Phenotypes Associated with This Genotype

Genotype
MGI:3797716

• Allelic Composition: Myocd^tm1Msp/Myocd^tm1Msp; Tg(Pax3-cre)1Joe/0
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:131288 )

• die before P3

cardiovascular system

patent ductus arteriosus ( J:131288 )

• all mutants at P2 exhibit patent ductus arteriosus

• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus

• however, patterning of the cardiac outflow tract and great arteries is normal

cellular

patent ductus arteriosus ( J:131288 )

• all mutants at P2 exhibit patent ductus arteriosus

• E16.5 mutants exhibit diminished expression of smooth muscle cell contractile proteins in the ductus arteriosus

• however, patterning of the cardiac outflow tract and great arteries is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
patent ductus arteriosus		DOID:13832	OMIM:607411	J:131288