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All mouse models of congenital heart disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | atrial heart septal defect 2 | \Gata4tm1Grg/\Gata4+ | involves: 129 * C57BL/6 | J:185124 | View | |||
| atrial heart septal defect 7 | \Nkx2-5tm2.1Mwc/\Nkx2-5+ | B6J.Cg-Nkx2-5tm2.1Mwc/Mwc | J:239808 | View | ||||
| atrial heart septal defect 7 | \Nkx2-5tm3.1Mwc/\Nkx2-5+ | B6J.Cg-Nkx2-5tm3.1Mwc/Mwc | J:239808 | View | ||||
| Char syndrome | \Tfap2btm1Rbu/\Tfap2btm1Rbu | involves: 129S1/Sv * 129X1/SvJ | J:175832 | View | ||||
| congenital heart disease | \Nkx2-5tm1.1Burg/\Nkx2-5+ | involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ | J:251389 | View | ||||
| congenital heart disease | \Nkx2-5tm1.1Hkas/\Nkx2-5+ | 129S2.Cg-Nkx2-5tm1.1Hkas | J:273096, J:273097 | View | ||||
| hypoplastic left heart syndrome | \Nkx2-5tm2.1Mwc/\Nkx2-5+ | B6J.Cg-Nkx2-5tm2.1Mwc/Mwc | J:239808 | View | ||||
| hypoplastic left heart syndrome | \Nkx2-5tm3.1Mwc/\Nkx2-5+ | B6J.Cg-Nkx2-5tm3.1Mwc/Mwc | J:239808 | View | ||||
| patent ductus arteriosus | \Tfap2bem1Fenli/\Tfap2bem1Fenli | involves: C57BL/6 | J:278067 | View | ||||
| tetralogy of Fallot | \Gja5tm1Paul/\Gja5+ | involves: 129S4/SvJae * C57BL/6 | J:109301 | View | ||||
| tetralogy of Fallot | \Gja5tm1Paul/\Gja5tm1Paul | involves: 129S4/SvJae * C57BL/6 | J:109301 | View | ||||
| tetralogy of Fallot | \Nkx2-5tm2.1Mwc/\Nkx2-5+ | B6J.Cg-Nkx2-5tm2.1Mwc/Mwc | J:239808 | View | ||||
| tetralogy of Fallot | \Nkx2-5tm3.1Mwc/\Nkx2-5+ | B6J.Cg-Nkx2-5tm3.1Mwc/Mwc | J:239808 | View | ||||
| tetralogy of Fallot | \Zfpm2tm1Sho/\Zfpm2tm1Sho | involves: 129S1/Sv | J:62879, J:78688 | View | ||||
| | atrial heart septal defect 1 | \avc2/\avc2 | involves: C57BL/6J * FVB/N | J:163196 | View | |||
| atrial heart septal defect 1 | \Ccn1tm1Lfl/\Ccn1+ | involves: 129S4/SvJae * C57BL/6J | J:126490 | View | ||||
| atrial heart septal defect 1 | \Ntf3tm1Par/\Ntf3tm1Par | involves: 129S1/Sv | J:35639 | View | ||||
| atrial heart septal defect 1 | \pta/\pta | C57BL/6J-pta | J:94456 | View | ||||
| atrioventricular septal defect | \avc3/\avc3 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect |
\Bmp4tm1Blh/\Bmp4tm3.1Blh \Tg(Tnnt2-cre)5Blh/0 |
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR | J:86001 | View | ||||
| atrioventricular septal defect |
\Bmp4tm3.1Blh/\Bmp4tm3.1Blh \Tg(Tnnt2-cre)5Blh/0 |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR | J:86001 | View | ||||
| atrioventricular septal defect | \Ccn1tm1Lfl/\Ccn1tm1Lfl | involves: 129S4/SvJae * C57BL/6J | J:126490 | View | ||||
| atrioventricular septal defect | \Dnah11avc4/\Dnah11avc4 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect |
\Gata4tm1.1Sad/\Gata4+ \Glyr1em1Dsr/\Glyr1+ \Tg(Tek-cre)1Ywa/0 |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL | J:322763 | View | ||||
| atrioventricular septal defect | \Glyr1em1Dsr/\Glyr1em1Dsr | involves: C57BL/6J | J:322763 | View | ||||
| atrioventricular septal defect | \Ift172avc1/\Ift172avc1 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect | \l11Jus16/\l11Jus16 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect | \Mks1avc6/\Mks1avc6 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| atrioventricular septal defect | \Nr1d2tm1Dgen/\Nr1d2tm1Dgen | B6;129P2-Nr1d2tm1Dgen/H | J:232480 | View | ||||
| atrioventricular septal defect | \pta/\pta | C57BL/6J-pta | J:94456 | View | ||||
| congenital heart disease | \b2b243.1Clo/\b2b243.1Clo | C57BL/6J-b2b243.1Clo | J:175213 | View | ||||
| congenital heart disease | \b2b243Clo/\b2b243Clo | C57BL/6J-b2b243Clo | J:175213 | View | ||||
| congenital heart disease | \b2b520Clo/\b2b520Clo | C57BL/6J-b2b520Clo | J:175213 | View | ||||
| congenital heart disease | \b2b913Clo/\b2b913Clo | C57BL/6J-b2b913Clo | J:175213 | View | ||||
| congenital heart disease | \b2b1639Clo/\b2b1639Clo | C57BL/6J-b2b1639Clo | J:175213 | View | ||||
| congenital heart disease | \Foxj1tm1.1(cre/ERT2/GFP)Htg/\Foxj1tm1.1(cre/ERT2/GFP)Htg | STOCK Foxj1tm1.1(cre/ERT2/GFP)Htg/J | J:342078 | View | ||||
| congenital heart disease | \Rxratm1Rev/\Rxra+ | involves: 129S4/SvJae * C57BL/6 | J:35363 | View | ||||
| congenital heart disease | \Sap130b2b635.2Clo/\Sap130b2b635.2Clo | C57BL/6J-Sap130b2b635.2Clo | J:242757 | View | ||||
| congenital heart disease | \Sap130b2b635.2Clo/\Sap130b2b635.2Clo | C57BL/6J-Sap130b2b635.2Clo Pcdha9b2b635.1Clo | J:242757 | View | ||||
| dextro-looped transposition of the great arteries | \Cfc1tm1Cbm/\Cfc1tm1Cbm | Not Specified | J:58530 | View | ||||
| dextro-looped transposition of the great arteries | \Dvl2tm1Awb/\Dvl2tm1Awb | either: 129S6/SvEvTac-Dvl2tm1Awb or (involves: 129S6/SvEvTac * NIH Swiss) | J:96661 | View | ||||
| dextro-looped transposition of the great arteries | \Hspg2tm1Ref/\Hspg2tm1Ref | involves: 129S1/Sv * 129X1/SvJ | J:80720, J:107987 | View | ||||
| dextrocardia | \Cirozb2b1167Clo/\Cirozb2b1167Clo | C57BL/6J-Cirozb2b1167Clo | J:363359 | View | ||||
| double outlet right ventricle | \Cfc1tm1Cbm/\Cfc1tm1Cbm | Not Specified | J:58530 | View | ||||
| double outlet right ventricle | \Ece1tm1Reh/\Ece1tm1Reh | involves: 129S6/SvEvTac * C57BL/6J | J:62261 | View | ||||
| double outlet right ventricle |
\Ece1tm1Reh/\Ece1tm1Reh \Ece2tm1Ywa/\Ece2tm1Ywa |
involves: 129S6/SvEvTac * C57BL/6J | J:62261 | View | ||||
| hypoplastic left heart syndrome | \b2b464Clo/\b2b464Clo | C57BL/6J-b2b464Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b635Clo/\b2b635Clo | C57BL/6J-b2b635Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b1430Clo/\b2b1430Clo | C57BL/6J-b2b1430Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b1432Clo/\b2b1432Clo | C57BL/6J-b2b1432Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b1709Clo/\b2b1709Clo | C57BL/6J-b2b1709Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b1963Clo/\b2b1963Clo | C57BL/6J-b2b1963Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b3077.2Clo/\b2b3077.2Clo | C57BL/6J-b2b3077.2Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b3077Clo/\b2b3077Clo | C57BL/6J-b2b3077Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome | \b2b3183Clo/\b2b3183Clo | C57BL/6J-b2b3183Clo | J:175213 | View | ||||
| hypoplastic left heart syndrome |
\Pcdha9em1Clo/\Pcdha9em1Clo \Sap130em1Clo/\Sap130em1Clo |
C57BL/6J-Sap130em1Clo Pcdha9em1Clo/MurrJ | J:242757 | View | ||||
| hypoplastic left heart syndrome | \Sap130b2b635.2Clo/\Sap130b2b635.2Clo | C57BL/6J-Sap130b2b635.2Clo Pcdha9b2b635.1Clo | J:242757 | View | ||||
| patent ductus arteriosus |
\Myocdtm1Msp/\Myocdtm1Msp \H2az2Tg(Wnt1-cre)11Rth/\H2az2+ |
involves: 129/Sv * C57BL/6 * CBA | J:131288 | View | ||||
| patent ductus arteriosus |
\Myocdtm1Msp/\Myocdtm1Msp \Tg(Pax3-cre)1Joe/0 |
involves: 129/Sv * C57BL/6 * SJL | J:131288 | View | ||||
| scimitar syndrome |
\Ift88tm1Bky/\Ift88tm1Rpw \Tg(Col1a1-cre)1Bek/0 |
involves: 129 * 129P2/OlaHsd * CD-1 | J:308860 | View | ||||
| scimitar syndrome | \Pdgfratm2Sor/\Pdgfratm2Sor | involves: 129S4/SvJaeSor | J:157946 | View | ||||
| tetralogy of Fallot | \Bmp10b2b2711Clo/\Bmp10b2b2711Clo | C57BL/6J-Bmp10b2b2711Clo | J:175213 | View | ||||
| tetralogy of Fallot | \Cited2tm1Ycy/\Cited2tm1Ycy | involves: C57BL/6J | J:78364 | View | ||||
| tetralogy of Fallot | \Del(11Mpo-Chad)18Brd/\+ | involves: 129S7/SvEvBrd * C57BL/6 | J:109163 | View | ||||
| tetralogy of Fallot | \Dnah5hlb612/\Dnah5hlb612 | involves: C57BL/6J | J:130755 | View | ||||
| tetralogy of Fallot | \Dock1b2b3190Clo/\Dock1b2b3190Clo | C57BL/6J-Dock1b2b3190Clo | J:175213 | View | ||||
| tetralogy of Fallot |
\Fgf8tm1.3Mrt/\Fgf8tm1.4Mrt \Tg(Msx2-cre)5Rem/0 |
involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1 * FVB/N | J:66266 | View | ||||
| tetralogy of Fallot | \Hey2tm1Uts/\Hey2tm1Uts | either: (involves: 129X1/SvJ) or (involves: C57BL/6) | J:79025 | View | ||||
| tetralogy of Fallot | \Invsinv/\Invsinv | FVB/N-Invsinv | J:48533 | View | ||||
| tetralogy of Fallot | \Mks1avc6/\Mks1avc6 | involves: C57BL/6J * FVB/N | J:163196 | View | ||||
| tetralogy of Fallot | \Ntf3tm1Par/\Ntf3tm1Par | involves: 129S1/Sv | J:35639 | View | ||||
| tetralogy of Fallot | \Phc1tm1Os/\Phc1tm1Os | involves: 129S2/SvPas * C57BL/6 | J:43764 | View | ||||
| | tetralogy of Fallot | \Dp(16Lipi-Zbtb21)1Yey/0 | involves: 129S7/SvEvBrd | J:121790 | View | |||
| Transgenes and Other Mutations | dextro-looped transposition of the great arteries | \Del(11Mpo-Chad)18Brd/\+ | involves: 129S7/SvEvBrd * C57BL/6 | J:109163 | View | |||
| Additional Complex Models | atrial heart septal defect 1 |
\Nkx2-5tm4Rph/\Nkx2-5+ \Tbx20tm1.1Rph/\Tbx20+ |
involves: 129S1/Sv * C57BL/6 | J:98489 | View | |||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | hypoplastic left heart syndrome |
\Hand1tm5Abfi/\Hand1+ \Nkx2-5tm1(cre)Rjs/\Nkx2-5+ |
involves: 129S7/SvEvBrd | J:311466 | View | |||
| hypoplastic left heart syndrome |
\Hand1tm5Abfi/\Hand1+ \Tg(Mef2c-cre)2Blk/0 |
Not Specified | J:311466 | View | ||||
| hypoplastic left heart syndrome |
\Hand1tm5Abfi/\Hand1+ \Tg(Myh6-cre)2182Mds/0 |
involves: FVB/N | J:311466 | View | ||||