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Targeted Allele Detail
Symbol: Fgf8tm1.3Mrt
Name: fibroblast growth factor 8; targeted mutation 1.3, Gail R Martin
MGI ID: MGI:2150347
Synonyms: Fgf8clc, Fgf8fl, Fgf8flox
Gene: Fgf8  Location: Chr19:45725237-45731354 bp, - strand  Genetic Position: Chr19, 38.75 cM, cytoband C3-D
Alliance: Fgf8tm1.3Mrt page
Germline Transmission:  Earliest citation of germline transmission: J:45909
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThis allele is a derivative of Fgf8tm1.1Mrt in which mice carrying this allele were mated to beta-actin Flp mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which the neomycin resistance cassette was deleted, and exons 2 and 3 remained flanked by loxP sites. (J:45909)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 54 assay results
In Structures Affected by this Mutation: 43 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf8 Mutation:  18 strains or lines available
One of three alleles produced using a targeting construct capable of inducing different allelic variants when mated to mice that express cre, flp, or both. Referred to in the literature as Fgf8flox, Flp mediated recombinase reverts the hypomorphic Fgf8neo allele to wild-type (J:45909).
Original:  J:45909 Meyers EN, et al., An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet. 1998 Feb;18(2):136-41
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory