Phenotypes Associated with This Genotype

Genotype
MGI:5427936

• Allelic Composition: Gata4^tm1Grg/Gata4⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Atrial septal defects and semilunar valve stenosis in Gata4^tm1Grg/Gata4⁺ mice

cardiovascular system

aorta stenosis ( J:185124 )

• in 4 of 12 mutants

thin ventricle myocardium compact layer ( J:185124 )

abnormal heart atrium morphology ( J:185124 )

• thin

atrial septal defect ( J:185124 )

patent cardiac foramen ovale ( J:185124 )

• increase in the frequency of mice with intermittent shunting of blood between the atria

thick aortic valve cusps ( J:185124 )

• thickened aortic valve leaflets

thick pulmonary valve cusps ( J:185124 )

• thickened pulmonary valve leaflets

pulmonary valve stenosis ( J:185124 )

• in 2 of 12 mutants

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:185124 )

decreased fetal cardiomyocyte proliferation ( J:185124 )

• at E11.5 and E13.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrial heart septal defect 2		DOID:0110107	OMIM:607941	J:185124