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Ache
Gene Detail
 Symbol
Name
ID
Ache
acetylcholinesterase
MGI:87876
Feature Type protein coding gene
Genetic Map
Chromosome 5
76.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:137287519-137294466 bp, + strand
From VEGA annotation of GRCm38

  6948 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Ache

Human
homologs
Human Homolog ACHE, acetylcholinesterase (Yt blood group)
NCBI Gene ID 43
neXtProt AC  NX_P22303
Human Synonyms  ACEE, ARACHE, N-ACHE, YT
Human Chr (Location)  7q22; chr7:100889994-100896914 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show retarded postnatal development, tremors, impaired righting response, delayed maturation of external ear, failure of eyelids to open, and die by 3-wk. of age. Mutants are highly sensitive to butyrylcholinesterase inhibitor toxicity.
 
Interactions
Ache interacts with 72 markers (Mir16-1, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process acetylcholine catabolic process, acetylcholine metabolic process, ...
Component anchored component of membrane, axon, ...
Function acetylcholine binding, acetylcholinesterase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (407)    Tissues (165)    Images (43)
Theiler Stages: 19, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 308
RT-PCR 86
RNase protection 10
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(7) cDNA(27) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021643 (Evidence)
Ensembl Gene ModelENSMUSG00000023328 (Evidence)
Entrez Gene11423 (Evidence)
DFCITC1582401, TC1607531, TC1708696, TC1719066
NIA Mouse Gene IndexU006316
EC3.1.1.7
PDB1C2B, 1C2O, 1MAA, 1MAH, 1N5M, 1N5R, 2C0P, 2C0Q, 2GYU, 2GYV, 2GYW, 2H9Y, 2JEY, 2JEZ, 2JGE, 2JGF, 2JGI, 2JGJ, 2JGK, 2JGL, 2JGM, 2WHP, 2WHQ, 2WHR, 2WLS, 2XUD, 2XUF, 2XUG, 2XUH, 2XUI, 2XUJ, 2XUK, 2XUO, 2XUP, 2XUQ, 2Y2U, 2Y2V, 3ZLT, 3ZLU, 3ZLV, 4ARA, 4ARB, 4B7Z, 4BTL, 1J06, 1J07, 1KU6, 1Q83, 1Q84, 2HA0, 2HA2, 2HA3, 2HA4, 2HA5, 2HA6, 2HA7, 2JF0, 2WU3, 2WU4, 3DL4, 3DL7, 4A16, 4A23, 4B80, 4B81, 4B82, 4B83, 4B84, 4B85, 4BC0, 4BC1
Consensus CDS ProjectCCDS19763.1
International Mouse Knockout Project StatusAche
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021643 VEGA Gene Model | MGI Sequence Detail 6948 C57BL/6J ±  kb
transcript OTTMUST00000051379 VEGA | MGI Sequence Detail 2186 Not Applicable 
polypeptide OTTMUSP00000024159 VEGA | MGI Sequence Detail 614 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(11) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014788 Acetylcholinesterase, tetramerisation
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000997 Cholinesterase
Protein Ontology PR:000003626 acetylcholinesterase
References (Earliest) J:13986 Sweet HO, Wasted linkage. Mouse News Lett. 1984;71:31
(Latest) J:195321 Mineur YS, et al., Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3573-8
All references(156)
Other
accession IDs
MGD-MRK-1035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory