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Atf3
Gene Detail
 Symbol
Name
ID
Atf3
activating transcription factor 3
MGI:109384
Synonyms LRG-21
Feature Type protein coding gene
Genetic Map
Chromosome 1
96.28 cM, cytoband H6
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:191170296-191183340 bp, - strand
From VEGA annotation of GRCm38

  13045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1265  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fos transforming protein
Gene Tree: Atf3

Human
homologs
Human Homolog ATF3, activating transcription factor 3
NCBI Gene ID 467
neXtProt AC  NX_P18847
Human Chr (Location)  1q32.3; chr1:212565334-212620777 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mice display enhanced allergen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine and Th2 cytokine responses in lung tissue and lung-derived CD4+ lymphocytes. Primary pancreatic islets are partially protected from cytokine- or nitric oxide-induced apoptosis.
 
Interactions
Atf3 interacts with 196 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process gluconeogenesis, negative regulation of transcription, DNA-templated, ...
Component nucleolus, nucleus
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (237)    Tissues (198)    Images (24)
Theiler Stages: 2, 3, 4, 5, 16, 17, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 157
RT-PCR 80
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(32) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021405 (Evidence)
Ensembl Gene ModelENSMUSG00000026628 (Evidence)
Entrez Gene11910 (Evidence)
UniGene2706
DFCITC1582352
DoTSDT.101719279, DT.528324
NIA Mouse Gene IndexU022200
Consensus CDS ProjectCCDS15616.1
International Mouse Knockout Project StatusAtf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021405 VEGA Gene Model | MGI Sequence Detail 13045 C57BL/6J ±  kb
transcript OTTMUST00000050734 VEGA | MGI Sequence Detail 1984 Not Applicable 
polypeptide OTTMUSP00000023761 VEGA | MGI Sequence Detail 181 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR000837 Fos transforming protein
Protein Ontology PR:000004399 cyclic AMP-dependent transcription factor ATF-3
References (Earliest) J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
(Latest) J:209298 De Nardo D, et al., High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol. 2014 Feb;15(2):152-60
All references(90)
Other
accession IDs
MGD-MRK-38429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory