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Ache Gene Detail
Summary
  • Symbol
    Ache
  • Name
    acetylcholinesterase
  • Feature Type
    protein coding gene
  • IDs
    MGI:87876
    NCBI Gene: 11423
  • Gene Overview
    MyGene.info: ACHE
Location & Maps
more
  • Sequence Map
    Chr5:137287519-137294466 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6948 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ACHE, acetylcholinesterase (Cartwright blood group)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACHE, acetylcholinesterase (Cartwright blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACEE, ARACHE, N-ACHE, YT
  • Links
    NCBI Gene ID: 43
    neXtProt AC: NX_P22303

  • Chr Location
    7q22; chr7:100889994-100896686 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 7 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutants show retarded postnatal development, tremors, impaired righting response, delayed maturation of external ear, failure of eyelids to open, and die by 3-wk. of age. Mutants are highly sensitive to butyrylcholinesterase inhibitor toxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021643 VEGA Gene Model | MGI Sequence Detail 6948 C57BL/6J ±  kb
transcript OTTMUST00000051379 VEGA | MGI Sequence Detail 2186 Not Applicable  
polypeptide OTTMUSP00000024159 VEGA | MGI Sequence Detail 614 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 7
    cDNA 27
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1035
References
more
  • Summaries
    All 157
    Developmental Gene Expression 62
    Gene Ontology 14
    Phenotypes 24
  • Earliest
    J:13986 Sweet HO, Wasted linkage. Mouse News Lett. 1984;71:31
  • Latest
    J:225521 Garcia-Lopez R, et al., Developmental alterations of the septohippocampal cholinergic projection in a lissencephalic mouse model. Exp Neurol. 2015 Sep;271:215-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory