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Aurka
Gene Detail
Symbol

Name
ID
Aurka
aurora kinase A
MGI:894678
Synonyms
AIRK1, Ark1, aurora A, Aurora-A, Ayk1, IAK, IAK1, Stk6
Feature Type
protein coding gene
Genetic Map
Chromosome 2
94.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:172356190-172370535 bp, - strand
From VEGA annotation of GRCm38

  14346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AURKA
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Aurka

Human
homologs
AURKA, aurora kinase A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6790
neXtProt AC: NX_O14965

Human Synonyms: AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7

Human Chr (Location): 20q13; chr20:56369389-56392295 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(21) Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality before implantation, early embryonic growth arrest, and impaired mitosis. Heterozygous null mice display increased incidence of tumors primarily lymphomas and chromosomal instability.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Aurka interacts with 121 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process anterior/posterior axis specification, cell cycle, ...
Component axon hillock, centrosome, ...
Function ATP binding, histone serine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (84)    Tissues (22)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 75
RT-PCR 8
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aurka    NEW 
Molecular
reagents
All nucleic(26) cDNA(23) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016161 (Evidence)
Ensembl Gene Model ENSMUSG00000027496 (Evidence)
Entrez Gene 20878 (Evidence)
DFCI TC1572434, TC1589536, TC1661441, TC1773859
DoTS DT.101376812, DT.110708525, DT.534821, DT.94234089
NIA Mouse Gene Index U023718
EC 2.7.11.1
PDB 3D14, 3D15, 3D2I, 3D2K, 3DAJ, 3DJ5, 3DJ6, 3DJ7
Consensus CDS Project CCDS17129.1, CCDS71204.1
International Mouse Phenotyping Consortium Status Aurka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016161 VEGA Gene Model | MGI Sequence Detail 14346 C57BL/6J ±  kb
transcript OTTMUST00000038659 VEGA | MGI Sequence Detail 1862 Not Applicable 
polypeptide OTTMUSP00000017293 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000004515 aurora kinase A
References
(Earliest) J:5970 Ferguson JM, et al., A new type of chondrodystrophic mutant in the mouse. J Med Genet. 1978 Apr;15(2):128-31
(Latest) J:218831 Hill RM, et al., Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer Cell. 2015 Jan 12;27(1):72-84
All references(73)
Other
accession IDs
MGI:2139176, MGI:2139368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory