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Allele Symbol Allele Name Allele ID |
Tg(Dbh-icre)1Gsc transgene insertion 1, Gunther Schutz MGI:4355551 |
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| Summary |
11 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of caspase 3-positive (apoptotic) cells is decreased compared to controls in the SCG at E17.5
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• number of caspase 3-positive (apoptotic) cells is decreased compared to controls in the SCG at E17.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice
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• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice
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• numbere of SCG neurons is increased compared to controls at E17.5
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• at E17.5 reduced numbers of apoptotic cells are observed compared to controls Creb1tm1Gsc null mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive birth and do not show reduced lifespans unlike lethality observed in Creb1-germline null mice
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| N |
• no major alterations in size of the superior cervical ganglia (SCG) or in morphology of noradrenergic neurons are observed at E17.5; SCG and stellate ganglion are properly shaped and placed compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased cell proliferation is observed at E11. and E12.5 (to 36 and 20% of controls respectively)
• levels of apoptotic cells is significantly increased at E11.5 and E13.5
• sympathetic ganglion size is reduced in area between E10.5 and 16.5 (3-fold decrease in area in contrast to 20-fold increase in size in controls)
• chromaffin cell numbers are decreased to <10% of those in controls at E13.5 (number of apoptotic chromaffin cells is strongly increased by E15.5); however, chromaffin cells in the adrenal glands are not affected
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• at E13.5, area of cells expressing the autonomic lineage marker Phox2b and noradrenergic and neuronal markers is reduced to <10% of that in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• sympathetic ganglia are significantly smaller and have fewer cells at E11.5, E14.5 and E18.5
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• expression analysis indicates a delay in noradrenergic differentiation in the sympathetic ganglia
• sympathetic ganglia are almost devoid of proliferating cells at E11.5 and have a dramatic reduction at E12.5 but by E14.5 the absolute number of BrdU-labeled cells is only slightly lower than in the wild-type
when corrected for the decrease in size of the sympathetic ganglia, proliferation is increased relative to wild-type at E14.5 and E16.5
• the number of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5r of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show mild reductions in size and cell number at E14.5 and are about two thirds the size of wild-type and have reduced cell numbers at E18.5
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• expression analysis indicates a transient delay in noradrenergic differentiation in the sympathetic ganglia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Meibomian glands lack sympathetic innervation
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• unable to fully open their eyes
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• have only a small rudiment of the stellate ganglion
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• small rudiment
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• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation
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• musculus tarsalis of the eyelid lacks sympathetic innervation
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• Meibomian glands lack sympathetic innervation
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• Meibomian glands lack sympathetic innervation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 of 16 mice develop abdominal tumors at 36-56 days of age
• tumors originate from the adrenals and/or the ganglion celiacum and some mice have thoracal or superior cervical ganglion tumors
• tumors consist almost entirely of small, round blue cells, similar to human neuroblastomas and express markers of neuroblastoma
• mice treated with JQ1, a compound that downregulates expression of N-myc and suppresses N-myc-driven transcription show increased cell death and reduced proliferation of tumors
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• 4 of 16 mice develop abdominal tumors at 36-56 days of age
• tumors originate from the adrenals and/or the ganglion celiacum and some mice have thoracal or superior cervical ganglion tumors
• tumors consist almost entirely of small, round blue cells, similar to human neuroblastomas and express markers of neuroblastoma
• mice treated with JQ1, a compound that downregulates expression of N-myc and suppresses N-myc-driven transcription show increased cell death and reduced proliferation of tumors
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neuroblastoma | DOID:769 | J:241988 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop abdominal tumors with an incidence of 76%
• tumor onset occurs between 26-337 days of age, with a mean age of 79.6 days
• tumors arise from the superior cervical ganglion, the adrenals, or the celiac ganglion
• histology indicates small round cell tumor with cells harboring neurosecretory vesicles and express markers indicative of neuroblastoma
• neuroblastomas are characterized by genomic aberrations syntenic to human neuroblastomas
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• hyperplastic cells are present in the adrenal medulla of some adrenal glands in 0-day old pups and most 14 and 28 day old mice
• at 28 days of age, the adrenal medulla has an atypical, nodal tissue architecture
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• mice develop abdominal tumors with an incidence of 76%
• tumor onset occurs between 26-337 days of age, with a mean age of 79.6 days
• tumors arise from the superior cervical ganglion, the adrenals, or the celiac ganglion
• histology indicates small round cell tumor with cells harboring neurosecretory vesicles and express markers indicative of neuroblastoma
• neuroblastomas are characterized by genomic aberrations syntenic to human neuroblastomas
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neuroblastoma | DOID:769 | J:222527 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice develop neuroblastomas within 48 days of age
• tumor incidence is higher and time to tumor formation is shorter than in mice expressing only Tg(Th-MYCN)41Waw
• tumors show a reduction in the number of genomic aberrations compared to tumors in mice expressing only Tg(Th-MYCN)41Waw or Tg(CAG-Alk*F1174L,-luc)60Jhsc
• mice bearing tumors treated with TAE-684, an ALK inhibitor, show some regression of tumors
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• all mice develop neuroblastomas within 48 days of age
• tumor incidence is higher and time to tumor formation is shorter than in mice expressing only Tg(Th-MYCN)41Waw
• tumors show a reduction in the number of genomic aberrations compared to tumors in mice expressing only Tg(Th-MYCN)41Waw or Tg(CAG-Alk*F1174L,-luc)60Jhsc
• mice bearing tumors treated with TAE-684, an ALK inhibitor, show some regression of tumors
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neuroblastoma | DOID:769 | J:186696 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• extensive liver metastases is seen in some mice
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• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas
• tumors form in the neck or abdomen
• the retroperitoneal tumors originate from the adrenal gland
• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil
• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas
• mice bearing tumors treated with TAE-684, an ALK inhibitor, show tumor regression
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• some adrenals appear hypertrophic in mice that do not develop tumors
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• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas
• tumors form in the neck or abdomen
• the retroperitoneal tumors originate from the adrenal gland
• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil
• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas
• mice bearing tumors treated with TAE-684, an ALK inhibitor, show tumor regression
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neuroblastoma | DOID:769 | J:186696 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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