About   Help   FAQ
Atf3
Gene Detail
Symbol

Name
ID
Atf3
activating transcription factor 3
MGI:109384
Synonyms
LRG-21
Feature Type
protein coding gene
Genetic Map
Chromosome 1
96.28 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:191170296-191218039 bp, - strand
From VEGA annotation of GRCm38

  47744 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATF3
Protein SuperFamily: fos transforming protein
Gene Tree: Atf3

Human
homologs
ATF3, activating transcription factor 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 467
neXtProt AC: NX_P18847

Human Chr (Location): 1q32.3; chr1:212565334-212620777 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mice display enhanced allergen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine and Th2 cytokine responses in lung tissue and lung-derived CD4+ lymphocytes. Primary pancreatic islets are partially protected from cytokine- or nitric oxide-induced apoptosis.
 
Interactions
Atf3 interacts with 196 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular response to amino acid starvation, endoplasmic reticulum unfolded protein response, ...
Component CHOP-ATF3 complex, nucleolus, ...
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (237)    Tissues (198)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 157
RT-PCR 80
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ATF3 ZFIN atf3    NEW 
Molecular
reagents
All nucleic(35) cDNA(32) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021405 (Evidence)
Ensembl Gene Model ENSMUSG00000026628 (Evidence)
Entrez Gene 11910 (Evidence)
UniGene 2706
DFCI TC1582352
DoTS DT.528324, DT.101719279
NIA Mouse Gene Index U022200
Consensus CDS Project CCDS15616.1
International Mouse Phenotyping Consortium Status Atf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021405 VEGA Gene Model | MGI Sequence Detail 47744 C57BL/6J ±  kb
transcript OTTMUST00000050734 VEGA | MGI Sequence Detail 1984 Not Applicable 
polypeptide OTTMUSP00000023761 VEGA | MGI Sequence Detail 181 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(321 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR000837 Fos transforming protein
Protein Ontology PR:000004399 cyclic AMP-dependent transcription factor ATF-3
References
(Earliest) J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
(Latest) J:220317 Tsai WW, et al., ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2699-704
All references(93)
Other
accession IDs
MGD-MRK-38429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory