Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AURKA
  • Mouse genes Aurka
  • Rat genes Aurka
  • Zfish genes aurka
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aurka

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035175	histone H3S10 kinase activity	Aurka	IMP		Mouse	PMID:21274965
Molecular Function	GO:0140677	molecular function activator activity	AURKA	EXP		Human	PMID:12237287
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9NWT8	Human	PMID:12244051
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:14580337
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q15398	Human	PMID:15987997
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9UBN7	Human	PMID:17604723
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q8IXJ6	Human	PMID:17726514
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:O14920	Human	PMID:17939994
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q96R06	Human	PMID:18361916
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q6PGQ7	Human	PMID:18521620
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P53350	Human	PMID:18615013
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:18662907
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:A2APB8	Human	PMID:18663142
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P04198	Human	PMID:19111882
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:O15392	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9NQS7	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9NQS7-1	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:19357306
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:19801554
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P24522	Human	PMID:20460379
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9H7T9	Human	PMID:20596670
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q8TCI5	Human	PMID:20643351
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9D9W1	Human	PMID:20643351
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q00839	Human	PMID:21242313
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P61978	Human	PMID:21821029
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q8VDQ8	Human	PMID:22014574
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:22110403
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P23468	Human	PMID:22305495
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q5BJ29	Human	PMID:22306998
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:O15350	Human	PMID:22340593
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:O94889	Human	PMID:23213400
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q13618	Human	PMID:23213400
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P00533	Human	PMID:23520446
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P04198	Human	PMID:23792191
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q14247,UniProtKB:Q14511	Human	PMID:24574519
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P06748	Human	PMID:24857377
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q13123	Human	PMID:24996188
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P04198	Human	PMID:25175806
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q00839	Human	PMID:25986610
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P04198	Human	PMID:27728805
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:P04198	Human	PMID:27837025
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:27837025
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9H334	Human	PMID:28218735
Molecular Function	GO:0005515	protein binding	AURKA	IPI	UniProtKB:Q9ULW0	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Aurka	IPI	UniProtKB:Q810L3	Mouse	MGI:MGI:3575445|PMID:15793587
Molecular Function	GO:0005515	protein binding	Aurka	IPI	PR:Q02956	Mouse	PMID:19668197
Molecular Function	GO:0005515	protein binding	Aurka	IPI	PR:A2APB8	Mouse	PMID:19668197
Molecular Function	GO:0046982	protein heterodimerization activity	AURKA	IPI	UniProtKB:P24522	Human	PMID:20460379
Molecular Function	GO:0004672	protein kinase activity	AURKA	IDA		Human	PMID:14580337
Molecular Function	GO:0004672	protein kinase activity	AURKA	IDA		Human	PMID:19801554
Molecular Function	GO:0004672	protein kinase activity	AURKA	IDA		Human	PMID:21600873
Molecular Function	GO:0004672	protein kinase activity	Aurka	IDA		Mouse	PMID:9245792
Molecular Function	GO:0019901	protein kinase binding	AURKA	IPI	UniProtKB:P53350	Human	PMID:18615013
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKA	EXP		Human	PMID:13678582
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKA	EXP		Human	PMID:18566290
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKA	EXP		Human	PMID:21807936
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AURKA	IMP		Human	PMID:28218735
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Aurka	IDA		Rat	PMID:12124350|RGD:619665
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Aurka	IPI	PR:Q810L3	Mouse	PMID:15793587
Cellular Component	GO:0043203	axon hillock	Aurka	IDA		Mouse	PMID:19668197
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	PMID:17726514
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	PMID:21399614
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	PMID:21600873
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	PMID:23213400
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	PMID:25657325
Cellular Component	GO:0005813	centrosome	AURKA	IDA		Human	PMID:30538148
Cellular Component	GO:0005813	centrosome	Aurka	IDA		Mouse	PMID:9245792
Cellular Component	GO:0005813	centrosome	Aurka	IDA		Rat	PMID:12124350|RGD:619665
Cellular Component	GO:0036064	ciliary basal body	AURKA	IDA		Human	PMID:17604723
Cellular Component	GO:0005829	cytosol	AURKA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042585	germinal vesicle	Aurka	IDA		Mouse	PMID:14695913
Cellular Component	GO:0098978	glutamatergic synapse	Aurka	IDA		Mouse	PMID:11980711
Cellular Component	GO:0098978	glutamatergic synapse	Aurka	IEP		Mouse	PMID:11980711
Cellular Component	GO:0072687	meiotic spindle	Aurka	IDA		Mouse	PMID:14695913
Cellular Component	GO:0015630	microtubule cytoskeleton	AURKA	IDA		Human	PMID:19801554
Cellular Component	GO:0005815	microtubule organizing center	Aurka	IDA		Mouse	MGI:MGI:6867120|PMID:27753540
Cellular Component	GO:0005815	microtubule organizing center	Aurka	IGI	MGI:MGI:97602	Mouse	PMID:19668197
Cellular Component	GO:0005815	microtubule organizing center	Aurka	IGI	MGI:MGI:1932915	Mouse	PMID:19668197
Cellular Component	GO:0072686	mitotic spindle	AURKA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	Aurka	IDA		Mouse	PMID:9245792
Cellular Component	GO:0097431	mitotic spindle pole	AURKA	IDA		Human	PMID:25657325
Cellular Component	GO:0005654	nucleoplasm	AURKA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	AURKA	IDA		Human	PMID:20531406
Cellular Component	GO:0048471	perinuclear region of cytoplasm	AURKA	IDA		Human	PMID:20531406
Cellular Component	GO:0014069	postsynaptic density	Aurka	IEP		Mouse	PMID:11980711
Cellular Component	GO:0014069	postsynaptic density	Aurka	IDA		Mouse	PMID:11980711
Cellular Component	GO:0045120	pronucleus	Aurka	IDA		Mouse	PMID:14695913
Cellular Component	GO:0005819	spindle	Aurka	IDA		Rat	PMID:12124350|RGD:619665
Cellular Component	GO:0005876	spindle microtubule	AURKA	IDA		Human	PMID:19801554
Cellular Component	GO:0000922	spindle pole	Aurka	IDA		Mouse	MGI:MGI:6867120|PMID:27753540
Cellular Component	GO:0031616	spindle pole centrosome	AURKA	IDA		Human	PMID:19801554
Biological Process	GO:0009948	anterior/posterior axis specification	Aurka	IMP	MGI:MGI:3836420	Mouse	PMID:22939930
Biological Process	GO:0006915	apoptotic process	Aurka	IMP	MGI:MGI:3836420	Mouse	PMID:22939930
Biological Process	GO:0007098	centrosome cycle	Aurka	IGI	MGI:MGI:1932915	Mouse	PMID:17060449
Biological Process	GO:0051642	centrosome localization	Aurka	IMP		Mouse	PMID:22832491
Biological Process	GO:0061523	cilium disassembly	AURKA	IMP		Human	PMID:17604723
Biological Process	GO:0097421	liver regeneration	AURKA	IDA		Human	PMID:19435814
Biological Process	GO:0051321	meiotic cell cycle	Aurka	IMP		Mouse	PMID:21274965
Biological Process	GO:0000212	meiotic spindle organization	Aurka	IMP		Mouse	PMID:14695913
Biological Process	GO:0000226	microtubule cytoskeleton organization	Aurka	IGI	MGI:MGI:1932915	Mouse	PMID:19668197
Biological Process	GO:0000226	microtubule cytoskeleton organization	Aurka	IGI	MGI:MGI:97602	Mouse	PMID:19668197
Biological Process	GO:0000278	mitotic cell cycle	Aurka	IMP		Mouse	PMID:22832491
Biological Process	GO:0000278	mitotic cell cycle	Aurka	IMP		Mouse	PMID:15793587
Biological Process	GO:0000278	mitotic cell cycle	aurka	IMP	ZFIN:ZDB-MRPHLNO-130522-1	Zfish	PMID:23351126
Biological Process	GO:0007100	mitotic centrosome separation	Aurka	IMP	MGI:MGI:3836423	Mouse	PMID:19075002
Biological Process	GO:0007100	mitotic centrosome separation	Aurka	IGI	MGI:MGI:1932915	Mouse	PMID:17060449
Biological Process	GO:0007052	mitotic spindle organization	Aurka	IMP	MGI:MGI:3826513	Mouse	PMID:18801727
Biological Process	GO:0007052	mitotic spindle organization	Aurka	IMP	MGI:MGI:5498678	Mouse	PMID:18345035
Biological Process	GO:0043066	negative regulation of apoptotic process	Aurka	IMP	MGI:MGI:3836420	Mouse	PMID:22939930
Biological Process	GO:0010629	negative regulation of gene expression	AURKA	IMP		Human	PMID:28218735
Biological Process	GO:0032091	negative regulation of protein binding	AURKA	IDA		Human	PMID:21820309
Biological Process	GO:0090233	negative regulation of spindle checkpoint	Aurka	IMP	MGI:MGI:3836423	Mouse	PMID:19075002
Biological Process	GO:1990138	neuron projection extension	Aurka	IGI	MGI:MGI:97602	Mouse	PMID:19668197
Biological Process	GO:1990138	neuron projection extension	Aurka	IGI	MGI:MGI:1919369	Mouse	PMID:19668197
Biological Process	GO:1990138	neuron projection extension	Aurka	IGI	MGI:MGI:1932915	Mouse	PMID:19668197
Biological Process	GO:0018105	peptidyl-serine phosphorylation	AURKA	IMP		Human	PMID:28218735
Biological Process	GO:0090141	positive regulation of mitochondrial fission	AURKA	IMP		Human	PMID:21822277
Biological Process	GO:1900195	positive regulation of oocyte maturation	Aurka	IMP		Mouse	PMID:14695913
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Aurka	IMP		Mouse	PMID:17060449
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Aurka	IMP		Mouse	PMID:17060449
Biological Process	GO:0071539	protein localization to centrosome	Aurka	IMP		Mouse	PMID:17060449
Biological Process	GO:0006468	protein phosphorylation	AURKA	IDA		Human	PMID:21600873
Biological Process	GO:0006468	protein phosphorylation	AURKA	IDA		Human	PMID:21820309
Biological Process	GO:0006468	protein phosphorylation	Aurka	IGI	MGI:MGI:101765	Mouse	PMID:17060449
Biological Process	GO:0006468	protein phosphorylation	Aurka	IDA		Rat	PMID:12124350|RGD:619665
Biological Process	GO:0031647	regulation of protein stability	AURKA	IMP		Human	PMID:15987997
Biological Process	GO:0032355	response to estradiol	Aurka	IEP		Rat	PMID:15601761|RGD:1643347
Biological Process	GO:0009611	response to wounding	AURKA	IDA		Human	PMID:19435814
Biological Process	GO:0007057	spindle assembly involved in female meiosis I	Aurka	IMP		Mouse	PMID:21274965
Biological Process	GO:0007051	spindle organization	AURKA	IMP		Human	PMID:21820309

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern