Aurka
Gene Detail

Symbol Name ID

Aurka aurora kinase A MGI:894678

Synonyms

AIRK1, Ark1, aurora A, Aurora-A, Ayk1, IAK, IAK1, Stk6

Feature Type

protein coding gene

Genetic Map

Chromosome 2

94.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr2:172356190-172370535 bp, - strand From VEGA annotation of GRCm38   14346 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurka

Human homologs

Human Homolog		AURKA, aurora kinase A
NCBI Gene ID		6790
neXtProt AC		NX_O14965
Human Synonyms		AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7
Human Chr (Location)		20q13; chr20:54944445-54967351 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AURKA

Alleles and phenotypes

All alleles(25) : Targeted(4) Gene trapped(21)
 

Mice homozygous for a null allele display embryonic lethality before implantation, early embryonic growth arrest, and impaired mitosis. Heterozygous null mice display increased incidence of tumors primarily lymphomas and chromosomal instability.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cell cycle, cell division, ...
Component	centrosome, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (84)    Tissues (21)    Images (50)
Theiler Stages: 5, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	75
RT-PCR	8

cDNA source data(142)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(146) cDNA(143) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016161 (Evidence)
Ensembl Gene Model	ENSMUSG00000027496 (Evidence)
Entrez Gene	20878 (Evidence)
UniGene	249363
DFCI	TC1572434, TC1589536
DoTS	DT.101376812, DT.534821, DT.94234089
NIA Mouse Gene Index	U023718
EC	2.7.11.1
PDB	3D2I, 3D2K, 3DAJ, 3D14, 3D15, 3DJ5, 3DJ6, 3DJ7
Consensus CDS Project	CCDS17129.1
International Mouse Knockout Project Status	Aurka

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016161	VEGA Gene Model | MGI Sequence Detail	14346	C57BL/6J
transcript	OTTMUST00000038659	VEGA | MGI Sequence Detail	1862	Not Applicable
polypeptide	OTTMUSP00000017293	VEGA | MGI Sequence Detail	395	Not Applicable

All sequences(43) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(118 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000004515	aurora kinase A

References

(Earliest) J:5970 Ferguson JM, et al., A new type of chondrodystrophic mutant in the mouse. J Med Genet. 1978 Apr;15(2):128-31
(Latest) J:190555 Yoon Y, et al., Conditional Aurora A deficiency differentially affects early mouse embryo patterning. Dev Biol. 2012 Nov 1;371(1):77-85
All references(60)

Other accession IDs

MGI:2139176, MGI:2139368