Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATF3
  • Mouse genes Atf3
  • Rat genes Atf3
  • Zfish genes atf3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atf3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Atf3	IDA		Mouse	PMID:12220541
Molecular Function	GO:0003677	DNA binding	Atf3	IDA		Mouse	PMID:11916968
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ATF3	IDA		Human	PMID:16300731
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Atf3	IDA		Rat	PMID:18308734|RGD:39458028
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATF3	IGI	UniProtKB:P35638	Human	PMID:24939851
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ATF3	IDA		Human	PMID:8622660
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Atf3	IDA		Mouse	MGI:MGI:3624470|PMID:16644691
Molecular Function	GO:0042802	identical protein binding	ATF3	IPI	UniProtKB:P18847	Human	PMID:18255255
Molecular Function	GO:0042802	identical protein binding	ATF3	IPI	UniProtKB:P18847	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P05412	Human	PMID:10327051
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q14192	Human	PMID:18255255
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P18848	Human	PMID:19164757
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P05412	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P15336	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17275	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17535	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17544	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P18848	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P53567	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q9NR55	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P15336	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P53567	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q9NR55	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P01100	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P05412	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P15336	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17275	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P18848	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P49715	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P53567	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q15744	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q16520	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q9NR55	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q9ULX9	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:O95644	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P05412	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17275	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17275	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17535	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P17544	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P09936	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P35638	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ATF3	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0046982	protein heterodimerization activity	ATF3	IPI	UniProtKB:P35638	Human	PMID:8622660
Molecular Function	GO:0042803	protein homodimerization activity	ATF3	IDA		Human	PMID:8622660
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf3	IDA		Mouse	MGI:MGI:3624470|PMID:16644691
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Atf3	IDA		Rat	PMID:18308734|RGD:39458028
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ATF3	IDA		Human	PMID:2516827
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ATF3	IDA		Human	PMID:8622660
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ATF3	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ATF3	IDA		Human	PMID:24939851
Cellular Component	GO:1990622	CHOP-ATF3 complex	ATF3	IDA		Human	PMID:8622660
Cellular Component	GO:0005730	nucleolus	ATF3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ATF3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ATF3	IDA		Human	PMID:7515060
Cellular Component	GO:0005634	nucleus	ATF3	IDA		Human	PMID:8622660
Cellular Component	GO:0005634	nucleus	Atf3	IDA		Mouse	MGI:MGI:3722921|PMID:14729979
Cellular Component	GO:0005634	nucleus	Atf3	IDA		Mouse	PMID:19796622
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ATF3	IPI		Human	PMID:20102225
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ATF3	IPI		Human	PMID:23661758
Biological Process	GO:0034198	cellular response to amino acid starvation	Atf3	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Atf3	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0006094	gluconeogenesis	Atf3	IDA		Mouse	PMID:11916968
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Atf3	IDA		Mouse	PMID:11916968
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Atf3	IMP		Mouse	MGI:MGI:5297260|PMID:22053207
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ATF3	IDA		Human	PMID:7515060
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ATF3	IDA		Human	PMID:8622660
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Atf3	IDA		Mouse	MGI:MGI:3624470|PMID:16644691
Biological Process	GO:0008284	positive regulation of cell population proliferation	Atf3	IMP		Rat	PMID:15990869|RGD:1578388
Biological Process	GO:0010628	positive regulation of gene expression	Atf3	IGI	UniProtKB:P02340	Mouse	MGI:MGI:5621258|PMID:24939851
Biological Process	GO:0010628	positive regulation of gene expression	Atf3	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	ATF3	IMP		Human	PMID:24939851
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF3	IDA		Human	PMID:16300731
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf3	IDA		Rat	PMID:18308734|RGD:39458028
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF3	IDA		Human	PMID:24939851
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ATF3	IDA		Human	PMID:8622660
Biological Process	GO:0010033	response to organic substance	Atf3	IDA		Mouse	PMID:29670287
Biological Process	GO:0009615	response to virus	atf3	IDA		Zfish	PMID:17371995
Biological Process	GO:0035914	skeletal muscle cell differentiation	Atf3	IMP		Mouse	PMID:22147266

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern