Crem^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Crem^tm1Gsc
• Name: cAMP responsive element modulator; targeted mutation 1, Gunther Schutz
• MGI ID: MGI:2181391
• Synonyms: CREM-, CREM^lacZ
• Gene: Crem Location: Chr18:3266048-3337748 bp, - strand Genetic Position: Chr18, 2.14 cM, cytoband A
• Alliance: Crem^tm1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31889
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ and neomycin resistance cassette was inserted in frame into the sequences encoding the DNA binding domains. RNAase protection assays demonstrated that no normal transcript was expressed from this allele. A beta-galactosidase fusion protein is expressed from this allele under the control of the endogenous promoter. (J:31889)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crem Mutation: 38 strains or lines available

References

• Original: J:31889 Blendy JA, et al., Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature. 1996 Mar 14;380(6570):162-5
• All: 27 reference(s)