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Ache
Gene Detail
Symbol

Name
ID
Ache
acetylcholinesterase
MGI:87876
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:137287519-137294466 bp, + strand
From VEGA annotation of GRCm38

  6948 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACHE
Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Ache

Human
homologs
ACHE, acetylcholinesterase (Yt blood group)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 43
neXtProt AC: NX_P22303

Human Synonyms: ACEE, ARACHE, N-ACHE, YT

Human Chr (Location): 7q22; chr7:100889994-100896686 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show retarded postnatal development, tremors, impaired righting response, delayed maturation of external ear, failure of eyelids to open, and die by 3-wk. of age. Mutants are highly sensitive to butyrylcholinesterase inhibitor toxicity.
 
Interactions
Ache interacts with 72 markers (Mir16-1, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (61 records)
Data Summary: Results (407)    Tissues (167)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 308
RT-PCR 86
RNase protection 10
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100490673 ; ZFIN ache    NEW 
Molecular
reagents
All nucleic(38) Genomic(7) cDNA(27) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021643 (Evidence)
Ensembl Gene Model ENSMUSG00000023328 (Evidence)
Entrez Gene 11423 (Evidence)
DFCI TC1582401, TC1607531, TC1708696, TC1719066
NIA Mouse Gene Index U006316
EC 3.1.1.-, 3.1.1.7
PDB 1C2B, 1C2O, 1MAA, 1MAH, 1N5M, 1N5R, 2C0P, 2C0Q, 2GYU, 2GYV, 2GYW, 2H9Y, 2JEY, 2JEZ, 2JGE, 2JGF, 2JGI, 2JGJ, 2JGK, 2JGL, 2JGM, 2WHP, 2WHQ, 2WHR, 2WLS, 2XUD, 2XUF, 2XUG, 2XUH, 2XUI, 2XUJ, 2XUK, 2XUO, 2XUP, 2XUQ, 2Y2U, 2Y2V, 3ZLT, 3ZLU, 3ZLV, 4ARA, 4ARB, 4B7Z, 4BTL, 1J06, 1J07, 1KU6, 1Q83, 1Q84, 2HA0, 2HA2, 2HA3, 2HA4, 2HA5, 2HA6, 2HA7, 2JF0, 2WU3, 2WU4, 3DL4, 3DL7, 4A16, 4A23, 4B80, 4B81, 4B82, 4B83, 4B84, 4B85, 4BC0, 4BC1
Consensus CDS Project CCDS19763.1
International Mouse Phenotyping Consortium Status Ache
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021643 VEGA Gene Model | MGI Sequence Detail 6948 C57BL/6J ±  kb
transcript OTTMUST00000051379 VEGA | MGI Sequence Detail 2186 Not Applicable 
polypeptide OTTMUSP00000024159 VEGA | MGI Sequence Detail 614 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(13) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014788 Acetylcholinesterase, tetramerisation
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000997 Cholinesterase
Protein Ontology PR:000003626 acetylcholinesterase
References
(Earliest) J:13986 Sweet HO, Wasted linkage. Mouse News Lett. 1984;71:31
(Latest) J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
All references(157)
Other
accession IDs
MGD-MRK-1035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory