Rxra^tm1Rev
Targeted Allele Detail

Summary

• Symbol: Rxra^tm1Rev
• Name: retinoid X receptor alpha; targeted mutation 1, Ronald M Evans
• MGI ID: MGI:1857672
• Synonyms: RXRalpha-
• Gene: Rxra Location: Chr2:27566452-27652969 bp, + strand Genetic Position: Chr2, 19.38 cM
• Alliance: Rxra^tm1Rev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18047
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 3 and intron 3 was replaced with a neomycin resistance cassette. RT-PCR analysis on RNA derived from E13.5 embryos indicated that no normal transcript was produced from this allele in homozygous embryos. (J:18047)

Disease models

Expression

In Mice Carrying this Mutation:	144 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rxra Mutation: 30 strains or lines available

References

• Original: J:18047 Sucov HM, et al., RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 1994 May 1;8(9):1007-18
• All: 23 reference(s)