Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRAF
  • Mouse genes Braf
  • Rat genes Braf
  • Zfish genes braf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Braf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	BRAF	IDA		Human	PMID:18567582
Molecular Function	GO:0042802	identical protein binding	BRAF	IPI	UniProtKB:P15056	Human	PMID:16858395
Molecular Function	GO:0042802	identical protein binding	BRAF	IPI	UniProtKB:P15056	Human	PMID:19727074
Molecular Function	GO:0042802	identical protein binding	BRAF	IPI	UniProtKB:P15056	Human	PMID:22169110
Molecular Function	GO:0042802	identical protein binding	BRAF	IPI	UniProtKB:P15056	Human	PMID:22510884
Molecular Function	GO:0042802	identical protein binding	BRAF	IPI	UniProtKB:P15056	Human	PMID:25155755
Molecular Function	GO:0042802	identical protein binding	BRAF	IPI	UniProtKB:P15056	Human	PMID:25437913
Molecular Function	GO:0004708	MAP kinase kinase activity	BRAF	IMP		Human	PMID:29433126
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Braf	IDA		Rat	PMID:10648842|RGD:2298801
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	Braf	IMP		Rat	PMID:16508002|RGD:1580106
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Braf	IMP		Rat	PMID:16508002|RGD:1580106
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P31946	Human	PMID:12620389
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P31947	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02156	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q13233	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q15349	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q13233	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q8CGE9	Human	PMID:17380122
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P46940	Human	PMID:17563371
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P08238	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:17979178
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P46940	Human	PMID:18567582
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:20130576
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:20141835
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P29678	Human	PMID:21441910
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01111	Human	PMID:21478863
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02156	Human	PMID:21625473
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:22169110
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:22510884
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q61097	Human	PMID:22510884
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q99N57	Human	PMID:22510884
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q13114	Human	PMID:23153539
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:23680146
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:23934108
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:23934108
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P31946	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01112	Human	PMID:24441586
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:24746704
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:25155755
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:25155755
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:25437913
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507	Human	PMID:25600339
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:25600339
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01112	Human	PMID:26165597
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:26466569
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q8TF40	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q9P278	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01112	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507|UniProtKB:Q02750|UniProtKB:Q6VAB6	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q8IVT5	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01111	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01112	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:31024343
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P04049	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P31946	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P31947	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P01111	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P31946	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P36507	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:P63104	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	BRAF	IPI	UniProtKB:Q02750	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Braf	IPI	UniProtKB:Q99N57	Mouse	MGI:MGI:4457468|PMID:20141835
Molecular Function	GO:0005515	protein binding	Braf	IPI	UniProtKB:Q61097	Mouse	MGI:MGI:6355580|PMID:21441104
Molecular Function	GO:0005515	protein binding	Braf	IPI	UniProtKB:Q99N57	Mouse	MGI:MGI:5317969|PMID:22169110
Molecular Function	GO:0005515	protein binding	Braf	IPI	UniProtKB:P01111	Mouse	MGI:MGI:5927440|PMID:21478863
Molecular Function	GO:0005515	protein binding	Braf	IPI	PR:Q3U2C5	Mouse	PMID:22628551
Molecular Function	GO:0005515	protein binding	Braf	IPI	PR:Q61337	Mouse	PMID:16116448
Molecular Function	GO:0005515	protein binding	Braf	IPI	PR:P31750	Mouse	PMID:16116448
Molecular Function	GO:0005515	protein binding	Braf	IPI	PR:Q60739	Mouse	PMID:16116448
Molecular Function	GO:0005515	protein binding	Braf	IPI	RGD:621840	Rat	PMID:15150271|RGD:1580097
Molecular Function	GO:0004672	protein kinase activity	BRAF	IDA		Human	PMID:17563371
Molecular Function	GO:0004672	protein kinase activity	Braf	IDA		Mouse	MGI:MGI:5430891|PMID:17563371
Molecular Function	GO:0004674	protein serine/threonine kinase activity	BRAF	IDA		Human	PMID:18567582
Molecular Function	GO:0004674	protein serine/threonine kinase activity	BRAF	IDA		Human	PMID:19667065
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Braf	IDA		Rat	PMID:15150271|RGD:1580097
Molecular Function	GO:0044877	protein-containing complex binding	Braf	IPI	RGD:737237|RGD:2827|RGD:70495	Rat	PMID:15917294|RGD:2292643
Molecular Function	GO:0044877	protein-containing complex binding	Braf	IPI	RGD:3531	Rat	PMID:16508002|RGD:1580106
Molecular Function	GO:0097110	scaffold protein binding	BRAF	IPI	UniProtKB:P46940	Human	PMID:18567582
Molecular Function	GO:0031267	small GTPase binding	Braf	IDA		Rat	PMID:12138204|RGD:11567269
Cellular Component	GO:0044297	cell body	Braf	IDA		Mouse	PMID:16980614
Cellular Component	GO:0005737	cytoplasm	Braf	IDA		Mouse	PMID:15736129
Cellular Component	GO:0005829	cytosol	BRAF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	BRAF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Braf	IDA		Rat	PMID:10336669|RGD:2315873
Cellular Component	GO:0005739	mitochondrion	Braf	IDA		Mouse	PMID:16116448
Cellular Component	GO:0043005	neuron projection	Braf	IDA		Mouse	PMID:16980614
Cellular Component	GO:0043005	neuron projection	Braf	IDA		Rat	PMID:10336669|RGD:2315873
Cellular Component	GO:0005634	nucleus	Braf	IDA		Rat	PMID:10336669|RGD:2315873
Cellular Component	GO:0005886	plasma membrane	Braf	IDA		Mouse	PMID:15736129
Cellular Component	GO:0005886	plasma membrane	Braf	IDA		Rat	PMID:12138204|RGD:11567269
Biological Process	GO:0046632	alpha-beta T cell differentiation	Braf	IMP	MGI:MGI:3711006	Mouse	PMID:23334952
Biological Process	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:18228248
Biological Process	GO:0043367	CD4-positive, alpha-beta T cell differentiation	Braf	IMP	MGI:MGI:3711006	Mouse	PMID:23334952
Biological Process	GO:0030154	cell differentiation	Braf	IGI	MGI:MGI:97847	Mouse	PMID:10704835
Biological Process	GO:0071277	cellular response to calcium ion	BRAF	IDA		Human	PMID:18567582
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Braf	IEP		Rat	PMID:12138204|RGD:11567269
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Braf	IDA		Mouse	PMID:22628551
Biological Process	GO:0072577	endothelial cell apoptotic process	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:9207797
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	BRAF	IDA		Human	PMID:18567582
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:15784729
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Braf	IMP		Mouse	PMID:23616533
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:3620008,MGI:MGI:3622450	Mouse	PMID:16342120
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:3711006	Mouse	PMID:23334952
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0090150	establishment of protein localization to membrane	BRAF	IDA		Human	PMID:23010278
Biological Process	GO:0060324	face development	Braf	IGI	MGI:MGI:97847	Mouse	PMID:18952847
Biological Process	GO:0060323	head morphogenesis	Braf	IMP		Mouse	PMID:24733831
Biological Process	GO:0060291	long-term synaptic potentiation	Braf	IMP	MGI:MGI:3620008,MGI:MGI:3622450	Mouse	PMID:16342120
Biological Process	GO:0000165	MAPK cascade	BRAF	IDA		Human	PMID:18567582
Biological Process	GO:0000165	MAPK cascade	BRAF	IDA		Human	PMID:29433126
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:15784729
Biological Process	GO:0043066	negative regulation of apoptotic process	BRAF	IDA		Human	PMID:19667065
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:9207797
Biological Process	GO:0010764	negative regulation of fibroblast migration	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:16980614
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Braf	IMP		Rat	PMID:18194435|RGD:2315872
Biological Process	GO:2000301	negative regulation of synaptic vesicle exocytosis	Braf	IMP		Mouse	PMID:23616533
Biological Process	GO:0048680	positive regulation of axon regeneration	Braf	IDA		Mouse	PMID:24733831
Biological Process	GO:0050772	positive regulation of axonogenesis	Braf	IGI	MGI:MGI:1346866	Mouse	PMID:24733831
Biological Process	GO:0050772	positive regulation of axonogenesis	Braf	IMP		Mouse	PMID:24733831
Biological Process	GO:0050772	positive regulation of axonogenesis	Braf	IGI	MGI:MGI:1346867	Mouse	PMID:24733831
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	BRAF	IDA		Human	PMID:22065586
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:18228248
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:15784729
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP		Mouse	PMID:23616533
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:3620008,MGI:MGI:3622450	Mouse	PMID:16342120
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP	MGI:MGI:3711006	Mouse	PMID:23334952
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IDA		Mouse	PMID:22892241
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Braf	IMP		Rat	PMID:19720729|RGD:2315869
Biological Process	GO:0010628	positive regulation of gene expression	BRAF	IMP		Human	PMID:22065586
Biological Process	GO:0010628	positive regulation of gene expression	Braf	IGI	MGI:MGI:97321	Mouse	PMID:24733831
Biological Process	GO:0010828	positive regulation of glucose transmembrane transport	BRAF	IDA		Human	PMID:23010278
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	BRAF	IDA		Human	PMID:19667065
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Braf	IGI	MGI:MGI:104572	Mouse	PMID:15199148
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0043368	positive T cell selection	Braf	IMP	MGI:MGI:3711006	Mouse	PMID:23334952
Biological Process	GO:0006468	protein phosphorylation	BRAF	IDA		Human	PMID:17563371
Biological Process	GO:0006468	protein phosphorylation	Braf	IDA		Mouse	MGI:MGI:5430891|PMID:17563371
Biological Process	GO:0006468	protein phosphorylation	Braf	IDA		Rat	PMID:10648842|RGD:2298801
Biological Process	GO:0006468	protein phosphorylation	Braf	IDA		Rat	PMID:15150271|RGD:1580097
Biological Process	GO:0006468	protein phosphorylation	Braf	IMP		Rat	PMID:16508002|RGD:1580106
Biological Process	GO:0048679	regulation of axon regeneration	Braf	IGI	MGI:MGI:1346867	Mouse	PMID:24733831
Biological Process	GO:0048679	regulation of axon regeneration	Braf	IGI	MGI:MGI:1346866	Mouse	PMID:24733831
Biological Process	GO:0042127	regulation of cell population proliferation	Braf	IGI	MGI:MGI:103038	Mouse	PMID:22891351
Biological Process	GO:0045580	regulation of T cell differentiation	Braf	IMP	MGI:MGI:1857579	Mouse	PMID:18228248
Biological Process	GO:0051591	response to cAMP	Braf	IMP		Rat	PMID:19720729|RGD:2315869
Biological Process	GO:0043434	response to peptide hormone	Braf	IMP		Rat	PMID:19720729|RGD:2315869
Biological Process	GO:0035019	somatic stem cell population maintenance	Braf	IGI	MGI:MGI:97847	Mouse	PMID:23022482
Biological Process	GO:0043149	stress fiber assembly	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Braf	IMP		Mouse	PMID:15199148
Biological Process	GO:0016079	synaptic vesicle exocytosis	Braf	IMP		Mouse	PMID:23616533
Biological Process	GO:0033077	T cell differentiation in thymus	Braf	IMP	MGI:MGI:3711006	Mouse	PMID:23334952
Biological Process	GO:0050852	T cell receptor signaling pathway	Braf	IDA		Mouse	PMID:18228248
Biological Process	GO:0048538	thymus development	Braf	IGI	MGI:MGI:97847	Mouse	PMID:18952847
Biological Process	GO:0030878	thyroid gland development	Braf	IGI	MGI:MGI:97847	Mouse	PMID:18952847
Biological Process	GO:0070413	trehalose metabolism in response to stress	BRAF	IMP		Human	PMID:9837904
Biological Process	GO:0008542	visual learning	Braf	IMP	MGI:MGI:3620008,MGI:MGI:3622450	Mouse	PMID:16342120

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern