human	PMID:8392192
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IDA		Mouse	PMID:7635187
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IMP	MGI:MGI:2674114	Mouse	PMID:16251435
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IDA		Mouse	PMID:1385406
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IDA		Mouse	PMID:16267232
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IMP	MGI:MGI:3047071	Mouse	PMID:15504730
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IMP	MGI:MGI:2176227,MGI:MGI:2674119	Mouse	PMID:12881419
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IMP	MGI:MGI:2389040,MGI:MGI:2674119	Mouse	PMID:14609949
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IMP		Rat	PMID:16483597|RGD:1580158
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1c	IDA		Rat	PMID:16554304|RGD:1582591
Molecular Function	GO:0005245	voltage-gated calcium channel activity	cacna1c	IMP	ZFIN:ZDB-GENO-070213-2	Zfish	PMID:11702785
Molecular Function	GO:0005245	voltage-gated calcium channel activity	cacna1c	IDA		Zfish	PMID:23549079
Molecular Function	GO:0005245	voltage-gated calcium channel activity	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-130802-1,ZFIN:ZDB-MRPHLNO-130807-1	Zfish	PMID:23549079
Molecular Function	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential	CACNA1C	IMP		Human	PMID:26253506
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C	IMP		Human	PMID:17224476
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C	IMP		Human	PMID:15454078
Molecular Function	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	Cacna1c	IDA		Mouse	PMID:32109384
Molecular Function	GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Cacna1c	IMP		Mouse	MGI:MGI:5822987|PMID:18045623
Cellular Component	GO:0030424	axon	Cacna1c	IDA		Rat	PMID:22473424|RGD:10411906
Cellular Component	GO:0002095	caveolar macromolecular signaling complex	Cacna1c	IDA		Mouse	PMID:16648270
Cellular Component	GO:0009986	cell surface	Cacna1c	IDA		Rat	PMID:21822937|RGD:13782265
Cellular Component	GO:0005737	cytoplasm	CACNA1C	IDA		Human	PMID:11206130
Cellular Component	GO:0030425	dendrite	Cacna1c	IDA		Rat	PMID:15140941|RGD:7207149
Cellular Component	GO:0030425	dendrite	Cacna1c	IDA		Rat	PMID:17224447|RGD:7207146
Cellular Component	GO:0043198	dendritic shaft	Cacna1c	IDA		Mouse	PMID:15090038
Cellular Component	GO:0098978	glutamatergic synapse	Cacna1c	IDA		Rat	PMID:18067152|RGD:12050119
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	CACNA1C	IDA		Human	PMID:15454078
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	Cacna1c	IDA		Rat	PMID:15170217|RGD:11558004
Cellular Component	GO:0016020	membrane	CACNA1C	IDA		Human	PMID:8392192
Cellular Component	GO:0016020	membrane	Cacna1c	IDA		Mouse	PMID:15132976
Cellular Component	GO:0016020	membrane	Cacna1c	IDA		Rat	PMID:16519540|RGD:1582610
Cellular Component	GO:0043025	neuronal cell body	Cacna1c	IDA		Mouse	PMID:15090038
Cellular Component	GO:0043025	neuronal cell body	Cacna1c	IDA		Rat	PMID:15140941|RGD:7207149
Cellular Component	GO:0043025	neuronal cell body	Cacna1c	IDA		Rat	PMID:17224447|RGD:7207146
Cellular Component	GO:0005886	plasma membrane	CACNA1C	IDA		Human	PMID:11206130
Cellular Component	GO:0005886	plasma membrane	Cacna1c	IDA		Mouse	PMID:15090038
Cellular Component	GO:0005886	plasma membrane	Cacna1c	IDA		Mouse	PMID:7598723
Cellular Component	GO:0005886	plasma membrane	Cacna1c	IDA		Rat	PMID:17068255|RGD:7205477
Cellular Component	GO:0014069	postsynaptic density	CACNA1C	IDA		Human	PMID:14140941
Cellular Component	GO:0014069	postsynaptic density	Cacna1c	IDA		Rat	PMID:15140941|RGD:7207149
Cellular Component	GO:0045211	postsynaptic membrane	Cacna1c	IDA		Rat	PMID:18067152|RGD:12050119
Cellular Component	GO:0042734	presynaptic membrane	Cacna1c	IDA		Rat	PMID:18067152|RGD:12050119
Cellular Component	GO:0032991	protein-containing complex	Cacna1c	IDA		Rat	PMID:17068255|RGD:7205477
Cellular Component	GO:0032991	protein-containing complex	Cacna1c	IDA		Rat	PMID:17224447|RGD:7207146
Cellular Component	GO:0042383	sarcolemma	Cacna1c	IDA		Rat	PMID:16483597|RGD:1580158
Cellular Component	GO:0042383	sarcolemma	Cacna1c	IDA		Rat	PMID:21474431|RGD:7175530
Cellular Component	GO:0030315	T-tubule	Cacna1c	IDA		Mouse	PMID:22355118
Cellular Component	GO:0030315	T-tubule	Cacna1c	IDA		Rat	PMID:14569017|RGD:1304018
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNA1C	IDA		Human	PMID:12130699
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNA1C	IDA		Human	PMID:17224476
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna1c	IMP		Mouse	PMID:3315915
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna1c	IMP	MGI:MGI:2674119	Mouse	PMID:12881419
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna1c	IDA		Rat	PMID:16554304|RGD:1582591
Cellular Component	GO:0030018	Z disc	Cacna1c	IDA		Mouse	PMID:19383796
Cellular Component	GO:0030018	Z disc	Cacna1c	IDA		Rat	PMID:15980179|RGD:1600288
Cellular Component	GO:0030018	Z disc	Cacna1c	IDA		Rat	PMID:11053140|RGD:8554533
Biological Process	GO:0007628	adult walking behavior	Cacna1c	IGI	MGI:MGI:109482	Mouse	PMID:9882694
Biological Process	GO:0061564	axon development	Cacna1c	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0070509	calcium ion import	Cacna1c	IMP		Rat	PMID:19422800|RGD:7205456
Biological Process	GO:0070509	calcium ion import	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-130802-1,ZFIN:ZDB-MRPHLNO-130807-1	Zfish	PMID:23549079
Biological Process	GO:0098703	calcium ion import across plasma membrane	Cacna1c	IDA		Mouse	PMID:32109384
Biological Process	GO:0070588	calcium ion transmembrane transport	CACNA1C	IDA		Human	PMID:15454078
Biological Process	GO:0070588	calcium ion transmembrane transport	CACNA1C	IMP		Human	PMID:24728418
Biological Process	GO:0070588	calcium ion transmembrane transport	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-130802-1,ZFIN:ZDB-MRPHLNO-130807-1	Zfish	PMID:23549079|ZFIN:ZDB-PUB-130412-15
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C	IDA		Human	PMID:15454078
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C	IMP		Human	PMID:30023270
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C	IMP		Human	PMID:30172029
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C	IMP		Human	PMID:30513141
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C	IMP		Human	PMID:34163037
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	Cacna1c	IDA		Rat	PMID:15170217|RGD:11558004
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	Cacna1c	IMP		Rat	PMID:18562674|RGD:152177517
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	Cacna1c	IDA		Rat	PMID:27905406|RGD:152985537
Biological Process	GO:0006816	calcium ion transport	Cacna1c	IMP	MGI:MGI:2674119	Mouse	PMID:15132976
Biological Process	GO:0006816	calcium ion transport	Cacna1c	IDA		Mouse	PMID:7635187
Biological Process	GO:0006816	calcium ion transport	Cacna1c	IMP	MGI:MGI:2674114	Mouse	PMID:16251435
Biological Process	GO:0006816	calcium ion transport	Cacna1c	IMP		Rat	PMID:16483597|RGD:1580158
Biological Process	GO:0006816	calcium ion transport	cacna1c	IMP	ZFIN:ZDB-GENO-070213-2	Zfish	PMID:11702785
Biological Process	GO:0017156	calcium-ion regulated exocytosis	Cacna1c	IMP	MGI:MGI:2176227,MGI:MGI:2674119	Mouse	PMID:12881419
Biological Process	GO:0043010	camera-type eye development	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0061337	cardiac conduction	CACNA1C	IMP		Human	PMID:24728418
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0086065	cell communication involved in cardiac conduction	Cacna1c	IDA		Mouse	PMID:32109384
Biological Process	GO:1904646	cellular response to amyloid-beta	Cacna1c	IEP		Rat	PMID:21822937|RGD:13782265
Biological Process	GO:0021987	cerebral cortex development	Cacna1c	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0007268	chemical synaptic transmission	Cacna1c	IMP	MGI:MGI:2674114	Mouse	PMID:16251435
Biological Process	GO:0022038	corpus callosum development	Cacna1c	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-130802-1,ZFIN:ZDB-MRPHLNO-130807-1	Zfish	PMID:23549079
Biological Process	GO:0035115	embryonic forelimb morphogenesis	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0051649	establishment of localization in cell	Cacna1c	IMP	MGI:MGI:2674119	Mouse	PMID:15132976
Biological Process	GO:0051649	establishment of localization in cell	Cacna1c	IMP	MGI:MGI:2176227,MGI:MGI:2674119	Mouse	PMID:12881419
Biological Process	GO:0051649	establishment of localization in cell	Cacna1c	IDA		Mouse	PMID:32109384
Biological Process	GO:0006887	exocytosis	Cacna1c	IMP		Rat	PMID:18562674|RGD:152177517
Biological Process	GO:0042593	glucose homeostasis	Cacna1c	IMP	MGI:MGI:2176227,MGI:MGI:2674119	Mouse	PMID:12881419
Biological Process	GO:0030252	growth hormone secretion	Cacna1c	IDA		Mouse	PMID:1385406
Biological Process	GO:0007507	heart development	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0001947	heart looping	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-141113-1	Zfish	PMID:24700505
Biological Process	GO:0003007	heart morphogenesis	cacna1c	IMP	ZFIN:ZDB-GENO-070213-2	Zfish	PMID:11702785
Biological Process	GO:0003007	heart morphogenesis	cacna1c	IMP	ZFIN:ZDB-GENO-070213-1	Zfish	PMID:11702785
Biological Process	GO:0002520	immune system development	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0030073	insulin secretion	Cacna1c	IMP	MGI:MGI:2176227,MGI:MGI:2674119	Mouse	PMID:12881419
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Cacna1c	IMP	MGI:MGI:2674119	Mouse	PMID:15132976
Biological Process	GO:0001822	kidney development	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-141113-1	Zfish	PMID:24700505
Biological Process	GO:0098912	membrane depolarization during atrial cardiac muscle cell action potential	CACNA1C	IMP		Human	PMID:17224476
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	CACNA1C	IMP		Human	PMID:26253506
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0021554	optic nerve development	Cacna1c	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0003301	physiological cardiac muscle hypertrophy	cacna1c	IMP	ZFIN:ZDB-MRPHLNO-130802-1	Zfish	PMID:25536179
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Cacna1c	IDA		Mouse	MGI:MGI:6243790|PMID:24086669
Biological Process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Cacna1c	IMP		Rat	PMID:25675390|RGD:13782366
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	CACNA1C	IDA		Human	PMID:12130699
Biological Process	GO:0032024	positive regulation of insulin secretion	Cacna1c	IMP		Rat	PMID:18562674|RGD:152177517
Biological Process	GO:1904181	positive regulation of membrane depolarization	Cacna1c	IMP		Rat	PMID:18562674|RGD:152177517
Biological Process	GO:0008217	regulation of blood pressure	Cacna1c	IMP	MGI:MGI:2389040,MGI:MGI:2674119	Mouse	PMID:14609949
Biological Process	GO:0008016	regulation of heart contraction	cacna1c	IMP	ZFIN:ZDB-GENO-070213-1	Zfish	PMID:11702785
Biological Process	GO:0008016	regulation of heart contraction	cacna1c	IMP	ZFIN:ZDB-GENO-070213-2	Zfish	PMID:11702785
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNA1C	IMP		Human	PMID:15863612
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNA1C	IMP		Human	PMID:17224476
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNA1C	IMP		Human	PMID:26253506
Biological Process	GO:0046620	regulation of organ growth	Cacna1c	IMP	MGI:MGI:2674119	Mouse	PMID:15132976
Biological Process	GO:0019229	regulation of vasoconstriction	Cacna1c	IMP	MGI:MGI:2389040,MGI:MGI:2674119	Mouse	PMID:14609949
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	CACNA1C	IMP		Human	PMID:15454078
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	CACNA1C	IMP		Human	PMID:26253506
Biological Process	GO:0097305	response to alcohol	Cacna1c	IEP		Rat	PMID:27905406|RGD:152985537
Biological Process	GO:0031667	response to nutrient levels	Cacna1c	IEP		Rat	PMID:20873977|RGD:152985538
Biological Process	GO:0014070	response to organic cyclic compound	Cacna1c	IDA		Rat	PMID:27905406|RGD:152985537
Biological Process	GO:0006939	smooth muscle contraction	Cacna1c	IMP	MGI:MGI:2389040,MGI:MGI:2674119	Mouse	PMID:16636102
Biological Process	GO:0060083	smooth muscle contraction involved in micturition	Cacna1c	IMP	MGI:MGI:2674119	Mouse	PMID:15132976
Biological Process	GO:0008542	visual learning	Cacna1c	IMP	MGI:MGI:2674114	Mouse	PMID:16251435

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern