Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACHE
  • Mouse genes Ache
  • Rat genes Ache
  • Zfish genes ache
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ache

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	ACHE	IDA		Human	PMID:8349597
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:126256|RGD:2301195
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:14646156|RGD:2301213
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:2731551|RGD:2301205
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:3655326|RGD:2301204
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:4008917|RGD:2301203
Molecular Function	GO:0042166	acetylcholine binding	Ache	IDA		Rat	PMID:8737018|RGD:2301207
Molecular Function	GO:0003990	acetylcholinesterase activity	ACHE	IDA		Human	PMID:1517212
Molecular Function	GO:0003990	acetylcholinesterase activity	ACHE	IMP		Human	PMID:1517212
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Mouse	PMID:7512968
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Mouse	PMID:16434405
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:126256|RGD:2301195
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:14646156|RGD:2301213
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:16052514|RGD:1580870
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:2731551|RGD:2301205
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:334962|RGD:2301197
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:3655326|RGD:2301204
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:4008917|RGD:2301203
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:6854006|RGD:2301199
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:8417155|RGD:724758
Molecular Function	GO:0003990	acetylcholinesterase activity	Ache	IDA		Rat	PMID:8737018|RGD:2301207
Molecular Function	GO:0003990	acetylcholinesterase activity	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:16470869
Molecular Function	GO:0003990	acetylcholinesterase activity	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:11753420
Molecular Function	GO:0003990	acetylcholinesterase activity	ache	IMP	ZFIN:ZDB-GENO-200319-1	Zfish	PMID:29371671
Molecular Function	GO:0003990	acetylcholinesterase activity	ache	IDA		Zfish	PMID:11016933
Molecular Function	GO:0033265	choline binding	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Molecular Function	GO:0004104	cholinesterase activity	ACHE	IDA		Human	PMID:1517212
Molecular Function	GO:0005518	collagen binding	ACHE	IDA		Human	PMID:12524166
Molecular Function	GO:0016787	hydrolase activity	ACHE	IDA		Human	PMID:1517212
Molecular Function	GO:0042802	identical protein binding	Ache	IPI	PR:P21836	Mouse	PMID:8626792
Molecular Function	GO:0043236	laminin binding	ACHE	IDA		Human	PMID:12524166
Molecular Function	GO:0043236	laminin binding	Ache	IPI	PR:P02469	Mouse	PMID:15474030
Molecular Function	GO:0005515	protein binding	ACHE	IPI	UniProtKB:O60888	Human	PMID:10800960
Molecular Function	GO:0005515	protein binding	ACHE	IPI	UniProtKB:Q9Y215	Human	PMID:15526038
Molecular Function	GO:0005515	protein binding	ACHE	IPI	UniProtKB:P06733	Human	PMID:18194455
Molecular Function	GO:0005515	protein binding	ACHE	IPI	UniProtKB:P63244	Human	PMID:18194455
Molecular Function	GO:0005515	protein binding	Ache	IPI	PR:O35348	Mouse	PMID:20053883
Molecular Function	GO:0042803	protein homodimerization activity	ACHE	IPI	UniProtKB:P22303	Human	PMID:12524166
Molecular Function	GO:0043621	protein self-association	Ache	IPI	PR:P21836	Mouse	PMID:8626792
Molecular Function	GO:0017171	serine hydrolase activity	ACHE	IDA		Human	PMID:3954986
Cellular Component	GO:0030424	axon	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0005604	basement membrane	Ache	IDA		Mouse	PMID:7885444
Cellular Component	GO:0009986	cell surface	Ache	IDA		Mouse	PMID:16434405
Cellular Component	GO:0009986	cell surface	Ache	IDA		Rat	PMID:2731551|RGD:2301205
Cellular Component	GO:0005737	cytoplasm	Ache	IDA		Rat	PMID:16052514|RGD:1580870
Cellular Component	GO:0030425	dendrite	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0005576	extracellular region	ACHE	IDA		Human	PMID:1517212
Cellular Component	GO:0005615	extracellular space	Ache	IDA		Mouse	PMID:16434405
Cellular Component	GO:0005615	extracellular space	Ache	IDA		Mouse	PMID:8626792
Cellular Component	GO:0005794	Golgi apparatus	ACHE	IDA		Human	PMID:15454088
Cellular Component	GO:0005794	Golgi apparatus	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0016020	membrane	ACHE	IDA		Human	PMID:16262697
Cellular Component	GO:0031594	neuromuscular junction	Ache	IDA		Mouse	PMID:7885444
Cellular Component	GO:0031594	neuromuscular junction	Ache	IDA		Rat	PMID:26820598|RGD:12050110
Cellular Component	GO:0043005	neuron projection	Ache	IDA		Rat	PMID:16052514|RGD:1580870
Cellular Component	GO:0043025	neuronal cell body	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0005635	nuclear envelope	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ACHE	IDA		Human	PMID:14766237
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ache	IDA		Rat	PMID:16052514|RGD:1580870
Cellular Component	GO:0005886	plasma membrane	Ache	IDA		Mouse	PMID:8626792
Cellular Component	GO:0005886	plasma membrane	Ache	IDA		Rat	PMID:2731551|RGD:2301205
Cellular Component	GO:0045211	postsynaptic membrane	Ache	IDA		Rat	PMID:3655326|RGD:2301204
Cellular Component	GO:0042734	presynaptic membrane	Ache	IDA		Rat	PMID:3655326|RGD:2301204
Cellular Component	GO:0005791	rough endoplasmic reticulum	Ache	IDA		Rat	PMID:2731551|RGD:2301205
Cellular Component	GO:0045202	synapse	ACHE	IDA		Human	PMID:8460160
Cellular Component	GO:0045202	synapse	Ache	IDA		Mouse	PMID:12533614
Cellular Component	GO:0045202	synapse	Ache	IDA		Mouse	PMID:10995443
Cellular Component	GO:0045202	synapse	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Cellular Component	GO:0043083	synaptic cleft	Ache	IDA		Rat	PMID:26820598|RGD:12050110
Biological Process	GO:0006581	acetylcholine catabolic process	ACHE	IDA		Human	PMID:1517212
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Mouse	PMID:16434405
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Mouse	PMID:7512968
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:126256|RGD:2301195
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:14646156|RGD:2301213
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:16052514|RGD:1580870
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:2731551|RGD:2301205
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:334962|RGD:2301197
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:3655326|RGD:2301204
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:4008917|RGD:2301203
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:6854006|RGD:2301199
Biological Process	GO:0006581	acetylcholine catabolic process	Ache	IDA		Rat	PMID:8737018|RGD:2301207
Biological Process	GO:0006581	acetylcholine catabolic process	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:11753420
Biological Process	GO:0006581	acetylcholine catabolic process	ache	IDA		Zfish	PMID:11016933
Biological Process	GO:0008291	acetylcholine metabolic process	Ache	IMP		Rat	PMID:16628397|RGD:1580871
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Ache	IMP	MGI:MGI:2179948	Mouse	PMID:14645660
Biological Process	GO:0007155	cell adhesion	ACHE	IDA		Human	PMID:15454088
Biological Process	GO:0071405	cellular response to methanol	ache	IDA		Zfish	PMID:16806813
Biological Process	GO:0019695	choline metabolic process	Ache	IDA		Rat	PMID:1133098|RGD:2301187
Biological Process	GO:0019695	choline metabolic process	Ache	IMP		Rat	PMID:16628397|RGD:1580871
Biological Process	GO:0019695	choline metabolic process	Ache	IDA		Rat	PMID:8737018|RGD:2301207
Biological Process	GO:0030239	myofibril assembly	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:11753420
Biological Process	GO:0007528	neuromuscular junction development	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:11753420
Biological Process	GO:0048666	neuron development	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:11753420
Biological Process	GO:0002076	osteoblast development	ACHE	IEP		Human	PMID:15454088
Biological Process	GO:0050772	positive regulation of axonogenesis	Ache	IMP		Rat	PMID:12799140|RGD:1299197
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ache	IMP		Mouse	MGI:MGI:3814169|PMID:17038428
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Ache	IMP		Rat	PMID:12799140|RGD:1299197
Biological Process	GO:0031623	receptor internalization	Ache	IMP	MGI:MGI:2179948	Mouse	PMID:14645660
Biological Process	GO:0001919	regulation of receptor recycling	Ache	IMP	MGI:MGI:2179948	Mouse	PMID:14645660
Biological Process	GO:0050803	regulation of synapse structure or activity	ache	IMP	ZFIN:ZDB-GENO-980410-299	Zfish	PMID:15136152
Biological Process	GO:0050803	regulation of synapse structure or activity	ache	IMP	ZFIN:ZDB-GENO-980202-1527	Zfish	PMID:15136152
Biological Process	GO:0001975	response to amphetamine	ache	IMP	ZFIN:ZDB-GENO-060811-8	Zfish	PMID:16470869
Biological Process	GO:0046677	response to antibiotic	Ache	IDA		Rat	PMID:28173138|RGD:11535337
Biological Process	GO:0046686	response to cadmium ion	Ache	IEP		Rat	PMID:27491636|RGD:152995409
Biological Process	GO:0045471	response to ethanol	ache	IDA		Zfish	PMID:17888594
Biological Process	GO:0009749	response to glucose	ache	IDA		Zfish	PMID:25157430
Biological Process	GO:0032868	response to insulin	Ache	IDA		Rat	PMID:19347982|RGD:150517552
Biological Process	GO:0060041	retina development in camera-type eye	Ache	IMP	MGI:MGI:2179948	Mouse	PMID:15579149
Biological Process	GO:0007416	synapse assembly	Ache	IMP		Rat	PMID:12799140|RGD:1299197

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern