Analysis Tools
integument
| N |
• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced adipocyte volume
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• ratio of epididymal fat pad weight to body weight is reduced
• adipocyte number is not decreased, however, adipocyte size and lipid content is reduced
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• numbers of inflammatory adipose tissue macrophages (M1) are decreased, although total number is similar to control
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• numbers of non-inflammatory adipose tissue macrophage (M2) are increased, although total number is similar to controls
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• reduced HOMA-IR
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• decreased cholesterol level in white adipose tissue and heart
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• reduced plasma total cholesterol
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• increased cholesterol level in skeletal muscle
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• decreased triglyceride level in white adipose tissue
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• reduced plasma triglyceride at 12-13 weeks, but not 8 weeks
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• numbers of inflammatory adipose tissue macrophages (M1) are decreased, although total number is similar to control
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• numbers of non-inflammatory adipose tissue macrophage (M2) are increased, although total number is similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• response to rosiglitazone is similar to controls
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• on a high fat diet in a thermoneutral environment
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• practically indistinguishable from white adipocytes due to large accumulation of triglycerides in mice on a high fat diet in a thermoneutral environment
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• on a high fat diet in a thermoneutral environment
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• on a high fat diet in a thermoneutral environment
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• on a high fat diet in a thermoneutral environment
• on a regular chow diet in a thermoneutral environment weigh slightly but not significantly less than littermate controls
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• slight reduction when on a high fat diet in a thermoneutral environment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• weight of organ in mice fed a chow diet is increased by 40% compared to controls
• weight of organ in mice fed a high fat diet is increased by 40% compared to controls
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• weight of organ in mice fed a chow diet is increased by 41% compared to controls
• weight of organ in mice fed a high fat diet is increased by 129% compared to controls
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• mice on a high fat diet significantly increase their lean body mass compared to diet-matched controls
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• body length of mice on a high fat diet is significantly longer than controls
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• starting at 8 weeks of age, mice gain weight on a chow diet at a slightly higher rate than controls so that they are 4% heavier at 18 weeks of age
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• weight of organ in mice fed a chow diet is increased by 28% compared to controls
• weight of organ in mice fed a high fat diet is increased by 47% compared to controls
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• weight of liver in mice fed a high fat diet is increased by 75% compared to controls
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• weight of organ in mice fed a chow diet is increased by 38% compared to controls
• weight of organ in mice fed a high fat diet is increased by 62% compared to controls
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• insulin levels are significantly increased in fasted or fed mice, on either a chow or high-fat diet
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• IGF-1 serum levels are significantly increased on either a chow (21%) or a high fat diet (58%)
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• cholesterol levels are increased by almost 70% in mice fed a chow diet
• cholesterol levels are similar to controls when fed a high fat diet
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• mice are glucose tolerant on a chow diet despite being hyperinsulinemic
• mice have improved glucose tolerance on a high fat diet relative to controls
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• mice are slightly insulin resistance
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• adiponectin levels are decreased about 30% on either a chow or high fat diet
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• epididymal fat pad is increased by 30% on a high fat diet compared to diet-matched controls
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• pancreatic islet cells are at least 2-fold larger than controls with beta cells weighing twice as much as controls
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• weight of organ in mice fed a chow diet is increased by 41% compared to controls
• weight of organ in mice fed a high fat diet is increased by 129% compared to controls
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• weight of organ in mice fed a chow diet is increased by 40% compared to controls
• weight of organ in mice fed a high fat diet is increased by 40% compared to controls
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• weight of organ in mice fed a chow diet is increased by 38% compared to controls
• weight of organ in mice fed a high fat diet is increased by 62% compared to controls
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• weight of organ in mice fed a chow diet is increased by 38% compared to controls
• weight of organ in mice fed a high fat diet is increased by 62% compared to controls
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• weight of liver in mice fed a high fat diet is increased by 75% compared to controls
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• mice fed a high fat diet have more advanced steatosis than diet-matched controls
• the liver is larger and contains enlarged lipid droplets
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• weight of organ in mice fed a chow diet is increased by 28% compared to controls
• weight of organ in mice fed a high fat diet is increased by 47% compared to controls
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• there is a 15% increase in bone mineral content compared to controls
• bone density is normal indicating the skeleton is larger than controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males develop progressive lipodystrophy
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• increase in fed plasma insulin levels
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N |
• males exhibit normal mating behavior and sire offspring at normal frequencies, indicating normal fertility, show normal serum FSH, LH, testosterone and estradiol levels, and exhibit normal sperm
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| male infertility | DOID:12336 | J:211072 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in glucose infusion rate and whole-body and brown adipose tissue glucose uptake or reduction in endogenous glucose production observed in FGF-treated control mice
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• mice fed standard chow or a high fat diet and treated with FGF21 exhibit improved insulin sensitivity compared with control mice
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• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in brown adipose tissue glucose uptake observed in FGF-treated control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Severe growth retardation in Eif3mtm1Nju/Eif3mtm1Nju Tg(Fabp4-cre)1Rev/0 embryos at E9.5
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• severe at E9.5, but not as severe as in Eif3mtm1Nju/Eif3mtm1Nju Tg(Fabp4-cre)1Rev mice
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• severe at E9.5, but not as severe as in Eif3mtm1Nju/Eif3mtm1Nju Tg(Fabp4-cre)1Rev mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in white adipose tissue
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• in cold exposed mice due to decreased fatty acid oxidation
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• during cold exposure
• after adrenergic stimuli with isoproterenol or CL-316243
• however, glucose levels are normal after fasting
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• in response to CL-316243 due to reduced glycerol release by brown adipocytes
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• after adrenergic stimuli
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• in white adipose tissue when fed a low-fat diet with different fatty acid species
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• after cold exposure or CL-316243 treatment
• however, fasting does not abnormally increase fatty acid levels
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• with increased diacylglycerol level in white adipose tissue when fed a low-fat diet
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• after cold exposure
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• when fed a low-fat diet
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• when fed a 10% fat diet
• however, mice fed a high-fat diet exhibit normal weight gain and adipocity
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• when fed a low-fat diet
• however, mice fed a high-fat diet exhibit lipid levels
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• when fed a 10% fat diet or chow
• however, adipocyte size is normal
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• when fed a 10% fat diet
• however, mice fed a high-fat diet exhibit normal weight gain and adipocity
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• in white adipose tissue
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1.8-fold in mice fed a high-fat diet
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• 2-fold increase in mice fed a high-fat diet
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• 2-fold in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
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• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
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• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
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• in mice fed a high-fat diet
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| N |
• mice fed a high-fat diet exhibit normal glucose sensitivity as similarly treated wild-type mice
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• in mice fed a high-fat diet despite normal food intake
• however, mice fed standard chow exhibit normal weight
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• cold-exposed mice fed a high-fat diet exhibit lower body temperatures compared with wild-type mice
• however, body temperature when housed at 25 degrees Celsius is normal
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• in mice fed a high-fat diet during the light and dark phase
• however, oxygen consumption normalized to lean body mass is normal
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• in the white adipose tissue of mice fed a high-fat diet
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• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet
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• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet
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• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
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| N |
• mice fed standard chow or a high-fat diet exhibit normal lean mass
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• in mice fed a high-fat diet despite normal food intake
• however, mice fed standard chow exhibit normal weight
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• in the white adipose tissue of mice fed a high-fat diet
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• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet
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• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet
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• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
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• 1.8-fold in mice fed a high-fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pale color
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• 4.9-fold
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• 1.4-fold after 20 weeks on a high fat diet
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• 2.0-fold after 20 weeks on a high fat diet
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• 1.9-fold after 20 weeks on a high fat diet
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• when fed standard chow
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• under basal and isoproterenol-stimulated conditions, glycerol release and fatty acid release are decreased compared to in wild-type cells
• turnover of triacylglyceride and de novo palmitate is decreased in brown and white adipose tissue compared to in wild-type mice
• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice
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• impaired glucose uptake in brown and white adipose tissue
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• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice
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• at 12 and 14 weeks when fed a high fat diet
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• in a fasted state with decreased triacylglyceride hydrolase activity
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• in response to the beta3-agonist CL316243, mice fail to exhibit an increase in oxygen consumption unlike similarly treated wild-type mice
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• in fasted mice under cold exposure
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• in the liver with lower diacylglyceride levels
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• 60% in brown adipose tissue under basal conditions
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• when fed standard chow
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• at 12 and 14 weeks when fed a high fat diet
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• impaired glucose uptake in brown and white adipose tissue
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• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no gross abnormalities in body weight or size of major organs
• diet has no affect on body size in mice raised at 30C
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| N |
• white adipose tissue weight is normal
• brown adipose tissue more normal in appearance when mice are raised at 30C
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• 50% increase in mass of interscapular brown adipose tissue in mice raised at 21C
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• histological appearance more like white adipose tissue in mice raised at 21C
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• large amounts of triglycerides accumulated in a single large vacuole in mice raised at 21C
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• large amounts of triglycerides accumulated in a single large vacuole in mice raised at 21C
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| N |
• food intake similar to controls
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• roziglitazone up regulation of mitochondrial gene expression fails
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• many TCA cycle genes are down regulated in white adipose tissue
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• many respiratory chain enzymes are down regulated in white adipose tissue
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• many oxidative phosphorylation pathway genes are down regulated
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| N |
• glucose tolerance responses are normal
• insulin sensitivity is comparable to controls
• glucose and insulin responses to rosiglitazone are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while males on a normal chow diet are not obese, they show reduced perigonadal fat weight but increased interscapular brown adipose tissue at 3 months age
• however, body fat composition is no longer different by 6 months of age
• on a high-fat diet, males gain equal weight compared with controls, however after 24 weeks, they have more visceral fat, with increases in omental and mesenteric fat pad weights
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• on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age
• however, white adipose tissue morphology in the perigonadal and subcutaneous depots are normal
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• on a normal chow diet, males have reduced perigonadal fat weight and proportion
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• after 24 weeks of a high-fat diet, males show an increase in mesenteric fat pad weight compared to controls
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• after 24 weeks of a high-fat diet, males show an increase in omental fat pad weight compared to controls
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• on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age
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• on a normal chow diet, males gain less weight than controls at 3 months of age
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• males are euglycemic at 3 months of age, however between 3 and 12 months of age, males are unable to sustain the normal increase in insulin secretory capacity, and they develop hyperglycemia
• after 24 weeks on a high-fat diet, mutants have a poorer secretory response and become more hyperglycemic than controls
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• males are euglycemic but hyperinsulinemic both in the fasted state and during glucose tolerance testing at 3 months of age
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• 3 month old males have elevated plasma triglyceride levels but normal liver triglycerides
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• males show age-related glucose intolerance
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• insulin resistance in 3 month old males on a normal diet, as indicated by hyperinsulinemia both in the fasted state and during glucose tolerance
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 2 diabetes mellitus | DOID:9352 |
OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 |
J:196857 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female mice produce fewer pups per litter and the time between litters is slightly longer than in control mice that do not express cre
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| N |
• despite reduced adiposity, mice exhibit normal lipolysis
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• when fed a high fat diet, mice initially gain more weight than control mice but cease gaining weight after 2 to 3 weeks and over all weight gain is 41% of starting weight compared to 85% in control mice
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• when fed a standard or high fat diet
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• when fed a standard diet
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• when fed a standard or high fat diet
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• when fed a high fat diet
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• when fed a standard or high fat diet, oxygen consumption in white adipose cells is increased compared to in control cells
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• when fed a high fat diet
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• when fed a standard or high fat diet
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• when fed a standard diet, liver triglyceride levels are lower than in control mice
• however, mice fed a high fat diet exhibit normal liver steatosis and liver triglyceride levels
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• when fed a standard or high fat diet
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• when fed a standard or high fat diet
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• when fed a high fat diet
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• when fed a standard diet and more pronounced when fed a high fat diet
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• when fed a standard or high fat diet, mice are leaner than controls
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• when fed a standard diet, mice weight 18% less than control mice that do not express cre
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• when fed a high fat diet, mice initially gain more weight than control mice but cease gaining weight after 2 to 3 weeks and over all weight gain is 41% of starting weight compared to 85% in control mice
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• when fed a standard diet, mice are less active on a running wheel compared to control mice
• however, mice exhibit normal food intake
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| N |
• despite reduced adiposity, mice exhibit normal lipid absorption
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• when fed a standard diet, liver triglyceride levels are lower than in control mice
• however, mice fed a high fat diet exhibit normal liver steatosis and liver triglyceride levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cell loss greater than 80%
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• vacuole form sometimes like white adipose cells rather than typical brown fat cells
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• brown adipose tissue mass reduced more than 70% by 6 months of age
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• cell numbers reduced more than 95%
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• cells are larger and variable in size
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• more than 50% of white adipocytes are highly hypertrophic
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• diminution of interscapular fat pads detectable by 4-6 weeks
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• weight gain on a high fat diet is decreased
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• hepatomegaly eventually develops as well
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• insulin levels are increased
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• insulin became less efficient at suppressing glucose production
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• hepatomegaly eventually develops as well
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• livers were beginning to be steatotic at 6 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Reduced adiposity and unilocular lipid droplets in Fitm2tm1.1Dls/Fitm2tm1.1Dls Tg(Fabp4-cre)1Rev/? Lepob/Lepob mice
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• reduced body weight at 10 weeks relative to homozygous Lepob
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• at 10 weeks relative to homozygous Lepob
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• reduced epididymal white adipose tissue at 10 weeks relative to homozygous Lepob
• increased macrophage infiltration
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• at 10 weeks relative to homozygous Lepob
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Reduced amounts of subcutaneous white adipose tissue and epididmyal white adipose tissue in Fitm2tm1.1Dls/Fitm2tm1.1Dls Tg(Fabp4-cre)1Rev/? mice
| N |
• no change in body weight gain over time
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• weight gain after 10-12 weeks on a high fat diet
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• livers weigh 25% more than in controls at 24 weeks of age
• increased liver weights after 12 weeks on a high fat diet
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| N |
• normal food intake
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| N |
• normal plasma leptin levels
• normal glucose and insulin tolerance
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• after 12 weeks on a high fat diet
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• hyperinsulinemia at 24 weeks of age
• also after 12 weeks on a high fat diet
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• insulin intolerance at 24 weeks of age
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• higher basal and stimulated fatty acid release relative to controls after 12 weeks on a high fat diet
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• decreased white adipose tissue at 24 weeks of age
• decreased white adipose tissue after 12 weeks on a high fat diet
• macrophage infiltration of epididymal white adipose tissue
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• heterogeneity in adipocyte size after 12 weeks on a high fat diet
• lipid droplets significantly larger 4 days after adipocyte differentiation
• fewer lipid droplets than in controls
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• massive accumulation of macrophage after 12 weeks on a high fat diet
• indicative of increased adipocyte death
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• livers weigh 25% more than in controls at 24 weeks of age
• increased liver weights after 12 weeks on a high fat diet
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• after 12 weeks on a high fat diet
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• after 12 weeks on a high fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced by more than 65% compared to controls
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• difference in body weight is entirely due to the decrease in fat mass
• due to a macroscopically obvious decrease in the interscapular and epididymal fat pads
• increase in fat mass loss when fasted for 24 h
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• dramatic decrease in uptake of lipids by adipocytes
• decrease is more dramatic in brown adipose tissue compared to white adipose tissue
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• when placed on a high fat diet
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• increase in fat mass loss when fasted for 24 h
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| N |
• no difference in respiratory quotients is detected compared to controls
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• core temperature decreases faster when the ambient temperature is lowered compared to similarly exposed controls
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• consistent with the decrease in total body fat amount
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• at 22 degrees C core temperature is similar to controls but surface temperature is reduced
• the difference in surface temperature compared to controls becomes more pronounced at 4 degrees C
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• behavioral signs (shivering and trunk curl) indicate impaired ability to maintain body temperature
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• on normal chow and high fat diets
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• when placed on a high fat diet
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• markedly lower fasting glucose levels
• fasting glucose levels do not increase even after 16 weeks on a high fat diet
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• markedly lower fasting insulin levels
• fasting insulin levels do not increase even after 16 weeks on a high fat diet
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• results indicate that skeletal muscle is responsible for the elevated plasma glucose clearance
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• postprandial lipid clearance from the circulation in response to a bolus fat load is markedly delayed
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• markedly lower fasting non-esterified fatty acids levels
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• despite weighing less, mice consume more food compared to controls
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• body surface reduction by coiling up that is visible at room temperature (22 degrees C) but becomes more pronounced at 4 degrees C
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• enhanced skeletal muscle glucose uptake consistent with the increased muscle activity is seen
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• enhanced skeletal muscle glucose uptake consistent with the increased muscle activity is seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when standard chow despite lean mass
• when fed a high-fat diet despite no increase in food intake
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• when fed standard chow or a high-fat diet
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• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice
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• in epididymal and inguinal white adipose tissues when fed standard chow or a high-fat diet
• however, cell number is normal
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• enlarged
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• when standard chow despite lean mass
• when fed a high-fat diet despite no increase in food intake
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• at 3 and 6 months
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• when fed a high-fat diet despite no increase in food intake
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• when fed a high-fat diet despite no increase in food intake
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• when fed a high-fat diet
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• when fed a high-fat diet
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• when fed a high-fat diet
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• when fed a high-fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• starting at 9 weeks of age, male mice weigh more than littermate controls
• by 20 weeks of age, male mice have gained 15% more weight than controls
• however, female growth curves remain normal
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• liver weight is increased in male mice on an absolute scale but not relative to total body weight
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• male mice have significant increases in brown adipose tissue as measured on an absolute scale and normalized to body weight
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• weight of fat in grams for male mice is increased compared to control male mice starting at 6 weeks of age
• by 16 weeks of age, the weight of adipose tissue in male mice is almost double that of male control mice
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• adipocytes in male mice have increased cell size
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• male mice have significant increases in gonadal fat pad weight as measured on an absolute scale and normalized to body weight
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• male mice have significant increases in inguinal fat pad weight as measured on an absolute scale and normalized to body weight
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• male mice have significant increases in retroperitoneal fat pad weight as measured on an absolute scale and normalized to body weight
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• male mice have increased percent body fat starting at 6 weeks of age
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• serum adiponectin levels are about 20% lower in fasted male mice compared to male controls
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• liver weight is increased in male mice on an absolute scale but not relative to total body weight
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hyper-locomotor activity is retained
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• reproductive fat pads weigh significantly less in both males and females
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• low serum leptin levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice fed a high fat diet
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• in mice fed a high fat diet
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• whether mice are fed standard chow or a high fat diet
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• whether mice are fed standard chow or a high fat diet
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• in mice fed a high fat diet, but not standard chow
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• increased in muscle whether mice are fed standard chow or a high fat diet
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• in mice fed a high fat diet
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• increased in muscle whether mice are fed standard chow or a high fat diet
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• at 14 weeks when fed standard chow
• in mice fed a high fat diet
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• in mice fed a high fat diet
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• in mice fed a high fat diet
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• crown-like structures indicating increased damage in mice fed a high fat diet
• impaired fasting-induced fat pad weight reduction
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• in mice fed a high fat diet, but not standard chow
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• whether mice are fed standard chow or a high fat diet
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• impaired release of NEFA and glycerol in abdominal white and brown adipose tissue explants in response to beta-adrenoceptor agonist treatment
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• at 14 weeks when fed standard chow
• in mice fed a high fat diet
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• in mice fed a high fat diet
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• in mice fed a high fat diet, but not standard chow
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• lipid deposition in the liver and skeletal muscle of mice fed normal chow is the same as in Lepob homozygotes
|
|
• in mice fed normal chow compared to in Lepob homozygotes
|
|
• in mice fed normal chow compared to in Lepob homozygotes
|
|
• in mice fed normal chow compared with Lepob homozygotes
|
|
• in mice fed normal chow compared to in Lepob homozygotes
|
|
• fewer small adipocytes in mice fed normal chow compared to in Lepob homozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• brown adipose tissue is normal
|
|
• subcutaneous white adipose tissue
|
|
• reduced white adipose tissue detected by MRI
• particularly perigonadal, mesenteric, and subcutaneous adipose tissue
|
|
• stromal vascular cell fractions from white adipose tissue cannot be stimulated to differentiate
|
| N |
• normal glucose tolerance and insulin sensitivity
|
|
• subcutaneous white adipose tissue
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no viable adults are obtained; mice are born at the expected Mendelian ratio, but none survive beyond 25 days of age
|
|
• more than 50% die before postnatal day 5 (P5); remaining animals display failure to thrive and a wasting phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no significant difference in glucose homeostasis compared to controls
|
|
• in males and females at 2 and 12 months of age compared to control littermates
|
|
• in males and females at 2 and 12 months of age compared to control littermates
|
| N |
• no significant difference in fat mass or adipocyte size compared to controls
|
| N |
• no significant difference in body weight compared to controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice fed a high fat diet exhibit normal development of obesity and obesity-associated parameters
|
|
• decreased differentiation of stromal vascular cell to adipocytes
|
|
• in the visceral retroperitoneal and subcutaneous adipose of mice fed a low fat diet
|
|
• in the visceral retroperitoneal and subcutaneous adipose of mice fed a low fat diet
|
| N |
• mice fed a high fat diet exhibit normal development of obesity and obesity-associated parameters
|
| N |
• mice fed a high fat diet exhibit normal development of obesity and obesity-associated parameters
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice fed a high-fat diet exhibit similar body weight accumulation and glucose and insulin tolerance as controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• do not show glucose intolerance at 12 weeks of age
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 2 months in male mice
• at 4 months in female mice
|
|
• in subcutaneous and perigonadal fat pads
|
|
|
• in female, but not male, mice
|
| N |
• mice exhibit normal glucose homeostasis
|
|
|
• in male, but not female, mice
|
|
|
• in female, but not male, mice
|
|
|
• in female, but not male, mice
|
|
• mice exhibit increased fluid mass
|
|
|
• slightly decreased in the serum of male, but not female, mice
|
|
• at 10 months in male mice
• at 5 to 10 months in female mice
|
|
• by 3 months in male mice
• by 5 months in female mice
|
|
|
• in female, but not male, mice
|
|
|
• in male, but not female, mice
|
|
|
• in female, but not male, mice
|
|
|
• in female, but not male, mice
|
|
|
• in female, but not male, mice
|
|
|
• in male, but not female, mice
|
|
|
• in female, but not male, mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Enhanced lipid deposition with increased lipid droplet sizes of brown adipose tissue in Sqstm1tm2.1Jmos/Sqstm1tm2.1Jmos Tg(Fabp4-cre)1Rev/0 mice
|
• at room temperature and during acute cold exposure
|
|
• in mice fed standard chow but not a high fat diet
|
|
• in mice fed standard chow or a high fat diet
|
|
• in mice fed standard chow
• however, fat mass is normal in mice fed a high fat diet
|
|
• impaired nonshivering thermogenesis above brown adipose tissue treated with the selective beta-3 adrenergic receptor agonist CL-316,243
|
|
• fewer and shorter cristae displaced to the periphery with varying degrees of disorientation in the mitochondria of brown adipose tissue
|
|
• in the mitochondria of brown adipose tissue
|
|
• decreased oxidative capacity in the mitochondria of brown adipose tissue
|
|
• in mice fed a high fat diet
• however, lean mass is normal in mice fed standard chow
|
|
• in mice fed standard chow or a high fat diet
|
|
• in mice fed standard chow or a high fat diet
|
| N |
• mice fed standard chow or a high fat diet exhibit normal food intake
|
|
• reduced locomotor activity (total and mean dark but not mean light)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• epididymal white and brown interscapular brown fat pads in 4 month-old animals are similar in mutants and controls
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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