Ccn1^tm1Lfl
Targeted Allele Detail

Summary

• Symbol: Ccn1^tm1Lfl
• Name: cellular communication network factor 1; targeted mutation 1, Lester F Lau
• MGI ID: MGI:2446577
• Synonyms: Ccn1^-, Ccn1^lacZ, Cyr61^-
• Gene: Ccn1 Location: Chr3:145352731-145355736 bp, - strand Genetic Position: Chr3, 70.18 cM
• Alliance: Ccn1^tm1Lfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80618
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 1 and a portion of exon 2 were replaced by a cassette inserted by homologous recombination and containing lacZ and neo. In addition to deleting endogenous sequence, the insertion of the cassette shifted downstream sequence out of frame. Expression analysis of embryonic fibroblasts derived from homozygous mutant mice indicated an absence of both transcript and protein, even after serum stimulation. Expression of lacZ was determined to be driven by the endogenous promoter. (J:80618)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccn1 Mutation: 33 strains or lines available

References

• Original: J:80618 Mo FE, et al., CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity. Mol Cell Biol. 2002 Dec;22(24):8709-20
• All: 5 reference(s)