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Gene Ontology Browser
Term Detail
GO term:calcium ion regulated exocytosis
Synonym: calcium ion-dependent exocytosis
GO id:GO:0017156
Definition:The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
CommentsNote that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-aregulated exocytosis
                                                        is-acalcium ion regulated exocytosis [GO:0017156] (101 genes, 206 annotations)
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-acalcium ion regulated lysosome exocytosis
                                                                is-acortical granule exocytosis +
                                                                is-adense core granule exocytosis +
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-asynaptic vesicle exocytosis +
                                                                is-azymogen granule exocytosis
                                                        is-aleukocyte degranulation +
                                                        negatively-regulatesnegative regulation of regulated secretory pathway +
                                                        is-aplatelet degranulation +
                                                        positively-regulatespositive regulation of regulated secretory pathway +
                                                        regulatesregulation of regulated secretory pathway +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-asingle-organism transport
                                                is-asecretion
                                                        is-asecretion by cell
                                                                is-aexocytosis
                                                                        is-aregulated exocytosis
                                                                                is-acalcium ion regulated exocytosis [GO:0017156] (101 genes, 206 annotations)
                                                                                        is-aacrosomal vesicle exocytosis +
                                                                                        is-acalcium ion regulated lysosome exocytosis
                                                                                        is-acortical granule exocytosis +
                                                                                        is-adense core granule exocytosis +
                                                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                                                        is-asynaptic vesicle exocytosis +
                                                                                        is-azymogen granule exocytosis
                                                                                is-aleukocyte degranulation +
                                                                                negatively-regulatesnegative regulation of regulated secretory pathway +
                                                                                is-aplatelet degranulation +
                                                                                positively-regulatespositive regulation of regulated secretory pathway +
                                                                                regulatesregulation of regulated secretory pathway +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-aestablishment of localization
                                is-atransport
                                        is-avesicle-mediated transport
                                                is-aexocytosis
                                                        is-aregulated exocytosis
                                                                is-acalcium ion regulated exocytosis [GO:0017156] (101 genes, 206 annotations)
                                                                        is-aacrosomal vesicle exocytosis +
                                                                        is-acalcium ion regulated lysosome exocytosis
                                                                        is-acortical granule exocytosis +
                                                                        is-adense core granule exocytosis +
                                                                        negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                        positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                        regulatesregulation of calcium ion-dependent exocytosis +
                                                                        is-asynaptic vesicle exocytosis +
                                                                        is-azymogen granule exocytosis
                                                                is-aleukocyte degranulation +
                                                                negatively-regulatesnegative regulation of regulated secretory pathway +
                                                                is-aplatelet degranulation +
                                                                positively-regulatespositive regulation of regulated secretory pathway +
                                                                regulatesregulation of regulated secretory pathway +


obsolete Gene_Ontology
        is-abiological_process
                is-alocalization
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aexocytosis
                                                                is-aregulated exocytosis
                                                                        is-acalcium ion regulated exocytosis [GO:0017156] (101 genes, 206 annotations)
                                                                                is-aacrosomal vesicle exocytosis +
                                                                                is-acalcium ion regulated lysosome exocytosis
                                                                                is-acortical granule exocytosis +
                                                                                is-adense core granule exocytosis +
                                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                                is-asynaptic vesicle exocytosis +
                                                                                is-azymogen granule exocytosis
                                                                        is-aleukocyte degranulation +
                                                                        negatively-regulatesnegative regulation of regulated secretory pathway +
                                                                        is-aplatelet degranulation +
                                                                        positively-regulatespositive regulation of regulated secretory pathway +
                                                                        regulatesregulation of regulated secretory pathway +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asecretion by cell
                                        is-aexocytosis
                                                is-aregulated exocytosis
                                                        is-acalcium ion regulated exocytosis [GO:0017156] (101 genes, 206 annotations)
                                                                is-aacrosomal vesicle exocytosis +
                                                                is-acalcium ion regulated lysosome exocytosis
                                                                is-acortical granule exocytosis +
                                                                is-adense core granule exocytosis +
                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                is-asynaptic vesicle exocytosis +
                                                                is-azymogen granule exocytosis
                                                        is-aleukocyte degranulation +
                                                        negatively-regulatesnegative regulation of regulated secretory pathway +
                                                        is-aplatelet degranulation +
                                                        positively-regulatespositive regulation of regulated secretory pathway +
                                                        regulatesregulation of regulated secretory pathway +


obsolete Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism localization
                                is-asingle-organism transport
                                        is-asecretion
                                                is-asecretion by cell
                                                        is-aexocytosis
                                                                is-aregulated exocytosis
                                                                        is-acalcium ion regulated exocytosis [GO:0017156] (101 genes, 206 annotations)
                                                                                is-aacrosomal vesicle exocytosis +
                                                                                is-acalcium ion regulated lysosome exocytosis
                                                                                is-acortical granule exocytosis +
                                                                                is-adense core granule exocytosis +
                                                                                negatively-regulatesnegative regulation of calcium ion-dependent exocytosis +
                                                                                positively-regulatespositive regulation of calcium ion-dependent exocytosis +
                                                                                regulatesregulation of calcium ion-dependent exocytosis +
                                                                                is-asynaptic vesicle exocytosis +
                                                                                is-azymogen granule exocytosis
                                                                        is-aleukocyte degranulation +
                                                                        negatively-regulatesnegative regulation of regulated secretory pathway +
                                                                        is-aplatelet degranulation +
                                                                        positively-regulatespositive regulation of regulated secretory pathway +
                                                                        regulatesregulation of regulated secretory pathway +


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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory