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Phenotypes Associated with This Genotype
Genotype
MGI:3043036
Allelic
Composition
Cfc1tm1Cbm/Cfc1tm1Cbm
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfc1tm1Cbm mutation (0 available); any Cfc1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygous mutant mice died during the first few days after birth

cardiovascular system
• 82% of mutant mice exhibited malpositioning of heart outflow tracts
• in wild-type mice, the aorta is located dorsal and to the left of the pulmonary artery; in contrast, the mutant aorta connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery
• in wild-type mice, the pulmonary artery is always connected to the right ventricle; in mutant mice, the pulmonary artery connected to either the left or the right ventricle
• one out of seven mutant mice displayed double outlet right ventricle
• the pulmonary artery is connected to either the left or the right ventricle
• the aorta is connected to the right ventricle and emerged from the heart in a ventral position and to the right of the pulmonary artery
• in mutant mice, the apex of the heart pointed to the right (30%) or left (70%) side of the body; in wild-type mice, the apex of the heart pointed towards the left side of the body
• the position of the heart was independent of the position of the stomach; however, no looping abnormalities were observed at E8.5
• mutant mice displayed a common atrial chamber, as opposed to a left and a right atrium

digestive/alimentary system
• the stomach of mutant mice was located on either the left side (45%) or the right side (55%); in wild-type mice, the stomach is located on the left

growth/size/body
• the stomach of mutant mice was located on either the left side (45%) or the right side (55%); in wild-type mice, the stomach is located on the left
• in contrast to wild-type, both the right and left lungs of mutant mice had four lobes
• histological analysis confirmed loss of asymmetrical bronchi and branching patterns
• notably, mutant lungs diplayed no major tissue abnormalities

hematopoietic system
• the mutant spleen was small and abnormally shaped relative to wild-type

immune system
• the mutant spleen was small and abnormally shaped relative to wild-type

respiratory system
• in contrast to wild-type, both the right and left lungs of mutant mice had four lobes
• histological analysis confirmed loss of asymmetrical bronchi and branching patterns
• notably, mutant lungs diplayed no major tissue abnormalities


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory