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Aurka
Gene Detail
 Symbol
Name
ID
Aurka
aurora kinase A
MGI:894678
Synonyms AIRK1, Ark1, aurora A, Aurora-A, Ayk1, IAK, IAK1, Stk6
Feature Type protein coding gene
Genetic Map
Chromosome 2
94.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:172356190-172370535 bp, - strand
From VEGA annotation of GRCm38

  14346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurka

Human
homologs
Human Homolog AURKA, aurora kinase A
NCBI Gene ID 6790
neXtProt AC  NX_O14965
Human Synonyms  AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7
Human Chr (Location)  20q13; chr20:56369389-56392454 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(21) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality before implantation, early embryonic growth arrest, and impaired mitosis. Heterozygous null mice display increased incidence of tumors primarily lymphomas and chromosomal instability.
 
Interactions
Aurka interacts with 121 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process anterior/posterior axis specification, cell cycle, ...
Component axon hillock, centrosome, ...
Function ATP binding, histone serine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (84)    Tissues (21)    Images (50)
Theiler Stages: 4, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 75
RT-PCR 8
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(23) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016161 (Evidence)
Ensembl Gene ModelENSMUSG00000027496 (Evidence)
Entrez Gene20878 (Evidence)
DFCITC1572434, TC1589536, TC1661441, TC1773859
DoTSDT.101376812, DT.110708525, DT.534821, DT.94234089
NIA Mouse Gene IndexU023718
EC2.7.11.1
PDB3D2I, 3D2K, 3DAJ, 3D14, 3D15, 3DJ5, 3DJ6, 3DJ7
Consensus CDS ProjectCCDS17129.1, CCDS71204.1
International Mouse Knockout Project StatusAurka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016161 VEGA Gene Model | MGI Sequence Detail 14346 C57BL/6J ±  kb
transcript OTTMUST00000038659 VEGA | MGI Sequence Detail 1862 Not Applicable 
polypeptide OTTMUSP00000017293 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004515 aurora kinase A
References (Earliest) J:5970 Ferguson JM, et al., A new type of chondrodystrophic mutant in the mouse. J Med Genet. 1978 Apr;15(2):128-31
(Latest) J:206964 Wu X, et al., A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior. J Neurosci. 2014 Jan 22;34(4):1510-22
All references(68)
Other
accession IDs
MGI:2139176, MGI:2139368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory