Gene Expression Literature Summary

• Symbol: Ache
• Name: acetylcholinesterase
• ID: MGI:87876

68 matching records from 68 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E10	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1	1	2	1	1		5		1				1		1	2	8	4	18
In situ RNA (section)				1			1	1	3		1	1		1			1	1	3
Immunohistochemistry (whole mount)			1	1	1		1		1		2			1	1				6
In situ RNA (whole mount)																	1
RT-PCR				2	1	1		1	1	2		2	1	1		1	2		9
RNase protection																1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ache  acetylcholinesterase
Results	Reference
2	J:29481 al-Fakhri N, Bogusch G, Activity of acetylcholinesterase and unspecific cholinesterase during differentiation of somites in mouse embryos. Anat Embryol (Berl). 1995 Sep;192(3):257-64
4*	J:41991 Andres C, Beeri R, Friedman A, Lev-Lehman E, Henis S, Timberg R , Shani M , Soreq H, Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8173-8
1	J:230224 Aoki H, Hara A, Oomori Y, Shimizu Y, Yamada Y, Kunisada T, Neonatal lethality of neural crest cell-specific Rest knockout mice is associated with gastrointestinal distension caused by aberrations of myenteric plexus. Genes Cells. 2014 Oct;19(10):723-42
1	J:116089 Asai N, Fukuda T, Wu Z, Enomoto A, Pachnis V, Takahashi M, Costantini F, Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development. 2006 Nov;133(22):4507-16
1	J:152698 Baguma-Nibasheka M, Kablar B, Abnormal retinal development in the Btrc null mouse. Dev Dyn. 2009 Aug 24;238(10):2680-2687
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:61535 Bishop KM, Goudreau G, O'Leary DD, Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science. 2000 Apr 14;288(5464):344-9
1	J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
2	J:81738 Brandon EP, Lin W, D'Amour KA, Pizzo DP, Dominguez B, Sugiura Y, Thode S, Ko CP, Thal LJ, Gage FH, Lee KF, Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci. 2003 Jan 15;23(2):539-49
1*	J:64996 Burgess RW, Skarnes WC, Sanes JR, Agrin isoforms with distinct amino termini. Differential expression, localization, and function. J Cell Biol. 2000 Oct 2;151(1):41-52
1	J:296198 Cardinal T, Bergeron KF, Soret R, Souchkova O, Faure C, Guillon A, Pilon N, Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression. PLoS Genet. 2020 Sep;16(9):e1009008
1	J:341393 Cheffer A, Garcia-Miralles M, Maier E, Akol I, Franz H, Srinivasan VSV, Vogel T, DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285
1*	J:132651 Cho G, Lim Y, Zand D, Golden JA, Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling. Mol Cell Biol. 2008 Mar;28(5):1565-72
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:345130 Eguchi T, Tezuka T, Watanabe Y, Inoue-Yamauchi A, Sagara H, Ozawa M, Yamanashi Y, Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997
1	J:133494 Elshatory Y, Gan L, The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci. 2008 Mar 26;28(13):3291-7
1	J:26749 Ernfors P, Van De Water T, Loring J, Jaenisch R, Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron. 1995 Jun;14(6):1153-64
1	J:54931 Finotto S, Krieglstein K, Schober A, Deimling F, Lindner K, Bruhl B, Beier K, Metz J, Garcia-Arraras JE, Roig-Lopez JL, Monaghan P, Schmid W, Cole TJ, Kellendonk C, Tronche F, Schutz G, Unsicker K, Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development. 1999 Jul;126(13):2935-44
1	J:101205 Fragkouli A, Hearn C, Errington M, Cooke S, Grigoriou M, Bliss T, Stylianopoulou F, Pachnis V, Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci. 2005 Jun;21(11):2923-38
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:189007 Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG, Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov;139(21):4007-19
2	J:225521 Garcia-Lopez R, Pombero A, Dominguez E, Geijo-Barrientos E, Martinez S, Developmental alterations of the septohippocampal cholinergic projection in a lissencephalic mouse model. Exp Neurol. 2015 Sep;271:215-27
1	J:33098 Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR, Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
1*	J:64178 Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, Favier R, Bernstein A, Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000 Aug;13(2):167-77
1	J:191332 Henry AM, Hohmann JG, High-resolution gene expression atlases for adult and developing mouse brain and spinal cord. Mamm Genome. 2012 Oct;23(9-10):539-49
1	J:53261 Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM Jr, Milbrandt J, Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999 Feb;22(2):253-63
1	J:253459 Inoue SI, Takahara S, Yoshikawa T, Niihori T, Yanai K, Matsubara Y, Aoki Y, Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017 Dec 1;26(23):4715-4727
1*	J:260151 Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, Konishi H, Masuda A, Imagama S, Kiyama H, Ishiguro N, Ohno K, Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. Sci Rep. 2018 Jan 11;8(1):434
1	J:224337 Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q, Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol. 2014 Oct;34(20):3895-910
1	J:68443 Kitajima K, Kojima M, Kondo S, Takeuchi T, A role of jumonji gene in proliferation but not differentiation of megakaryocyte lineage cells. Exp Hematol. 2001 Apr;29(4):507-14
1	J:152416 Kitamura K, Itou Y, Yanazawa M, Ohsawa M, Suzuki-Migishima R, Umeki Y, Hohjoh H, Yanagawa Y, Shinba T, Itoh M, Nakamura K, Goto Y, Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum Mol Genet. 2009 Oct 1;18(19):3708-24
1	J:132605 Kreuzberg MM, Deuchars J, Weiss E, Schober A, Sonntag S, Wellershaus K, Draguhn A, Willecke K, Expression of connexin30.2 in interneurons of the central nervous system in the mouse. Mol Cell Neurosci. 2008 Jan;37(1):119-34
1	J:216600 Lau CG, Marikawa Y, Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
1	J:316483 Leek CC, Soulas JM, Bhattacharya I, Ganji E, Locke RC, Smith MC, Bhavsar JD, Polson SW, Ornitz DM, Killian ML, Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments. Dev Dyn. 2021 Dec;250(12):1778-1795
6	J:28879 Legay C, Huchet M, Massoulie J, Changeux JP, Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalization. Eur J Neurosci. 1995 Aug 1;7(8):1803-9
1	J:185422 Liu Y, Sugiura Y, Wu F, Mi W, Taketo MM, Cannon S, Carroll T, Lin W, beta-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice. Dev Biol. 2012 Jun 15;366(2):255-67
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
2*	J:34235 Luo ZD, Pincon-Raymond M, Taylor P, Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channel. J Neurochem. 1996 Jul;67(1):111-8
1	J:126323 Machon O, Backman M, Machonova O, Kozmik Z, Vacik T, Andersen L, Krauss S, A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol. 2007 Nov 1;311(1):223-37
1	J:184343 Magno L, Kretz O, Bert B, Ersozlu S, Vogt J, Fink H, Kimura S, Vogt A, Monyer H, Nitsch R, Naumann T, The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci. 2011 Dec;34(11):1767-82
1	J:91066 Misgeld T, Burgess RW, Lewis RM, Cunningham JM, Lichtman JW, Sanes JR, Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron. 2002 Nov 14;36(4):635-48
2	J:42772 Motoyama J, Kitajima K, Kojima M, Kondo S, Takeuchi T, Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice. Mech Dev. 1997 Aug;66(1-2):27-37
1	J:182762 Mundell NA, Plank JL, LeGrone AW, Frist AY, Zhu L, Shin MK, Southard-Smith EM, Labosky PA, Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol. 2012 Mar 15;363(2):373-87
1	J:309176 Nakajima K, Miranda A, Craig DW, Shekhtman T, Kmoch S, Bleyer A, Szelinger S, Kato T, Kelsoe JR, Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. Transl Psychiatry. 2020 Nov 24;10(1):407
8	J:19577 Nakao T, Ishizawa A, Development of the spinal nerves in the mouse with special reference to innervation of the axial musculature. Anat Embryol (Berl). 1994 Feb;189(2):115-38
1	J:105646 Oberle S, Schober A, Meyer V, Holtmann B, Henderson C, Sendtner M, Unsicker K, Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla. J Neurosci. 2006 Feb 8;26(6):1823-32
2	J:81765 Pabst O, Rummelies J, Winter B, Arnold HH, Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve. Development. 2003 Mar;130(6):1193-202
4*	J:25043 Pernas-Alonso R, Schaffner AE, Hansen CT, Barker JL, di Porzio U, Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse. Neuroreport. 1995 Mar 7;6(4):597-600
1	J:93814 Reddy T, Kablar B, Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos. Dev Dyn. 2004 Dec;231(4):683-92
1	J:156036 Schilling K, Oberdick J, The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Cerebellum. 2009 Dec;8(4):477-89
1*	J:70507 Smith CL, Mittaud P, Prescott ED, Fuhrer C, Burden SJ, Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors. J Neurosci. 2001 May 1;21(9):3151-60
1	J:245905 Spieker J, Mudersbach T, Vogel-Hopker A, Layer PG, Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PLoS One. 2017;12(1):e0170252
1	J:81762 Stenman J, Yu RT, Evans RM, Campbell K, Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003 Mar;130(6):1113-22
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:83004 Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J, FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 2003 Apr 15;22(8):1811-23
1	J:77237 Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Sudhof TC, Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science. 2000 Feb 4;287(5454):864-9
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:116618 Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO, Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Dev Dyn. 2007 Jan;236(1):106-17
1	J:73864 Wallen A A, Castro DS, Zetterstrom RH, Karlen M, Olson L, Ericson J, Perlmann T, Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem. Mol Cell Neurosci. 2001 Dec;18(6):649-63
1	J:157942 Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BP, Keller-Peck C, Heuckeroth RO, The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. J Neurosci. 2010 Jan 27;30(4):1523-38
1	J:117866 Warren M, Wang W, Spiden S, Chen-Murchie D, Tannahill D, Steel KP, Bradley A, A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. Genesis. 2007 Jan;45(1):51-8
1	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1	J:58105 Woldeyesus MT, Britsch S, Riethmacher D, Xu L, Sonnenberg-Riethmacher E, Abou-Rebyeh F, Harvey R, Caroni P, Birchmeier C, Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 1999 Oct 1;13(19):2538-48
1	J:185531 Wu H, Lu Y, Barik A, Joseph A, Taketo MM, Xiong WC, Mei L, beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
2	J:317553 Wu WL, Adams CE, Stevens KE, Chow KH, Freedman R, Patterson PH, The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain Behav Immun. 2015 May;46:192-202
1	J:42478 Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW Jr, Klein W , Nathans J, Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9445-50
4	J:63363 Zhang L, Yoshimura Y, Hatta T, Otani H, Reconstructing the pathway of the tensor veli palatini motor nerve during early mouse development. Anat Embryol (Berl). 2000 Apr;201(4):235-44
1	J:304122 Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H, Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells. 2020 Jul 17;9(7):1714