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All mouse models of congenital heart disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | atrial heart septal defect 2 | Gata4tm1Grg/Gata4+ | involves: 129 * C57BL/6 | J:185124 | View | |||
| atrial heart septal defect 7 | Nkx2-5tm2.1Mwc/Nkx2-5+ | B6J.Cg-Nkx2-5tm2.1Mwc/Mwc | J:239808 | View | ||||
| atrial heart septal defect 7 | Nkx2-5tm3.1Mwc/Nkx2-5+ | B6J.Cg-Nkx2-5tm3.1Mwc/Mwc | J:239808 | View | ||||
| Char syndrome | Tfap2btm1Rbu/Tfap2btm1Rbu | involves: 129S1/Sv * 129X1/SvJ | J:175832 | View | ||||
| congenital heart disease | Nkx2-5tm1.1Burg/Nkx2-5+ | involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ | J:251389 | View | ||||
| congenital heart disease | Nkx2-5tm1.1Hkas/Nkx2-5+ | 129S2.Cg-Nkx2-5tm1.1Hkas | J:273096, J:273097 | View | ||||
| hypoplastic left heart syndrome | Nkx2-5tm2.1Mwc/Nkx2-5+ | B6J.Cg-Nkx2-5tm2.1Mwc/Mwc | J:239808 | View | ||||
| hypoplastic left heart syndrome | Nkx2-5tm3.1Mwc/Nkx2-5+ | B6J.Cg-Nkx2-5tm3.1Mwc/Mwc | J:239808 | View | ||||
| patent ductus arteriosus | Tfap2bem1Fenli/Tfap2bem1Fenli | involves: C57BL/6 | J:278067 | View | ||||
| tetralogy of Fallot | Gja5tm1Paul/Gja5+ | involves: 129S4/SvJae * C57BL/6 | J:109301 | View | ||||
| tetralogy of Fallot | Gja5tm1Paul/Gja5tm1Paul | involves: 129S4/SvJae * C57BL/6 | J:109301 | View | ||||
| tetralogy of Fallot | Nkx2-5tm2.1Mwc/Nkx2-5+ | B6J.Cg-Nkx2-5tm2.1Mwc/Mwc | J:239808 | View | ||||
| tetralogy of Fallot | Nkx2-5tm3.1Mwc/Nkx2-5+ | B6J.Cg-Nkx2-5tm3.1Mwc/Mwc | J:239808 | View | ||||
| tetralogy of Fallot | Zfpm2tm1Sho/Zfpm2tm1Sho | involves: 129S1/Sv | J:62879, J:78688 | View | ||||
| | atrial heart septal defect 1 | avc2/avc2 | involves: C57BL/6J * FVB/N | J:163196 | View | |||
| atrial heart septal defect 1 | Ccn1tm1Lfl/Ccn1+ | involves: 129S4/SvJae * C57BL/6J | J:126490 | View | ||||
| atrial heart septal defect 1 | Ntf3tm1Par/Ntf3tm1Par | involves: 129S1/Sv | J:35639 | View | ||||
| atrial heart septal defect 1 | pta/pta | C57BL/6J-pta | J:94456 | View | ||||
| atrioventricular septal defect | avc3/avc3 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect |
Bmp4tm1Blh/Bmp4tm3.1Blh Tg(Tnnt2-cre)5Blh/0 |
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR | J:86001 | View | ||||
| atrioventricular septal defect |
Bmp4tm3.1Blh/Bmp4tm3.1Blh Tg(Tnnt2-cre)5Blh/0 |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR | J:86001 | View | ||||
| atrioventricular septal defect | Ccn1tm1Lfl/Ccn1tm1Lfl | involves: 129S4/SvJae * C57BL/6J | J:126490 | View | ||||
| atrioventricular septal defect | Dnah11avc4/Dnah11avc4 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect |
Gata4tm1.1Sad/Gata4+ Glyr1em1Dsr/Glyr1+ Tg(Tek-cre)1Ywa/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL | J:322763 | View | ||||
| atrioventricular septal defect | Glyr1em1Dsr/Glyr1em1Dsr | involves: C57BL/6J | J:322763 | View | ||||
| atrioventricular septal defect | Ift172avc1/Ift172avc1 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect | l11Jus16/l11Jus16 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect | Mks1avc6/Mks1avc6 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect | Nr1d2tm1Dgen/Nr1d2tm1Dgen | B6;129P2-Nr1d2tm1Dgen/H | J:232480 | View | ||||
| atrioventricular septal defect | pta/pta | C57BL/6J-pta | J:94456 | View | ||||
| congenital heart disease | b2b243.1Clo/b2b243.1Clo | C57BL/6J-b2b243.1Clo | J:175213 | View | ||||
| congenital heart disease | b2b243Clo/b2b243Clo | C57BL/6J-b2b243Clo | J:175213 | View | ||||
| congenital heart disease | b2b520Clo/b2b520Clo | C57BL/6J-b2b520Clo | J:175213 | View | ||||
| congenital heart disease | b2b913Clo/b2b913Clo | C57BL/6J-b2b913Clo | J:175213 | View | ||||
| congenital heart disease | b2b1639Clo/b2b1639Clo | C57BL/6J-b2b1639Clo | J:175213 | View | ||||
| congenital heart disease | Foxj1tm1.1(cre/ERT2/GFP)Htg/Foxj1tm1.1(cre/ERT2/GFP)Htg | STOCK Foxj1tm1.1(cre/ERT2/GFP)Htg/J | J:342078 | View | ||||
| congenital heart disease | Rxratm1Rev/Rxra+ | involves: 129S4/SvJae * C57BL/6 | J:35363 | View | ||||
| congenital heart disease | Sap130b2b635.2Clo/Sap130b2b635.2Clo | C57BL/6J-Sap130b2b635.2Clo | J:242757 | View | ||||
| congenital heart disease | Sap130b2b635.2Clo/Sap130b2b635.2Clo | C57BL/6J-Sap130b2b635.2Clo Pcdha9b2b635.1Clo | J:242757 | View | ||||
| dextro-looped transposition of the great arteries | Cfc1tm1Cbm/Cfc1tm1Cbm | Not Specified | J:58530 | View | ||||
| dextro-looped transposition of the great arteries | Dvl2tm1Awb/Dvl2tm1Awb | either: 129S6/SvEvTac-Dvl2tm1Awb or (involves: 129S6/SvEvTac * NIH Swiss) | J:96661 | View | ||||
| dextro-looped transposition of the great arteries | Hspg2tm1Ref/Hspg2tm1Ref | involves: 129S1/Sv * 129X1/SvJ | J:80720, J:107987 | View | ||||
| double outlet right ventricle | Cfc1tm1Cbm/Cfc1tm1Cbm | Not Specified | J:58530 | View | ||||
| double outlet right ventricle | Ece1tm1Reh/Ece1tm1Reh | involves: 129S6/SvEvTac * C57BL/6J | J:62261 | View | ||||
| double outlet right ventricle |
Ece1tm1Reh/Ece1tm1Reh Ece2tm1Ywa/Ece2tm1Ywa |
involves: 129S6/SvEvTac * C57BL/6J | J:62261 | View | ||||
| hypoplastic left heart syndrome | b2b464Clo/b2b464Clo | C57BL/6J-b2b464Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b635Clo/b2b635Clo | C57BL/6J-b2b635Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b1430Clo/b2b1430Clo | C57BL/6J-b2b1430Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b1432Clo/b2b1432Clo | C57BL/6J-b2b1432Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b1709Clo/b2b1709Clo | C57BL/6J-b2b1709Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b1963Clo/b2b1963Clo | C57BL/6J-b2b1963Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | b2b3183Clo/b2b3183Clo | C57BL/6J-b2b3183Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome |
Pcdha9em1Clo/Pcdha9em1Clo Sap130em1Clo/Sap130em1Clo |
C57BL/6J-Sap130em1Clo Pcdha9em1Clo/MurrJ | J:242757 | View | ||||
| hypoplastic left heart syndrome | Sap130b2b635.2Clo/Sap130b2b635.2Clo | C57BL/6J-Sap130b2b635.2Clo Pcdha9b2b635.1Clo | J:242757 | View | ||||
| patent ductus arteriosus |
Myocdtm1Msp/Myocdtm1Msp H2az2Tg(Wnt1-cre)11Rth/H2az2+ |
involves: 129/Sv * C57BL/6 * CBA | J:131288 | View | ||||
| patent ductus arteriosus |
Myocdtm1Msp/Myocdtm1Msp Tg(Pax3-cre)1Joe/0 |
involves: 129/Sv * C57BL/6 * SJL | J:131288 | View | ||||
| scimitar syndrome |
Ift88tm1Bky/Ift88tm1Rpw Tg(Col1a1-cre)1Bek/0 |
involves: 129 * 129P2/OlaHsd * CD-1 | J:308860 | View | ||||
| scimitar syndrome | Pdgfratm2Sor/Pdgfratm2Sor | involves: 129S4/SvJaeSor | J:157946 | View | ||||
| tetralogy of Fallot | Bmp10b2b2711Clo/Bmp10b2b2711Clo | C57BL/6J-Bmp10b2b2711Clo | J:175213 | View | ||||
| tetralogy of Fallot | Cited2tm1Ycy/Cited2tm1Ycy | involves: C57BL/6J | J:78364 | View | ||||
| tetralogy of Fallot | Del(11Mpo-Chad)18Brd/+ | involves: 129S7/SvEvBrd * C57BL/6 | J:109163 | View | ||||
| tetralogy of Fallot | Dnah5hlb612/Dnah5hlb612 | involves: C57BL/6J | J:130755 | View | ||||
| tetralogy of Fallot | Dock1b2b3190Clo/Dock1b2b3190Clo | C57BL/6J-Dock1b2b3190Clo | J:175213 | View | ||||
| tetralogy of Fallot |
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt Tg(Msx2-cre)5Rem/0 |
involves: 129P2/OlaHsd | J:66266 | View | ||||
| tetralogy of Fallot | Hey2tm1Uts/Hey2tm1Uts | either: (involves: 129X1/SvJ) or (involves: C57BL/6) | J:79025 | View | ||||
| tetralogy of Fallot | Invsinv/Invsinv | FVB/N-Invsinv | J:48533 | View | ||||
| tetralogy of Fallot | Mks1avc6/Mks1avc6 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| tetralogy of Fallot | Ntf3tm1Par/Ntf3tm1Par | involves: 129S1/Sv | J:35639 | View | ||||
| tetralogy of Fallot | Phc1tm1Os/Phc1tm1Os | involves: 129S2/SvPas * C57BL/6 | J:43764 | View | ||||
| | tetralogy of Fallot | Dp(16Lipi-Zbtb21)1Yey/0 | involves: 129S7/SvEvBrd | J:121790 | View | |||
| Transgenes and Other Mutations | dextro-looped transposition of the great arteries | Del(11Mpo-Chad)18Brd/+ | involves: 129S7/SvEvBrd * C57BL/6 | J:109163 | View | |||
| Additional Complex Models | atrial heart septal defect 1 |
Nkx2-5tm4Rph/Nkx2-5+ Tbx20tm1.1Rph/Tbx20+ |
involves: 129S1/Sv * C57BL/6 | J:98489 | View | |||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | hypoplastic left heart syndrome |
Hand1tm5Abfi/Hand1+ Nkx2-5tm1(cre)Rjs/Nkx2-5+ |
involves: 129S7/SvEvBrd | J:311466 | View | |||
| hypoplastic left heart syndrome |
Hand1tm5Abfi/Hand1+ Tg(Mef2c-cre)2Blk/0 |
Not Specified | J:311466 | View | ||||
| hypoplastic left heart syndrome |
Hand1tm5Abfi/Hand1+ Tg(Myh6-cre)2182Mds/0 |
involves: FVB/N | J:311466 | View | ||||