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Gene Ontology Browser
Term Detail
GO term:exocytosis
Synonym: nonselective vesicle exocytosis
Synonym: vesicle exocytosis
GO id:GO:0006887
Alternate id: GO:0016195, GO:0016194
Definition:A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells.
Number of paths to term: 8

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aacetylcholine secretion +
                                        is-aaspartate secretion +
                                        is-acatecholamine secretion +
                                        is-acontractile vacuole discharge
                                        is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                is-aconstitutive secretory pathway +
                                                is-aexosomal secretion +
                                                negatively-regulatesnegative regulation of exocytosis +
                                                is-aplatelet degranulation +
                                                positively-regulatespositive regulation of exocytosis +
                                                is-aregulated exocytosis +
                                                regulatesregulation of exocytosis +
                                                part-ofvesicle docking involved in exocytosis +
                                                part-ofvesicle fusion to plasma membrane +
                                                part-ofvesicle tethering involved in exocytosis
                                        is-aextracellular matrix constituent secretion +
                                        is-aglutamate secretion +
                                        is-aglutamine secretion
                                        is-aglycine secretion +
                                        negatively-regulatesnegative regulation of secretion by cell +
                                        is-aoctopamine secretion +
                                        positively-regulatespositive regulation of secretion by cell +
                                        is-aprimary amine secretion +
                                        is-aprotein secretion +
                                        regulatesregulation of secretion by cell +
                                        is-asecretion by lung epithelial cell involved in lung growth
                                        is-asecretion by the type IV secretion system +
                                        is-aserotonin secretion +
                                        is-asignal release +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-acellular localization
                                part-ofestablishment of localization in cell
                                        is-asecretion by cell
                                                is-aacetylcholine secretion +
                                                is-aaspartate secretion +
                                                is-acatecholamine secretion +
                                                is-acontractile vacuole discharge
                                                is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                        is-aconstitutive secretory pathway +
                                                        is-aexosomal secretion +
                                                        negatively-regulatesnegative regulation of exocytosis +
                                                        is-aplatelet degranulation +
                                                        positively-regulatespositive regulation of exocytosis +
                                                        is-aregulated exocytosis +
                                                        regulatesregulation of exocytosis +
                                                        part-ofvesicle docking involved in exocytosis +
                                                        part-ofvesicle fusion to plasma membrane +
                                                        part-ofvesicle tethering involved in exocytosis
                                                is-aextracellular matrix constituent secretion +
                                                is-aglutamate secretion +
                                                is-aglutamine secretion
                                                is-aglycine secretion +
                                                negatively-regulatesnegative regulation of secretion by cell +
                                                is-aoctopamine secretion +
                                                positively-regulatespositive regulation of secretion by cell +
                                                is-aprimary amine secretion +
                                                is-aprotein secretion +
                                                regulatesregulation of secretion by cell +
                                                is-asecretion by lung epithelial cell involved in lung growth
                                                is-asecretion by the type IV secretion system +
                                                is-aserotonin secretion +
                                                is-asignal release +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-aestablishment of localization in cell
                                        is-asecretion by cell
                                                is-aacetylcholine secretion +
                                                is-aaspartate secretion +
                                                is-acatecholamine secretion +
                                                is-acontractile vacuole discharge
                                                is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                        is-aconstitutive secretory pathway +
                                                        is-aexosomal secretion +
                                                        negatively-regulatesnegative regulation of exocytosis +
                                                        is-aplatelet degranulation +
                                                        positively-regulatespositive regulation of exocytosis +
                                                        is-aregulated exocytosis +
                                                        regulatesregulation of exocytosis +
                                                        part-ofvesicle docking involved in exocytosis +
                                                        part-ofvesicle fusion to plasma membrane +
                                                        part-ofvesicle tethering involved in exocytosis
                                                is-aextracellular matrix constituent secretion +
                                                is-aglutamate secretion +
                                                is-aglutamine secretion
                                                is-aglycine secretion +
                                                negatively-regulatesnegative regulation of secretion by cell +
                                                is-aoctopamine secretion +
                                                positively-regulatespositive regulation of secretion by cell +
                                                is-aprimary amine secretion +
                                                is-aprotein secretion +
                                                regulatesregulation of secretion by cell +
                                                is-asecretion by lung epithelial cell involved in lung growth
                                                is-asecretion by the type IV secretion system +
                                                is-aserotonin secretion +
                                                is-asignal release +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-asingle-organism transport
                                                is-asecretion
                                                        is-asecretion by cell
                                                                is-aacetylcholine secretion +
                                                                is-aaspartate secretion +
                                                                is-acatecholamine secretion +
                                                                is-acontractile vacuole discharge
                                                                is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                                        is-aconstitutive secretory pathway +
                                                                        is-aexosomal secretion +
                                                                        negatively-regulatesnegative regulation of exocytosis +
                                                                        is-aplatelet degranulation +
                                                                        positively-regulatespositive regulation of exocytosis +
                                                                        is-aregulated exocytosis +
                                                                        regulatesregulation of exocytosis +
                                                                        part-ofvesicle docking involved in exocytosis +
                                                                        part-ofvesicle fusion to plasma membrane +
                                                                        part-ofvesicle tethering involved in exocytosis
                                                                is-aextracellular matrix constituent secretion +
                                                                is-aglutamate secretion +
                                                                is-aglutamine secretion
                                                                is-aglycine secretion +
                                                                negatively-regulatesnegative regulation of secretion by cell +
                                                                is-aoctopamine secretion +
                                                                positively-regulatespositive regulation of secretion by cell +
                                                                is-aprimary amine secretion +
                                                                is-aprotein secretion +
                                                                regulatesregulation of secretion by cell +
                                                                is-asecretion by lung epithelial cell involved in lung growth
                                                                is-asecretion by the type IV secretion system +
                                                                is-aserotonin secretion +
                                                                is-asignal release +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-avesicle-mediated transport
                                                part-ofcargo loading into vesicle +
                                                is-acontractile vacuole discharge
                                                is-aearly endosome to late endosome transport +
                                                is-aearly endosome to recycling endosome transport +
                                                is-aendocytic import into cell
                                                is-aendocytic recycling +
                                                is-aendocytosis +
                                                is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                        is-aconstitutive secretory pathway +
                                                        is-aexosomal secretion +
                                                        negatively-regulatesnegative regulation of exocytosis +
                                                        is-aplatelet degranulation +
                                                        positively-regulatespositive regulation of exocytosis +
                                                        is-aregulated exocytosis +
                                                        regulatesregulation of exocytosis +
                                                        part-ofvesicle docking involved in exocytosis +
                                                        part-ofvesicle fusion to plasma membrane +
                                                        part-ofvesicle tethering involved in exocytosis
                                                is-aGolgi vesicle transport +
                                                part-ofmembrane budding +
                                                is-amultivesicular body sorting pathway
                                                is-aplasma membrane to endosome transport
                                                regulatesregulation of vesicle-mediated transport +
                                                is-aretrograde transport, endosome to Golgi +
                                                is-aretrograde transport, endosome to plasma membrane
                                                is-aretrograde transport, plasma membrane to Golgi
                                                part-ofSNARE complex disassembly +
                                                is-asynaptic vesicle budding from endosome
                                                is-asynaptic vesicle to endosome fusion +
                                                is-asynaptic vesicle transport +
                                                is-atranscytosis +
                                                part-ofvesicle docking +
                                                part-ofvesicle fusion +
                                                part-ofvesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +
                                                part-ofvesicle fusion with Golgi cis cisterna membrane +
                                                part-ofvesicle targeting +
                                                part-ofvesicle uncoating +
                                                is-avesicle-mediated cholesterol transport +
                                                is-avesicle-mediated transport involved in floral organ abscission +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aacetylcholine secretion +
                                                        is-aaspartate secretion +
                                                        is-acatecholamine secretion +
                                                        is-acontractile vacuole discharge
                                                        is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                                is-aconstitutive secretory pathway +
                                                                is-aexosomal secretion +
                                                                negatively-regulatesnegative regulation of exocytosis +
                                                                is-aplatelet degranulation +
                                                                positively-regulatespositive regulation of exocytosis +
                                                                is-aregulated exocytosis +
                                                                regulatesregulation of exocytosis +
                                                                part-ofvesicle docking involved in exocytosis +
                                                                part-ofvesicle fusion to plasma membrane +
                                                                part-ofvesicle tethering involved in exocytosis
                                                        is-aextracellular matrix constituent secretion +
                                                        is-aglutamate secretion +
                                                        is-aglutamine secretion
                                                        is-aglycine secretion +
                                                        negatively-regulatesnegative regulation of secretion by cell +
                                                        is-aoctopamine secretion +
                                                        positively-regulatespositive regulation of secretion by cell +
                                                        is-aprimary amine secretion +
                                                        is-aprotein secretion +
                                                        regulatesregulation of secretion by cell +
                                                        is-asecretion by lung epithelial cell involved in lung growth
                                                        is-asecretion by the type IV secretion system +
                                                        is-aserotonin secretion +
                                                        is-asignal release +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aacetylcholine secretion +
                                        is-aaspartate secretion +
                                        is-acatecholamine secretion +
                                        is-acontractile vacuole discharge
                                        is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                is-aconstitutive secretory pathway +
                                                is-aexosomal secretion +
                                                negatively-regulatesnegative regulation of exocytosis +
                                                is-aplatelet degranulation +
                                                positively-regulatespositive regulation of exocytosis +
                                                is-aregulated exocytosis +
                                                regulatesregulation of exocytosis +
                                                part-ofvesicle docking involved in exocytosis +
                                                part-ofvesicle fusion to plasma membrane +
                                                part-ofvesicle tethering involved in exocytosis
                                        is-aextracellular matrix constituent secretion +
                                        is-aglutamate secretion +
                                        is-aglutamine secretion
                                        is-aglycine secretion +
                                        negatively-regulatesnegative regulation of secretion by cell +
                                        is-aoctopamine secretion +
                                        positively-regulatespositive regulation of secretion by cell +
                                        is-aprimary amine secretion +
                                        is-aprotein secretion +
                                        regulatesregulation of secretion by cell +
                                        is-asecretion by lung epithelial cell involved in lung growth
                                        is-asecretion by the type IV secretion system +
                                        is-aserotonin secretion +
                                        is-asignal release +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aacetylcholine secretion +
                                                        is-aaspartate secretion +
                                                        is-acatecholamine secretion +
                                                        is-acontractile vacuole discharge
                                                        is-aexocytosis [GO:0006887] (296 genes, 480 annotations)
                                                                is-aconstitutive secretory pathway +
                                                                is-aexosomal secretion +
                                                                negatively-regulatesnegative regulation of exocytosis +
                                                                is-aplatelet degranulation +
                                                                positively-regulatespositive regulation of exocytosis +
                                                                is-aregulated exocytosis +
                                                                regulatesregulation of exocytosis +
                                                                part-ofvesicle docking involved in exocytosis +
                                                                part-ofvesicle fusion to plasma membrane +
                                                                part-ofvesicle tethering involved in exocytosis
                                                        is-aextracellular matrix constituent secretion +
                                                        is-aglutamate secretion +
                                                        is-aglutamine secretion
                                                        is-aglycine secretion +
                                                        negatively-regulatesnegative regulation of secretion by cell +
                                                        is-aoctopamine secretion +
                                                        positively-regulatespositive regulation of secretion by cell +
                                                        is-aprimary amine secretion +
                                                        is-aprotein secretion +
                                                        regulatesregulation of secretion by cell +
                                                        is-asecretion by lung epithelial cell involved in lung growth
                                                        is-asecretion by the type IV secretion system +
                                                        is-aserotonin secretion +
                                                        is-asignal release +


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory