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Targeted Allele Detail
Symbol: Acsl1tm1Rcol
Name: acyl-CoA synthetase long-chain family member 1; targeted mutation 1, Rosalind Coleman
MGI ID: MGI:4417846
Synonyms: Acsl1flox
Gene: Acsl1  Location: Chr8:46924074-46989088 bp, + strand  Genetic Position: Chr8, 26.36 cM, cytoband B2
Alliance: Acsl1tm1Rcol page
Germline Transmission:  Earliest citation of germline transmission: J:155714
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site and FRT flanked MC1-neo cassette were inserted 5' to exon 2 and an additional loxP site was placed immediately 3' of exon 2. The neomycin cassette was then excised by transient expression of Flpe recombinase. Cre expression in the liver of homozygous mice eliminates most mRNA for this gene. (J:155714)
Generation of Acsl1tm1Rcol allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acsl1 Mutation:  27 strains or lines available
Original:  J:155714 Li LO, et al., Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem. 2009 Oct 9;284(41):27816-26
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
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