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Atf3 Gene Detail
Summary
  • Symbol
    Atf3
  • Name
    activating transcription factor 3
  • Synonyms
    LRG-21
  • Feature Type
    protein coding gene
  • IDs
    MGI:109384
    NCBI Gene: 11910
  • Gene Overview
    MyGene.info: ATF3
Location & Maps
more
  • Sequence Map
    Chr1:191170296-191218039 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47744 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 96.28 cM, cytoband H6
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATF3, activating transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATF3, activating transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 467
    neXtProt AC: NX_P18847

  • Chr Location
    1q32.3; chr1:212565334-212620777 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    3
  • Targeted
    8
  • Transgenic
    1
  • Incidental Mutations
    APF
Homozygous null mice display enhanced allergen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine and Th2 cytokine responses in lung tissue and lung-derived CD4+ lymphocytes. Primary pancreatic islets are partially protected from cytokine- or nitric oxide-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021405 VEGA Gene Model | MGI Sequence Detail 47744 C57BL/6J ±  kb
transcript OTTMUST00000050734 VEGA | MGI Sequence Detail 1984 Not Applicable  
polypeptide OTTMUSP00000023761 VEGA | MGI Sequence Detail 181 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    321 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 32
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38429
References
more
  • Summaries
    All 104
    Developmental Gene Expression 14
    Gene Ontology 12
    Phenotypes 46
  • Earliest
    J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
  • Latest
    J:233751 Aung HH, et al., Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res. 2016 Jun;57(6):955-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory